A5052861733- Fungal Infections and Studies
- Cutaneous lymphoproliferative disorders research
- CAR-T cell therapy research
- Toxin Mechanisms and Immunotoxins
- T-cell and Retrovirus Studies
LEO Foundation
2023-2024
University of Copenhagen
2023-2024
Patients with Sézary syndrome (SS), a leukemic variant of cutaneous T-cell lymphoma (CTCL), are prone to Staphylococcus aureus infections and have poor prognosis due treatment resistance. Here, we report that S staphylococcal enterotoxins (SE) induce drug resistance in malignant T cells against therapeutics commonly used CTCL. Supernatant from patient-derived, SE-producing recombinant SE significantly inhibit cell death induced by histone deacetylase (HDAC) inhibitor romidepsin primary...
Staphylococcus aureus is suspected to fuel disease activity in cutaneous T-cell lymphomas. In this study, we investigate the effect of a recombinant, antibacterial protein, endolysin (XZ.700), on S. skin colonization and malignant activation. We show that strongly inhibits proliferation isolated from lymphoma significantly decreases bacterial cell counts dose-dependent manner. Likewise, ex vivo both healthy lesional by profoundly inhibited endolysin. Moreover, patient-derived induction IFNγ...
Cutaneous T-cell lymphoma (CTCL) is characterized by malignant T-cells proliferating in a unique tumor microenvironment (TME) dominated keratinocytes. Skin colonization and infection Staphylococcus aureus (S. aureus) common cause of morbidity suspected fueling disease activity. Here we show that expression HLA-DR, high-affinity receptors for Staphylococcal enterotoxins (SE), keratinocytes correlates with IFN-γ the TME. Importantly, induces SE-binding, SE-presentation to from Sézary syndrome...