Marion Wobser
A5043269673- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Nail Diseases and Treatments
- Fungal Infections and Studies
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Vascular Tumors and Angiosarcomas
- T-cell and Retrovirus Studies
- Genetic and rare skin diseases.
- Eosinophilic Disorders and Syndromes
- Tumors and Oncological Cases
- Antenna Design and Analysis
- Immunotherapy and Immune Responses
- Sarcoma Diagnosis and Treatment
- Dermatological and Skeletal Disorders
- Polyomavirus and related diseases
- Cancer and Skin Lesions
- Ocular Oncology and Treatments
- Toxin Mechanisms and Immunotoxins
- Full-Duplex Wireless Communications
- Skin and Cellular Biology Research
- Melanoma and MAPK Pathways
- Soft tissue tumor case studies
Universitätsklinikum Würzburg
2016-2025
Austrian Society of Dermatology and Venereology
2016-2025
Universitäts-Kinderklinik Würzburg
2023
Comprehensive Cancer Center Mainfranken
2014-2021
John Wiley & Sons (United States)
2021
John Wiley & Sons (United Kingdom)
2021
University of Würzburg
2010-2021
Oxfam
2021
Hudson Institute
2021
European Organisation for Research and Treatment of Cancer
2018
Survival in mycosis fungoides (MF) is varied and may be poor. The PROCLIPI (PROspective Cutaneous Lymphoma International Prognostic Index) study a web-based data collection system for early-stage MF with legal data-sharing agreements permitting international collaboration rare cancer complex pathology. Clinicopathological must 100% complete in-built intelligence the database ensures accurate staging.
Common birthmarks can be an indicator of underlying genetic disease but are often overlooked. Mongolian blue spots (dermal melanocytosis) usually localized and transient, they extensive, permanent, associated with extracutaneous abnormalities. Co-occurrence vascular defines a subtype phakomatosis pigmentovascularis, group syndromes neurovascular, ophthalmological, overgrowth, malignant complications. Here, we discover that extensive dermal melanocytosis pigmentovascularis activating...
The pocket protein (PP) family consists of the three members RB1, p107 and p130 all possessing tumor suppressive properties. Indeed, PPs jointly control G1/S transition mainly by inhibiting E2F transcription factors. Notably, several viral oncoproteins are capable binding PPs. Merkel cell polyomavirus (MCPyV) is considered as etiological factor for carcinoma (MCC) with expression Large T antigen (LT) harboring an intact PP domain being required proliferation most MCC cells. Therefore, we...
Mycosis fungoides (MF) and Sézary Syndrome (SS) are the most common cutaneous T-cell lymphomas. MF/SS is accompanied by considerable morbidity from pain, itching disfigurement.To identify factors associated with poorer health-related quality of life (HRQoL) in patients newly diagnosed MF/SS.Patients enrolled into Prospective Cutaneous Lymphoma International Prognostic Index (PROCLIPI; an international observational study MF/SS) had their HRQoL assessed using Skindex-29 questionnaire. scores...
Abstract The transcription factor NRF2 is the major mediator of oxidative stress responses and closely connected to therapy resistance in tumors harboring activating mutations pathway. In melanoma, such are rare, it unclear what extent melanomas rely on NRF2. Here we show that suppresses activity melanocyte lineage marker MITF thereby reducing expression pigmentation markers. Intriguingly, furthermore identified as key regulator immune-modulating genes, linking with induction cyclooxygenase...
Cutaneous lymphomas (CL) are categorized as extranodal non-Hodgkin lymphomas, constituting the second most common form in this group (MALT of stomach form). Their incidence is estimated at one new diagnosis per 100,000 inhabitants year Germany [1-3]. Primary CL, by definition, present skin first, and time after staging completed do not show any involvement other organs. Secondary on hand, cutaneous manifestations disseminated [4], primarily nodal or leukemias. CL comprise a large, clinically...
Patients with Sézary syndrome (SS), a leukemic variant of cutaneous T-cell lymphoma (CTCL), are prone to Staphylococcus aureus infections and have poor prognosis due treatment resistance. Here, we report that S staphylococcal enterotoxins (SE) induce drug resistance in malignant T cells against therapeutics commonly used CTCL. Supernatant from patient-derived, SE-producing recombinant SE significantly inhibit cell death induced by histone deacetylase (HDAC) inhibitor romidepsin primary...
The PROspective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) study is a prospective analysis of an international database. Here we examine front-line treatments and quality life (QoL) in patients with newly diagnosed mycosis fungoides (MF).
Abstract Targeted therapies for cutaneous T-cell lymphoma (CTCL) are limited and curative approaches lacking. Furthermore, relapses drug induced side effects major challenges in the therapeutic management of patients with CTCL, creating an urgent need new effective therapies. Pathologic constitutive NF-κB activity leads to apoptosis resistance CTCL cells and, thus, represents a promising target CTCL. In preclinical study we showed potential dimethyl fumarate (DMF) block specifically, kill...
Therapeutic vaccination directed to induce an anti-tumoral T-cell response is a field of extensive investigation in the treatment melanoma. However, many trials melanoma failed demonstrate correlation between vaccine-specific immune and therapy outcome. This has been mainly attributed escape by antigen loss, rendering us need new targets.This phase-II trial investigated peptide against survivin, oncogenic inhibitor-of-apoptosis protein crucial for survival tumor cells,...
Indolent cutaneous CD8+ lymphoid proliferation is a recently described rare entity among T-cell lymphomas that typically presents with solitary skin lesions at acral sites. Separation from otherwise aggressive bearing cytotoxic phenotype fundamental to avoid unnecessary harmful treatment. However, up now, no reliable discriminative marker has been identified.Motivated by these diagnostic quandaries, we have analyzed large series of archived formalin-fixed paraffin-embedded (FFPE) specimens...
Pleomorphic dermal sarcomas (PDS) are frequent UV-induced of the skin intermediate grade malignant potential. Despite fact that PDS have a noteworthy potential to recur (up 28%) as well metastasize 20%), there no specific clinical guidelines with respect follow-up these patients. Moreover, little is known about clinical, histological or molecular prognostic factors in PDS.The aim present study was identify risk predict relapse large multicentre sample cohort which could aid optimize...
The differential diagnosis of atypical dermal nonepidermotropic CD8+ lymphocytic infiltrates includes a heterogeneous spectrum lymphoproliferations with overlapping histological and phenotypic features, but divergent clinical manifestations prognoses. As these neoplasms are rare, more data on their clinicopathological presentation course needed.To assess the clinical, immunophenotypic features; outcomes of; differences between lymphoproliferations.Retrospective analysis series 46 patients...
Targeting epigenetic modifiers is effective in cutaneous T cell lymphoma (CTCL). However, there a need for further improvement of this therapeutic approach. Here, we compared the mode action romidepsin (FK228), an established class I histone deacetylase inhibitor, and domatinostat (4SC-202), novel inhibitor HDACs, which has been reported to also target lysine-specific demethylase 1A (LSD1). We performed MTS assays flow cytometric analyses propidium iodide or annexin V-stained cells assess...
Kutane Lymphome (cutaneous lymphomas; CL) gehören zur Gruppe der extranodalen Non-Hodgkin-Lymphome, innerhalb derer sie die zweithäufigste Form darstellen (Magen-MALT-Lymphome sind häufigste extranodale Form). Die Inzidenz wird auf eine Neuerkrankung pro Jahr und 100 000 Einwohner geschätzt [1-3]. Primäre CL manifestieren sich definitionsgemäß zunächst in Haut zeigen zum Zeitpunkt Diagnosestellung nach abgeschlossener Ausbreitungsdiagnostik (Staging) keine weitere Organbeteiligung, während...