A5083146096- Polyomavirus and related diseases
- Antenna Design and Analysis
- Thyroid Cancer Diagnosis and Treatment
- Full-Duplex Wireless Communications
- Plant Virus Research Studies
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Peptidase Inhibition and Analysis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Bacteriophages and microbial interactions
- Cancer and Skin Lesions
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Pituitary Gland Disorders and Treatments
- Protease and Inhibitor Mechanisms
- Head and Neck Anomalies
- Cancer Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Thyroid and Parathyroid Surgery
- Parathyroid Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Tumors and Oncological Cases
Université de Tours
2016-2025
Centre Val de Loire
2014-2025
Infectiologie Animale et Santé Publique
2017-2024
Centre Hospitalier Universitaire de Tours
2015-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2019-2024
Université de Poitiers
2023
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2021
Virologie et Pathologies Humaines
2021
Hôpital Dupuytren
2021
Patient-Centered Outcomes Research Institute
2020
Purpose A new human polyomavirus, Merkel cell polyomavirus (MCV), was identified in 2008 tumor tissue of patients with carcinoma (MCC), a relatively rare skin cancer. In this study, we investigated MCC and controls for the presence antibodies against MCV their association clinical characteristics. Patients Methods Antibodies were by enzyme-linked immunosorbent assay 68 82 using VP1 virus-like particles produced insect cells. Results detected all 85% controls. However, high antibody titers...
We report a prospective quantitative image analysis study of C cells in 57 normal autopsy thyroid glands, serially sectioned and wholly embedded paraffin; all slides were immunohistochemically stained for calcitonin. Computerized was performed on 47 cases to measure cell surface area parenchymatous after immunoperoxidase staining The method time-effective, with good reproducibility. mainly found the middle third each lobe. Important inter-individual variations observed; maximum section...
The genome of a new human polyomavirus, known as Merkel cell polyomavirus (MCV), has recently been reported to be integrated within the cellular DNA carcinoma (MCC), rare skin cancer. To investigate MCV seroprevalence in general population, we expressed three different VP1 insect cells using recombinant baculoviruses. Viruslike particles (VLPs) were obtained with only one genes. High-titer antibodies against VLPs detected mice immunized VLPs, and limited cross-reactivity was observed BK...
Background: Anaplastic thyroid carcinoma (ATC) is a rare tumor, with poorly defined oncogenic molecular mechanisms and limited therapeutic options contributing to its poor prognosis. The aims of this retrospective study were determine the frequency anaplastic lymphoma kinase (ALK) translocations identify mutational profile ATC including TERT promoter mutations. Methods Materials: One hundred forty-four cases collected from 10 centers that are part national French network for management...
The primary endpoint was to analyze the predictive factors of lymph node involvement (LN+).Indications for additional right hemicolectomy (RHC) with (LN) resection after appendectomy appendix neuroendocrine tumor (A-NET) remain controversial, especially tumors between 1 and 2 cm in size.National study including all patients nonmetastatic A-NET diagnosed January, 2010 France.In all, 403 were included. A-NETs were: within tip (67%), body (24%) or base (9%) appendix; size < (62%), (30%), >2...
Journal Article Prognostic value of antibodies to Merkel cell polyomavirus T antigens and VP1 protein in patients with carcinoma Get access M. Samimi, Samimi Université François Rabelais Tours FranceINRA UMR 1282 ISP 31 Avenue Monge 37200 FranceDermatology Department CHU de la République 37170 France Correspondence Mahtab Samimi. E‐mail: mahtab.samimi@univ-tours.fr Search for other works by this author on: Oxford Academic Google Scholar L. Molet, Molet Assistance Publique des Hôpitaux Paris...
Thyroid oncocytic adenomas are a class of tumors characterized by the presence abundant mitochondria. We performed differential display RT-PCR analysis on two and their paired controls. then carried out microarray using 460 selected, differentially expressed clones four other oncocytomas Thirty genes, 12 encoded mitochondrial DNA 18 nuclear-encoded, were overexpressed factor at least 2 in compared with Seven nuclear-encoded genes involved protein metabolism: DKFZP434I116, B3GTL, SNX19, RP42,...
Abstract We investigated whether Merkel cell carcinoma (MCC) patients in France carry polyomavirus (MCPyV) and then identified strain variations. All frozen MCC specimens 45% of formalin-fixed paraffin-embedded specimens, but none the non-MCC neuroendocrine carcinomas had MCPyV. Strains from United States were similar.
<b><i>Introduction:</i></b> High-grade lung neuroendocrine tumours with carcinoid morphology have been recently reported; they may represent the thoracic counterparts of grade 3 digestive tumours. We aimed to study their genetic landscape including analysis tumoral heterogeneity. <b><i>Methods:</i></b> Eleven patients high-grade (&#x3e;20% Ki-67 and/or &#x3e;10 mitoses) a were included. analysed copy number variations, somatic...
The cell adhesion protein CD56 has been identified as a potential therapeutic target in several solid tumors and hematological malignancies. Recently, we developed CD56-directed antibody-drug conjugate (ADC), called Adcitmer demonstrated its antitumor properties preclinical models of the rare aggressive skin cancer Merkel carcinoma (MCC). present study aims to further optimize overcome limitations observed with previously evaluated CD56-targeting ADCs, which were partially related toxic...
Oxyphilic tumors (oncocytomas or Hürthle cell tumors) form a rare subgroup of thyroid characterized by cells containing abundant mitochondria. The relationship between the mitochondrial proliferation and pathogenesis these is unknown. We have assessed expression ND2 ND5 (subunits nicotinamide adenine dinucleotide dehydrogenase complex) genes nuclear UCP2 (uncoupling protein 2) gene in 22 oxyphilic matched controls. consumption oxygen mitochondria from was determined polarography. ATP assays...
Oncocytomas are large cell tumors characterized by an abnormal proliferation of mitochondria. To investigate this phenomenon in thyroid oncocytomas, we determined gene expression profiles 87 samples using microarrays 6720 PCR products from cDNA clones. Samples included 29 oncocytomas and six papillary carcinomas, the remainder representing other pathologies or mitochondria-rich tumor samples, normal two lines. Hierarchical clustering supervised analysis identified specific oncocytic clusters...
Gonadotropin-secreting pituitary adenomas carry a high risk of local recurrence or progression (R/P) remnant tumor after first surgery. The clinical characteristics and the long-term outcome these silent adenomas, which show no signs endocrine hyperfunction, differ from those other types adenomas. However, to date, study has focused specifically on gonadotropic adenomas.To identify prognostic factors R/P remnants, we studied postoperative 32 defined immunohistochemical staining, according...
Abstract Background: A relatively unexplored area for biomarker identification is alternative splice variants. We undertook this study to evaluate the usefulness of mRNA isoforms encoded by KLK8 (kallikrein-related peptidase 8) gene as prognostic markers lung cancer. Methods: Real-time reverse-transcription PCR was used analyze mRNAs (particularly 2 variants, KLK8-T3 and KLK8-T4) in 60 non–small-cell cancer (NSCLC) tumors paired unaffected tissues. The ratios these those KLK5, KLK6, KLK7,...
MicroRNA expression signatures can promote personalised care for non-small cell lung cancer (NSCLC) patients. Our aim was to evaluate the previously unexplored prognostic potential of miR-197, a key oncogenic molecule NSCLC. Total RNA isolation (n=124 NSCLC and n=21 tumour-adjacent normal tissues), performed using QIAsymphony SP workstation. The quantity quality were assessed by spectrophotometric analysis an Agilent 2100 bioanalyzer. Polyadenylation reverse transcription subsequently...
Emilie Dalloneau1,2, Nadine Baroukh3, Konstantinos Mavridis4, Agnès Maillet1,2, Fabien Gueugnon1,2, Yves Courty1,2, Petit1,2, Thomas Kryza5, Maguy Del Rio6, Serge Guyetant1,2, Diana Carolina Cadena Castaneda3, Christine Dhommée3, Christophe Arnoult3, Andreas Scorilas4, Valérie Gouilleux-Gruart3,7,*, Nathalie Heuzé-Vourc'h1,2,* 1Université François Rabelais, UMR 1100, Tours, France 2INSERM, Centre d'Etude des Pathologies Respiratoires, 3Université Rabelais de CNRS, GICC 7292, 4Department of...
<b><i>Introduction:</i></b> Many changes have recently occurred in the practice of neuroendocrine tumour (NET) pathology. We therefore aimed to evaluate how pathologists adapted their daily most recent international guidelines for diagnostic and prognostic evaluation. <b><i>Procedures:</i></b> A 12-month prospective study (PRONET) was carried out among French between August 2010 July 2011. Data were collected using an anonymous electronic case...
<b><i>Background/Aims:</i></b> Merkel cell carcinoma (MCC) is a rare high-grade neuroendocrine tumour of the skin. It has been speculated that MCCs express somatostatin receptors (SSTRs), but this never assessed in large series MCCs. The main aim study was to assess expression SSTR2A and SSTR5 MCC tumours. secondary aims were whether SSTR associated with Ki67 proliferative index, polyomavirus (MCPyV) status, clinical characteristics outcome....
Merkel cell carcinoma (MCC), an aggressive neuroendocrine of the skin, is to date only human cancer known be frequently caused by a polyomavirus. However, it matter debate which cells are targeted polyomavirus (MCPyV) give rise phenotypically multifaceted MCC cells. To assess lineage origin MCPyV-positive MCC, genetic analysis very rare tumor combining benign trichoblastoma and was conducted massive parallel sequencing. Although MCPyV found integrated in part, six somatic mutations were...
Cigarette smoking has marked effects on lung tissue, including induction of oxidative stress, inflammatory cell recruitment, and a protease/antiprotease imbalance. These contribute to tissue remodeling destruction resulting in loss function chronic obstructive pulmonary disease (COPD) patients. Cathepsin S (CatS) is cysteine protease that involved the remodeling/degradation connective basement membrane. Aberrant expression or activity CatS been implicated variety diseases, arthritis, cancer,...