A5053986460- Cutaneous lymphoproliferative disorders research
- Autoimmune Bullous Skin Diseases
- Fungal Infections and Studies
- Autoimmune and Inflammatory Disorders
- Nonmelanoma Skin Cancer Studies
- Lymphoma Diagnosis and Treatment
- Urticaria and Related Conditions
- Urologic and reproductive health conditions
- Cancer Diagnosis and Treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer and Skin Lesions
- Prostate Cancer Treatment and Research
- Dermatology and Skin Diseases
- Eosinophilic Disorders and Syndromes
- Hidradenitis Suppurativa and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Genital Health and Disease
- Chronic Lymphocytic Leukemia Research
- Prostate Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Cutaneous Melanoma Detection and Management
- Nail Diseases and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bladder and Urothelial Cancer Treatments
- Medicine and Dermatology Studies History
Université de Reims Champagne-Ardenne
2016-2025
Centre Hospitalier Universitaire de Reims
2016-2025
Hôpital Maison Blanche
2011-2025
Inserm
2019-2025
Pathologies Pulmonaires et Plasticité Cellulaire
2020-2024
Hôpital Robert-Debré
2009-2022
Oxfam
2020
John Wiley & Sons (United States)
2020
John Wiley & Sons (United Kingdom)
2020
Hudson Institute
2020
In 1999, we reported seven cases of an unusual hematologic malignancy with primary cutaneous presentation that appeared as a distinct clinicopathologic entity characterized by medium-sized tumor cells peculiar CD3− CD4+ CD56+ CD43+ HLA-DR+ cell surface phenotype. Because the origin was not clear and they exhibited nonlineage-specific phenotype, hypothesized such tumors likely originated from hematologic–myeloid precursor were tentatively assigned designation "agranular hematodermic...
Blastic natural killer (NK) cell lymphoma (also termed CD4+CD56+ hematodermic neoplasm) is a recently described entity, with the first case reported in 1994. It was suggested initially that disease originates from NK cells. Since 1994, single cases and few small series have been published. In this review, data literature of 30 French Dutch study groups on cutaneous lymphomas are discussed. The major clinical, histopathologic, phenotypic aspects diagnostic criteria suggesting plasmacytoid...
The authors report 4 cases of cutaneous lymphoproliferation unusual by their histology and clinical presentation. Each presented with a history slow growing nodule on the ear. Despite indolent evolution, suggested high-grade lymphoma. All lesions consisted dense, diffuse proliferation monomorphous medium-sized T cells throughout dermis subcutis. There was no epidermotropism grenz zone clearly present in each case. tumor displayed irregular blastlike nuclei, small nucleoli clear chromatin had...
FTIR spectral imaging was applied on formalin-fixed paraffin-embedded biopsies from colon and skin cancerous lesions. These samples were deposited onto different substrates (zinc selenide calcium fluoride respectively) embedded using two types of paraffin. Formalin fixation followed by paraffin embedding is the gold standard in tissue storage. It can preserve molecular structures it compatible with immunohistochemistry. However, absorption bands are significant mid-infrared region mask some...
Background Primary cutaneous lymphomas (PCLs) are a heterogeneous group of T-cell (CTCL) and B-cell (CBCL) malignancies. Little is known about their epidemiology at initial presentation in Europe potential changes over time. Objectives The aim this retrospective study was to analyse the frequency PCLs French Cutaneous Lymphoma Registry (GFELC) describe demography patients. Methods Patients with centrally validated diagnosis primary PCL, diagnosed between 2005 2019, were included. Results...
Abstract We investigated whether Merkel cell carcinoma (MCC) patients in France carry polyomavirus (MCPyV) and then identified strain variations. All frozen MCC specimens 45% of formalin-fixed paraffin-embedded specimens, but none the non-MCC neuroendocrine carcinomas had MCPyV. Strains from United States were similar.
Abstract Hidradenitis suppurativa/acne inversa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle, associated with considerable tissue remodelling. Although abnormal cytokine expression was detected both in perilesional and uninvolved skin, up to now there no model allowing better understanding implicit inflammatory mechanisms HS. The aim this study investigate response HS by mean an ex vivo culture. To that purpose, nine biopsy specimens from patients...
ABSTRACT Thymic stromal lymphopoietin (TSLP) is an alarmin cytokine activated by allergens, pathogens, and air pollutants. Recent studies suggest TSLP dysregulation in chronic inflammatory diseases. It was highlighted as a key player the context of asthma‐associated mucosal immunity. This study investigated production localization its receptors airway epithelial cells related response obstructive pulmonary disease (COPD) non‐COPD patients. transcripts proteins were detected but not abundant...
Hirschsprung disease is a congenital anomaly characterised by an absence of innervation in the colon. The current diagnosis, which involves identifying non-functional part colon through histological examination, unsatisfactory. objective our study was to assess potential infrared spectroscopy as label-free method distinguish between functional and parts Tissue samples from FFPE sections patients, taken both regions, were analysed mid-infrared imaging. Colour-coded spectral images,...
Osimertinib, a third-generation tyrosine kinase inhibitor that targets epidermal growth factor receptor (EGFR), specifically inhibits both EGFR inhibitor-sensitive mutations and T790M resistance mutations. Despite initial positive responses to inhibitors, nearly all patients eventually experience disease progression. Mechanisms of are classically divided into EGFR-dependent EGFR-independent mechanisms, such as the activation alternative pathways histological changes. We report case...
Penile squamous cell carcinoma (SCC) may occur on pre-existing lesions of lichen sclerosus (LS). However, the prevalence histological changes LS in penile SCC is not well established. Moreover, mucosal oncogenic human papillomaviruses (HPVs) are sometimes detected SCC, but have been systematically sought LS-associated SCC.To establish and HPV a series patients with SCC.Consecutive cases histologically proven from single university hospital over 14-year period were retrospectively selected...
Background DNA extracellular traps (ETs), released by neutrophils (NETs) or eosinophils (EETs), play a pathogenic role in several autoimmune disorders. However, to date, NETs have never been investigated bullous pemphigoid (BP) with respect clinical and immunological activities, both at baseline time of relapse which characterized specific IL-17 IL-23 patterns. Objective: We sought assess whether ETs were associated BP as well the relative contribution axis cytokines NET induction. Methods:...
Bullous Pemphigoid (BP) is a skin autoimmune blistering disease characterized by immune-mediated degradation of the dermo-epidermal junction and release large number inflammatory cytokines. Interleukin-1β (IL-1β) pleiotropic pro-inflammatory cytokine associated with inflammasome activation known to be pivotal in several auto-immune auto-inflammatory diseases. We sought clarify presence inflammasome-dependent IL-1β investigate its role BP. Skin biopsy specimens (n=13), serum (n=60), blister...
BACKGROUND Genital Bowen disease is known to have a strong association with human papillomavirus (HPV) type 16. On the other hand, previous studies of extragenital (EBD) that used different hybridization techniques produced discordant results in detection mucosal oncogenic HPV. METHODS Ninety-four samples EBD from 78 patients were investigated clinicopathologically. DNA extracted fixed and embedded tissues was analyzed for presence main HPV types 16, 18, 31, 33 using polymerase chain...
Melanoma is the more dangerous skin cancer, and metastatic melanoma still carries poor prognosis. Despite recent therapeutic advances, prolonged survival remains rare research required. Propolis extracts from many countries have attracted a great deal of attention for their biological properties. We here investigated ability an ethanolic extract Algerian propolis (EEP) to control tumour growth when given mice bearing B16F1melanoma either as preventive or treatment. EEP after occurrence...