A5044024585- Psoriasis: Treatment and Pathogenesis
- Cancer Immunotherapy and Biomarkers
- Dermatology and Skin Diseases
- Cutaneous Melanoma Detection and Management
- Polyomavirus and related diseases
- Cervical Cancer and HPV Research
- Cutaneous lymphoproliferative disorders research
- Autoimmune Bullous Skin Diseases
- CAR-T cell therapy research
- Urticaria and Related Conditions
- Nonmelanoma Skin Cancer Studies
- Melanoma and MAPK Pathways
- Skin Protection and Aging
- Immunotherapy and Immune Responses
- Colorectal Cancer Treatments and Studies
- Autoimmune and Inflammatory Disorders
- Genital Health and Disease
- Allergic Rhinitis and Sensitization
- Nail Diseases and Treatments
- Full-Duplex Wireless Communications
- Antenna Design and Analysis
- Contact Dermatitis and Allergies
- Colorectal and Anal Carcinomas
- Hidradenitis Suppurativa and Treatments
- Drug-Induced Adverse Reactions
Inserm
2015-2025
Université de franche-comté
2016-2025
Centre Hospitalier Universitaire de Besançon
2016-2025
Methodology and Quality of Life Unit in Oncology
2005-2025
Institut Pluridisciplinaire Hubert Curien
2024-2025
Centre Hospitalier de l’Université de Montréal
2014-2025
Établissement Français du Sang
2001-2024
Laboratoire Pacte
2022-2024
Centre Hospitalier Universitaire de Rennes
2014-2024
Groupe de Recherche sur le Psoriasis
2021-2024
Gravitational waves enable tests of general relativity in the highly dynamical and strong-field regime. Using events detected by LIGO-Virgo up to 1 October 2019, we evaluate consistency data with predictions from theory. We first establish that residuals best-fit waveform are consistent detector noise, low- high-frequency parts signals agreement. then consider parametrized modifications varying post-Newtonian phenomenological coefficients, improving past constraints factors ${\sim}2$; also...
<h3>Importance</h3> Single-agent immune checkpoint inhibition has not shown activities in advanced refractory colorectal cancer (CRC), other than those patients who are microsatellite-instability high (MSI-H). <h3>Objective</h3> To evaluate whether combining programmed death-ligand 1 (PD-L1) and cytotoxic T-lymphocyte–associated protein 4 (CTLA-4) improved patient survival metastatic CRC. <h3>Design, Setting, Participants</h3> A randomized phase 2 study was conducted 27 centers across Canada...
Immune checkpoint inhibitors (ICIs) for cancer therapy frequently induce immune-related adverse effects (IRAEs). Therefore, most patients with preexisting autoimmune diseases have been excluded from clinical trials of ICIs. This study was undertaken to evaluate the safety and efficacy ICIs in disease cancer.A retrospective cohort conducted January 2017 2018 via 3 French national networks experts oncology autoimmunity. Adults who were receiving assessed occurrence flare disease, other IRAEs,...
In the era of immunotherapies there is an urgent need to implement use circulating biomarkers in clinical practice facilitate personalized therapy and predict treatment response. We conducted a prospective study evaluate usefulness exosomal-PD-L1 melanoma patients' follow-up. studied dynamics from 100 patients by using enzyme-linked immunosorbent assay. found that PD-L1 was secreted through exosomes cells. Exosomes carrying had immunosuppressive properties since they were as efficient cancer...
The gravitational-wave signal GW190521 is consistent with a binary black hole merger source at redshift 0.8 unusually high component masses, $85^{+21}_{-14}\,M_{\odot}$ and $66^{+17}_{-18}\,M_{\odot}$, compared to previously reported events, shows mild evidence for spin-induced orbital precession. primary falls in the mass gap predicted by (pulsational) pair-instability supernova theory, approximate range $65 - 120\,M_{\odot}$. probability that least one of holes 99.0%. final...
Immune checkpoint blockers (ICB) have become pivotal therapies in the clinical armamentarium against metastatic melanoma (MMel). Given frequency of immune related adverse events and increasing use ICB, predictors response to CTLA-4 and/or PD-1 blockade represent unmet needs. Using a systems biology-based approach an assessment 779 paired blood tumor markers 37 stage III MMel patients, we analyzed association between parameters functional reactivity tumor-infiltrating cells after ex vivo...
Early results at 3 years from the PRODIGE 24/Canadian Cancer Trials Group PA6 randomized clinical trial showed survival benefits with adjuvant treatment modified FOLFIRINOX vs gemcitabine in patients resected pancreatic ductal adenocarcinoma; mature data are now available.To report 5-year outcomes and explore prognostic factors for overall survival.This open-label, phase was conducted 77 hospitals France Canada included aged 18 to 79 histologically confirmed adenocarcinoma who had undergone...
PURPOSE To evaluate first-line pembrolizumab monotherapy efficacy and safety in patients with unresectable cutaneous squamous cell carcinomas (CSCCs). PATIENTS AND METHODS Patients, predominantly men, their CSSCs’ immunohistochemically determined programmed death-ligand 1 (PD-L1) status (tumor proportion score threshold, 1%), received (200 mg every 3 weeks). The primary endpoint was the 39-patient cohort’s objective response rate at week 15 (ORR W15 ). Secondary objectives were best ORR,...
A search for gravitational-wave signals produced by cosmic strings in the Advanced LIGO and Virgo full O3 data set improve upon previous LIGO-Virgo constraints on G\ensuremath{\mu} one to two orders of magnitude, depending model which is tested.
We report the observation of a coalescing compact binary with component masses $2.5\text{-}4.5~M_\odot$ and $1.2\text{-}2.0~M_\odot$ (all measurements quoted at 90% credible level). The gravitational-wave signal GW230529_181500 was observed during fourth observing run LIGO-Virgo-KAGRA detector network on 2023 May 29 by LIGO Livingston Observatory. primary source has mass less than $5~M_\odot$ 99% credibility. cannot definitively determine from data alone whether either is neutron star or...
Background— The Diabetes Atherosclerosis Intervention Study showed that treatment with fenofibrate decreases progression of coronary atherosclerosis in subjects type 2 diabetes. We determined whether on-treatment plasma lipid concentrations and LDL particle size contribute to the favorable effect on artery disease (CAD). Methods Results— A total 418 diabetes were randomly assigned 200 mg micronized daily or placebo. mean follow-up time was 39.6 months. peak diameter (LDL size) by...
The efficacy of low doses certain neuroleptics in improving negative symptoms is still controversial. This study assessed the amisulpride, a benzamide which increases dopaminergic transmission at via presynaptic dopamine receptor blockade, on schizophrenia.The was designed as parallel-group, double-blind, placebo-controlled trial. Patients had to fulfil DSM-III criteria for schizophrenia, Andreasen's and have total score least 75 SANS; those treated with or antidepressants underwent six-week...
External acuminata condylomata (EAC) are among the most common sexually transmitted diseases. Although it is understood that low-risk human papillomavirus (HPV) genotypes 6 and 11 associated with EAC, there have only been a few, small, published studies reporting genotype-specific prevalence of HPV. The objective our study was to assess HPV for large number cases involving both men women evaluate potential benefit quadrivalent (genotypes 6, 11, 16, 18) vaccine in France.A total 256 260 who...