A5090861690- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Autoimmune Bullous Skin Diseases
- Occupational exposure and asthma
- T-cell and B-cell Immunology
- Mast cells and histamine
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Medicine and Dermatology Studies History
- Immune Cell Function and Interaction
- Psoriasis: Treatment and Pathogenesis
- Pharmaceutical studies and practices
- Immunotoxicology and immune responses
- Autoimmune and Inflammatory Disorders
- Eosinophilic Disorders and Syndromes
- Pesticide Exposure and Toxicity
- Pharmacovigilance and Adverse Drug Reactions
- IL-33, ST2, and ILC Pathways
- Complementary and Alternative Medicine Studies
- Biotin and Related Studies
- Monoclonal and Polyclonal Antibodies Research
Inserm
2016-2025
Université Claude Bernard Lyon 1
2016-2025
Centre International de Recherche en Infectiologie
2016-2025
Hôpital Lyon Sud
2015-2025
Hospices Civils de Lyon
2016-2025
Centre National de la Recherche Scientifique
2015-2024
École Normale Supérieure de Lyon
2015-2024
Institute Cancer De La Loire Lucien Neuwirth
2024
RELX Group (United States)
2023
Lyon College
2009-2020
Foxp3-expressing regulatory T cells (Tregs) reside in tissues where they control inflammation and mediate tissue-specific functions. The skin of mice humans contain a large number Tregs; however, the mechanisms how these function remain largely unknown. In this article, we show that Tregs facilitate cutaneous wound healing. Highly activated accumulated early after wounding, specific ablation resulted delayed re-epithelialization kinetics closure. wounded attenuated IFN-γ production...
Abstract Autoimmunity can occur when a checkpoint of self-tolerance fails. The study familial autoimmune diseases reveal pathophysiological mechanisms involved in more common diseases. Here, by whole-exome/genome sequencing we identify heterozygous, autosomal-dominant, germline loss-of-function mutations the SOCS1 gene ten patients from five unrelated families with early onset manifestations. intracellular protein is known to downregulate cytokine signaling inhibiting JAK-STAT pathway....
Skin T regs depend on GATA3 to attenuate immune cell–stimulated cutaneous fibrosis. See the related Focus by Bal and Stadhouders .
Pivotal phase III studies demonstrated that abrocitinib, an oral, once-daily, JAK1-selective inhibitor, is effective treatment for moderate-to-severe atopic dermatitis (AD) as monotherapy and in combination with topical therapy. The aim of this study was to evaluate the long-term safety abrocitinib 200 mg 100 integrated analysis a IIb study, four studies, one extension study. Two cohorts were analyzed: placebo-controlled cohort from 12- 16-week all-abrocitinib including patients who received...
Abstract Background Oxaliplatin-based regimens induce a potential risk of hypersensitivity reaction (HSR), with incidence varying from 10% to 25% and lack clearly identified factors. The present study aimed assess factors in HSR. Methods All patients treated oxaliplatin the Medical Oncology Department Lyon Sud University Hospital (Hospices Civils de Lyon, France) October 2004 January 2011 were enrolled. Incidence severity HSR analyzed retrospectively clinicopathological covariates tested on...
Abrocitinib, an oral, once-daily, Janus kinase 1-selective inhibitor, is efficacious in moderate-to-severe atopic dermatitis with a manageable long-term safety profile. We aimed to provide updated integrated results for abrocitinib from available data accrued up maximum of almost 4 years patients the JADE clinical development program. Analysis included 3802 (exposure: 5213.9 patient-years) phase II monotherapy study (NCT02780167) and III studies MONO-1 (NCT03349060), MONO-2 (NCT03575871),...
Atopic dermatitis (AD) is a common inflammatory disease of the skin, which may have substantial impact on patients' health-related quality life (HRQoL). The aim this study was to quantify economic burden (direct and indirect costs) moderate-to-severe AD evaluate prevalence psychosocial comorbidities among patients in European Union-5 (France, Germany, Italy, Spain, UK). Data were analyzed from 2017 EU5 National Health Wellness Survey. Respondents with physician diagnosis AD/eczema who...
Although ocular adverse events are frequent in AD patients treated with dupilumab, their characterization remains limited due to a lack of prospective studies systematic ophthalmological examination. To examine the incidence, characteristics and risk factors dupilumab-induced events. A prospective, multicenter, real-life study adult dupilumab. At baseline, 27 out 181 (14.9%) had conjunctivitis. week 16 (W16), 25 improved conjunctivitis 2 remained stable 34 (18.7%) blepharoconjunctivitis:...
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare severe adverse drug reaction. Large detailed studies of histopathological features DRESS are sparse suggest an association between keratinocyte damage the severity visceral involvement.To describe dermatopathological in large series their possible clinical disease.A retrospective analysis clinicobiological monocentric cohort patients DRESS.From January 2005 to 2013, 45 were validated as probable or definite cases DRESS....
This study highlights the key role of polycytotoxic CD8 + T cells in severity toxic epidermal necrolysis.
<i>Background:</i> Quinolone hypersensitivity reactions are being more frequently reported. Skin tests in investigations of patients known to not be fully reliable. The provocation test thus remains the gold standard definitive diagnosis allergy, despite risks involved. aim this study was evaluate basophil activation (BATs) immediate-type quinolones. <i>Methods:</i> Thirty-four who presented an hypersensivity reaction less than hour after quinolone administration were...