A5020422384- Contact Dermatitis and Allergies
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Drug-Induced Adverse Reactions
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Food Allergy and Anaphylaxis Research
- Occupational exposure and asthma
- Skin Protection and Aging
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Immunotoxicology and immune responses
- Advancements in Transdermal Drug Delivery
- Monoclonal and Polyclonal Antibodies Research
- Psoriasis: Treatment and Pathogenesis
- Hidradenitis Suppurativa and Treatments
- Pesticide Exposure and Toxicity
- Toxin Mechanisms and Immunotoxins
- Extracellular vesicles in disease
- IL-33, ST2, and ILC Pathways
- Dermatological diseases and infestations
- Eosinophilic Disorders and Syndromes
- Mast cells and histamine
Inserm
2016-2025
Centre International de Recherche en Infectiologie
2016-2025
Université Claude Bernard Lyon 1
2016-2025
Centre National de la Recherche Scientifique
2013-2024
École Normale Supérieure de Lyon
2013-2024
Hôpital Lyon Sud
2006-2024
Institute Cancer De La Loire Lucien Neuwirth
2024
Hospices Civils de Lyon
2007-2023
Université de Lyon
2009-2021
Structure Fédérative de Recherche Biosciences
2005-2010
Allergic contact dermatitis is the most frequent occupational disease in industrialized countries. It caused by CD8+ T cell–mediated hypersensitivity (CHS) reactions triggered at site of a variety chemicals, also known as weak haptens, present fragrances, dyes, metals, preservatives, and drugs. Despite myriad potentially allergenic substances that can penetrate skin, sensitization relatively rare immune tolerance to substance often induced yet poorly understood mechanisms. Here we show,...
Skin lesions in the allergic form of atopic dermatitis (AD) are induced by allergen-specific T cells that infiltrate skin at site allergen exposure. Although Th2-type CD4+ appear to be crucial AD pathophysiology, little is known about contribution CD8+ development inflammation. In present study, we have analyzed respective role and a mouse model allergen-induced AD. sensitized mice, rapidly transiently recruited allergen-exposed initiate inflammatory process leading infiltration with...
Ivermectin (IVM) is widely used in both human and veterinary medicine to treat parasitic infections. Recent reports have suggested that IVM could also anti-inflammatory properties.Here, we investigated the activity of a murine model atopic dermatitis (AD) induced by repeated exposure allergen Dermatophagoides farinae, standard cellular immunological assays.Our results show topical improved allergic skin inflammation reducing priming activation allergen-specific T cells, as well production...
This study highlights the key role of polycytotoxic CD8 + T cells in severity toxic epidermal necrolysis.
Atopic dermatitis (AD) is a common chronic inflammatory skin disease that significantly affects the patient’s quality of life. A disrupted barrier, type 2 cytokine-dominated inflammation, and microbial dysbiosis with increased Staphylococcus aureus colonization are critical components AD pathogenesis. Patients exhibit decreased expression antimicrobial peptides (AMPs) which linked to by . The microbiome itself source several AMPs. These host- microbiome-derived AMPs define landscape based on...
Atopic dermatitis (AD) is a common skin inflammatory disease characterized by the production of thymic stromal lymphopoietin (TSLP) and marked TH 2 polarization. Recent studies suggest that IL-1β contributes to development AD inflammation. Here, we have investigated impact signalling on epidermal homeostasis both healthy subjects patients [with functional filaggrin (FLG) alleles], with particular attention TSLP keratinocyte differentiation. In reconstructed human epidermis (RHE), promoted...
The human skin is known to be inhabited by diverse microbes, including bacteria, fungi, viruses, archaea, and mites. This microbiome exerts a protective role against infections promoting immune development inhibiting pathogenic microbes colonize skin. One of the factors having an intense effect on its resident ultraviolet-radiation (UV-R). UV-R can promote or inhibit growth modulate system which either favorable harmful. Among potential targets, memory T cells (TRM) stand as well positioned...
Abstract Skin metabolites (< 1500 Da) play a critical role in barrier function, hydration, immune response, microbial invasion, and allergen penetration. We aimed to understand the global metabolic profile changes of skin relation microbiome UV exposure exposed germ-free (devoid microbiome), disinfected mice (partially devoid microbiome) control with intact immunosuppressive doses UVB radiation. Targeted untargeted lipidome metabolome profiling was performed tissue by high-resolution mass...
Allergic contact dermatitis, also referred to as hypersensitivity, is one the most frequent inflammatory skin diseases, and characterized by redness, papule vesicles, followed scaling dryness. dermatitis elicited upon with nonprotein chemicals, haptens, corresponds a cutaneous delayed type hypersensitivity reaction, mediated hapten-specific T-cells. During sensitization phase, both CD4(+) CD8(+) T-cell precursors are activated in draining lymph nodes presentation of haptenated peptides...