A5085382022- Ocular Surface and Contact Lens
- Ocular Diseases and Behçet’s Syndrome
- Corneal Surgery and Treatments
- Ocular Infections and Treatments
- Corneal surgery and disorders
- Drug-Induced Adverse Reactions
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Systemic Lupus Erythematosus Research
- Intraocular Surgery and Lenses
- Contact Dermatitis and Allergies
- Autoimmune Bullous Skin Diseases
- Yersinia bacterium, plague, ectoparasites research
- Urticaria and Related Conditions
- Herpesvirus Infections and Treatments
- Mesenchymal stem cell research
- Vasculitis and related conditions
- Legionella and Acanthamoeba research
- Retinal Diseases and Treatments
- Cerebral Venous Sinus Thrombosis
- Ocular Disorders and Treatments
- Allergic Rhinitis and Sensitization
- Mast cells and histamine
- Hepatitis B Virus Studies
- Ophthalmology and Visual Impairment Studies
Université de Rouen Normandie
2016-2025
Hôpital Charles-Nicolle
2015-2025
Centre Hospitalier Universitaire de Rouen
2012-2023
Université de Reims Champagne-Ardenne
2018-2022
Hôpital Charles-Nicolle
2005-2021
Hôpitaux Universitaires Henri-Mondor
2009-2021
Normandie Université
2018
Clinique Ambroise Paré
2018
Paris-Est Sup
2009
Assistance Publique – Hôpitaux de Paris
2009
<h3>Objectives</h3> To describe the acute and late ocular manifestations of toxic epidermal necrosis (TEN), Stevens-Johnson syndrome (SJS), overlap to identify predictors for development complications. <h3>Design</h3> Retrospective cohort study. <h3>Setting</h3> A single referral unit in a university hospital. <h3>Patients</h3> The study included 159 patients (mean [SD] age, 49.9 [19.8] years) with TEN SJS during an 8-year period. Forty-nine were contacted at least 15 months after hospital...
Objective To analyze the factors associated with response to anti–tumor necrosis factor (anti‐TNF) treatment and compare efficacy safety of infliximab (IFX) adalimumab (ADA) in patients refractory noninfectious uveitis. Methods This was a multicenter observational study 160 (39% men 61% women; median age 31 years [interquartile range 21–42]) uveitis that had been other therapies, who were treated anti‐TNF (IFX 5 mg/kg at weeks 0, 2, 6, then every 5–6 [n = 98] or ADA 40 mg 2 62]). Factors...
Neurotrophic keratopathy is a degenerative disease of the corneal epithelium resulting from impaired innervation, possibly leading to perforation. We aimed assess efficacy and tolerance new matrix therapy agent (RGTA, Cacicol20), mimicking heparan sulfates, for management neurotrophic keratopathy.We carried out an uncontrolled, prospective, single-center clinical study on 11 patients (11 eyes) with severe ulcers, despite use preservative-free artificial tears, 15 days. Patients were treated...
<h3>Aims</h3> The aim of this study was to assess the efficacy and safety pre-Descemet9s membrane (DM) sutures associated with intracameral air injection for management acute corneal hydrops keratoconus. <h3>Methods</h3> We carried out a retrospective interventional seven consecutive cases. Three pre-DM 10-0 nylon were applied perpendicularly tear as close possible DM, under general anaesthesia. An bubble injected into anterior chamber at end each procedure. <h3>Results</h3> Corneal oedema...
Epidermal necrolysis (EN) encompasses Stevens-Johnson syndrome (SJS, < 10% of the skin affected), Lyell (toxic epidermal necrolysis, TEN, with ≥30% affected) and an overlap (10 to 29% affected). These rare diseases are caused, in 85% cases, by pharmacological treatments, symptoms occurring 4 28 days after treatment initiation. Mortality is 20 25% during acute phase, almost all patients display disabling sequelae (mostly ocular impairment psychological distress). The objective this French...
Although ocular adverse events are frequent in AD patients treated with dupilumab, their characterization remains limited due to a lack of prospective studies systematic ophthalmological examination. To examine the incidence, characteristics and risk factors dupilumab-induced events. A prospective, multicenter, real-life study adult dupilumab. At baseline, 27 out 181 (14.9%) had conjunctivitis. week 16 (W16), 25 improved conjunctivitis 2 remained stable 34 (18.7%) blepharoconjunctivitis:...
To retrospectively assess the frequency of ocular relapse and possibility long-term remission in patients treated with interferon (IFN) for severe uveitis associated Behçet disease.All were an initial dosage 3 million IU IFN three times a week. The main outcome measure was number relapses per person year before, during, after treatment.Of 36 (67 eyes), 31 (86.1%) responded to IFN. mean follow-up 8.19 years. Twenty-one out discontinued 76% these have not relapsed within 5.05 years...
Background Supportive care is the cornerstone of management adult and paediatric Stevens–Johnson syndrome (SJS) toxic epidermal necrolysis (TEN). However, consensus on modalities supportive lacking. Objectives Our aim in this international multicentric Delphi exercise was to establish a multidisciplinary expert standardize recommendations regarding acute phase SJS/TEN. Methods Participants were sent survey via online tool SurveyMonkey, consisting 103 statements organized into 11 topics: team...
PURPOSE: We report a novel technique which enables to cut any kind of foldable lens and extract it using capsulorhexis forceps 1.2 mm single-use slit angled knife. METHODS: The consists in the mantain stabilize IOL anterior chamber, while one hand holds that way, second introduces knife through paracenthesis cuts on 3/4 his diameter. is then extracted or twe pieces. RESULTS: Since march 2021 we performed 82 eyes 79 patients. Learning curve was very fast easily managed by two experimented...
Purpose: Cyclosporin A (CsA) is a drug used to prevent immune rejection in corneal transplantation. Most grafts performed today are endothelial which complicated with poor penetration of CsA into the endothelium due its hydrophobicity. To improve new ocular formulation 2% Miglyol was developed and commercially available. The purpose this pharmacokinetic study determine concentrations all layers cornea, particular after topical administration 2%-Miglyol rabbits. Methods: Sixteen rabbits were...
To evaluate the demographics, aetiologies, complications, treatments and visual prognoses of chronic recurrent non-infectious paediatric-onset uveitis in France.Descriptive, retrospective bicentric study patients whose disease started before 17 who were followed up two centres from January 2010 to May 2017.We included 147 with 268 affected eyes. Eighty-two had juvenile idiopathic arthritis-associated uveitis, 58 antinuclear antibody (ANA) positive 24 ANA negative, 36 9 enthesitis-related...
Abstract Background Long-term sequelae are frequent and often disabling after epidermal necrolysis (Stevens-Johnson syndrome (SJS) toxic (TEN)). However, consensus on the modalities of management these is lacking. Objectives We conducted an international multicentric DELPHI exercise to establish a multidisciplinary expert standardize recommendations regarding SJS/TEN sequelae. Methods Participants were sent survey via online tool “Survey Monkey” consisting 54 statements organized into 8...