A5052865753- Herpesvirus Infections and Treatments
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Ocular Infections and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Advanced Numerical Methods in Computational Mathematics
- Oceanographic and Atmospheric Processes
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Advanced Mathematical Modeling in Engineering
- Wind and Air Flow Studies
- Ocular Oncology and Treatments
- Fluid Dynamics and Turbulent Flows
- Corneal Surgery and Treatments
- Cerebral Venous Sinus Thrombosis
- Retinal and Macular Surgery
- Meteorological Phenomena and Simulations
- Cellular transport and secretion
- Virus-based gene therapy research
- Acne and Rosacea Treatments and Effects
- Coastal and Marine Dynamics
- Hydrology and Watershed Management Studies
Assistance Publique – Hôpitaux de Paris
2016-2025
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2017-2025
Infectious Disease Models and Innovative Therapies
2017-2025
Université Paris-Saclay
2020-2025
CEA Paris-Saclay
2022-2025
Institut national de recherche en informatique et en automatique
2015-2025
Centre hospitalier national d'ophtalmologie des Quinze-Vingts
2022-2025
Bicêtre Hospital
2015-2024
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2017-2024
Inserm
2017-2024
Importance There is a lack of long-term efficacy and safety data on hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) RNA interference (RNAi) therapeutics in general. This study presents the longest-term to date patisiran for hATTR-PN. Objective To present adults Design, Setting, Participants global open-label extension (OLE) APOLLO randomized clinical trial phase 2 OLE enrolled patients from 43 hospitals or centers across 19 countries between July 2015 August 2017,...
Major human pathologies are caused by nuclear replicative viruses establishing life-long latent infection in their host. During latency the genomes of these intimately interacting with cell nucleus environment. A hallmark herpes simplex virus type 1 (HSV-1) establishment is shutdown lytic genes expression and concomitant induction associated (LAT) transcripts. Although setting up maintenance genetic program most likely dependent on a subtle interplay between viral factors, this remains...
To evaluate the agreement in axial length (AL), keratometry (K), anterior chamber depth (ACD) measurements; intraocular lens (IOL) power calculations; and predictability using a new partial coherence interferometry (PCI) optical biometer (AL-Scan) reference (gold standard) PCI (IOLMaster 500).Service d'Ophtalmologie, Hopital Bicêtre, APHP Université, Paris, France.Evaluation of diagnostic device.One eye consecutive patients scheduled for cataract surgery was measured. Biometry performed with...
Herpes simplex virus 1 (HSV-1) latency establishment is tightly controlled by promyelocytic leukemia (PML) nuclear bodies (NBs) (or ND10), although their exact contribution still elusive. A hallmark of HSV-1 the interaction between latent viral genomes and PML NBs, leading to formation DNA-containing NBs (vDCP NBs), complete silencing HSV-1. Using a replication-defective HSV-1-infected human primary fibroblast model reproducing vDCP combined with an immuno-FISH approach developed detect...
Small fiber neuropathy (SFN) is an important feature of transthyretin familial amyloid polyneuropathy (TTR-FAP). A practical and objective method for the clinical evaluation SFN needed to improve management this disease. In vivo confocal microscopy (IVCM) corneal nerves, a rapid noninvasive technique, may be used as surrogate marker SFN.To determine correlation with IVCM in patients TTR-FAP.A prospective, single-center, cross-sectional controlled study was conducted at French National...
Herpes simplex virus 1 (HSV-1) establishes latency in trigeminal ganglia (TG) sensory neurons of infected individuals. The commitment toward the viral lytic or latent transcriptional program is likely to depend on both and cellular factors, differ among individual neurons. In this study, we used a mouse model HSV-1 infection investigate relationship between genomes nuclear environment terms establishment latency. During acute infection, show two major patterns: replication compartments...
Ocular immunotherapy-related adverse events (IRAEs), although rare, can be sight-threatening. Our objective was to analyze ocular IRAEs diagnosed in France from the marketing of immune checkpoint inhibitors (ICPIs) until June 2021 and review literature. We collected cases 28 patients (36 IRAEs), occurring after an average 17 weeks (±19). Forty-six percent were treated for metastatic melanoma. Anti-PD1 agents responsible 57% IRAEs. Anterior uveitis most common (44%), followed by panuveitis...