A5008464944- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Retinal Diseases and Treatments
- Ocular Infections and Treatments
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Ophthalmology and Eye Disorders
- Intraocular Surgery and Lenses
- Ocular Diseases and Behçet’s Syndrome
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Tracheal and airway disorders
- Biomedical Research and Pathophysiology
- Respiratory viral infections research
- Retinal Imaging and Analysis
- Optical Coherence Tomography Applications
- Retinal and Optic Conditions
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Visual Impairment Studies
- Neonatal Health and Biochemistry
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Retinal and Macular Surgery
Sorbonne Université
2016-2025
Inserm
2016-2025
Institut de la Vision
2016-2025
Centre hospitalier national d'ophtalmologie des Quinze-Vingts
2016-2025
Université Paris-Saclay
2018-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Paris-Est Sup
2018-2025
Centre National de la Recherche Scientifique
2015-2024
Université de Versailles Saint-Quentin-en-Yvelines
2015-2024
Hôpital Ambroise-Paré
2015-2024
Purpose: To update the 2008 International Classification of Corneal Dystrophies (IC3D) incorporating new clinical, histopathologic, and genetic information. Methods: The IC3D reviewed worldwide peer-reviewed articles for information on corneal dystrophies published between 2014. Using this information, dystrophy templates anatomic classification were updated. New confocal photographs added. Results: On basis revisiting cellular origin dystrophy, a modified is proposed consisting (1)...
Cystinosis is caused by mutations in the CTNS gene (17p13.2), which encodes for a lysosomal cystine/proton symporter termed cystinosin. It most common cause of inherited renal Fanconi syndrome young children. Because its rarity, diagnosis and specific treatment cystinosis are frequently delayed, has significant impact on overall prognosis. In this document, we have summarized expert opinions several aspects disease to improve knowledge provide guidance treatment.
Abstract Objectives To describe the true incidence, prenatal detection rate and fetal outcome of congenital diaphragmatic hernia (CDH) in a systematically registered population over an 18‐year period to determine any change trends time. Methods This was retrospective study all cases CDH Central‐Eastern France Birth Defects Registry from 1986 2003. All fetuses infants up 1 year age diagnosed with were registered, including miscarriages later than 22 weeks gestation, stillbirths terminations...
To evaluate the relationship between in vivo confocal microscopic (IVCM) morphology of subbasal corneal nerves, sensitivity, and clinical parameters patients with non-Sjögren dry eye disease (NSDD).Forty-three NSDD 14 healthy age- sex-matched control subjects were included. Each patient underwent an evaluation ocular surface symptoms using Ocular Surface Disease Index (OSDI); tear film break-up time (TBUT); conjunctival staining (Oxford scale); Schirmer test; sensation testing Cochet-Bonnet...
<h3>Aim</h3> To investigate the association between dry eye symptoms and depression in an adult population. <h3>Methods</h3> In this population-based cross-sectional study, a random sample of 1957 subjects from Beijing Eye Study was examined for disease (DED) 2006. All patients completed interviewer-assisted questionnaire on underwent measurement tear break-up time (TBUT), slit-lamp evaluation corneal staining meibomian gland dysfunction (MGD), Schirmer test. 2011, 1456 were evaluated using...
Purpose.: The purpose of this study was to evaluate the relationship between in vivo confocal microscopic (IVCM) morphology subbasal corneal nerves and sensitivity patients with ocular surface disease. Methods.: Ten healthy volunteers (control group), 12 dry eye (dry-eye 14 treated IOP-lowering topical medications (glaucoma group) were included. Central sensation measured using contact Cochet-Bonnet esthesiometer. IVCM cornea performed following parameters analyzed: density, number, width,...
To use in vivo spectral-domain optical coherence tomography (SD-OCT) to measure corneal, limbal, and bulbar conjunctival epithelial thickness.A total of 156 eyes 79 subjects were enrolled four groups: young control (YC group), < 40 years; middle-aged (MAC > patients with dry eye syndrome (KCS group); glaucoma or ocular hypertension treated intraocular pressure (IOP)-lowering medication (G group). The central corneal epithelium (CE) thickness, the limbal (LE) (BCE) thickness quadrants...
Purpose . To detect changes in optic nerve head (ONH) vascularization glaucoma patients using spectral-domain OCT angiography (OCT-A). Material and Method Fifty 30 normal subjects were evaluated with OCT-A (AngioVue®, Optovue). The total ONH vessel density temporal disc measured. Clinical data, visual field (VF) parameters, evaluation (RNFL: retinal fiber layer thickness, GCC: ganglion cell complex rim area) recorded for patients. Correlations among structural VF parameters analyzed. Results...
Human enterovirus D68 (EV-D68) is known to be associated with mild severe respiratory infections. Recent reports in the United States and Canada of acute flaccid paralysis (AFP) children detection EV-D68 samples have raised concerns about aetiological role this EV type neurological disease. This case study first report AFP following infection Europe.
Dry eye disease (DED) is a multifactorial associated with ocular surface inflammation, pain, and nerve abnormalities. We studied the peripheral central neuroinflammatory responses that occur during persistent DED using molecular, cellular, behavioral, electrophysiological approaches.A mouse model of was obtained by unilateral excision extraorbital lachrymal gland (ELG) Harderian (HG) adult female C57BL/6 mice. In vivo tests were conducted at 7, 14, 21 days (d) after surgery. Tear production...
COVID-19 lockdowns have deeply impacted teaching programs. Online has suddenly become the main form of medical education, a that may be used as long pandemic continues. We aimed at analyzing how online was perceived by both teachers and learners to help determine adapt curricula in next few years. An anonymous cross-sectional survey students, pediatric residents, neonatal fellows, their respective conducted between June August 2020 assess feelings about quality, attendance, equivalence,...
Purpose: The aim of this study was to compare, in vivo on a rat model, two different preservatives— benzalkonium chloride (BAC) and polyquaternium-1 (PQ-1)—using new experimental approaches. Methods: Thirty (30) eyes 15 male Lewis rats were used study. Rats randomly divided into five groups instilled twice day for 11 days with eye drops containing concentrations preservatives, 0.1% BAC, 0.5% PQ-1, balanced salt solution (BSS) as control. ocular surface toxicity these preservatives...
purpose. To assess the usefulness of noninvasive combined technologies used to observe ocular surface changes in toxicology studies. methods. Benzalkonium chloride (BAC) at 0.01%, 0.1%, 0.25%, and 0.5% was applied rat corneas for 11 days. The eye evaluated macroscopically from day (D)0 D52. cornea examined with slit lamp, a fluorescein test performed, confocal microscope vivo calculate corneal thickness, score epithelial endothelial defects, quantify stromal inflammation neovascularization....
Congenital pulmonary malformations (CPM) are mostly recognized on prenatal ultrasound scans. In a minority of cases, they may impair breathing at birth. The factors predictive neonatal respiratory distress not well defined, but an understanding these is essential for decisions concerning the need delivery to take place in tertiary care center. aim this study was identify potential predictors neonates with CPM.We selected cases diagnosis hyperechoic and/or cystic lung lesions from RespiRare,...
<h3>Aims</h3> <i>Demodex</i> mites are implicated in several ocular surface diseases such as blepharitis, rosacea and dry eye syndrome. eyelid infestation is classically diagnosed by analysing depilated eyelashes under the light microscope. The use of <i>in vivo</i> confocal microscopy (IVCM) could be an easy way to improve its diagnosis. ability IVCM identify was evaluated compared with classic depilation method. <h3>Methods</h3> Eight healthy subjects, 22 patients syndrome without anterior...
To evaluate tear film osmolarity in patients treated with intraocular pressure-lowering medications.Forty for glaucoma or ocular hypertension (OHT) were consecutively recruited the study. Each patient was asked to complete an evaluation of surface disease symptoms, Ocular Surface Disease Index, and underwent a including measurement osmolarity, Schirmer test, breakup time (TBUT), corneal conjunctival staining.Twenty-four (60%) reported symptoms. Nineteen (47.5%) had ≤308 mOsms/L, 11 (27.5%)...
To analyze retinal and choroidal microvasculature in patients with nonarteritic anterior ischemic optic neuropathy (NAION) by using optical coherence tomography angiography (OCT-A).In this case-control retrospective observational study, atrophic NAION (at least 3 months after onset of symptoms) normal subjects underwent a complete ophthalmic examination including spectral-domain OCT, visual field (VF), OCT-A. Whole en face image vessel density (wiVD) was used to assess blood flow the radial...
Small fiber neuropathy (SFN) is an important feature of transthyretin familial amyloid polyneuropathy (TTR-FAP). A practical and objective method for the clinical evaluation SFN needed to improve management this disease. In vivo confocal microscopy (IVCM) corneal nerves, a rapid noninvasive technique, may be used as surrogate marker SFN.To determine correlation with IVCM in patients TTR-FAP.A prospective, single-center, cross-sectional controlled study was conducted at French National...
To assess the efficacy and safety of a standardized micropulse transscleral diode laser cyclophotocoagulation procedure in refractory glaucoma.Retrospective, interventional study series 37 consecutive patients with glaucoma, cyclodestructive procedure-naive, who underwent from December 2016 to October 2017. A successful treatment was defined as (1) intraocular pressure between 6 18 mm Hg; (2) 20% baseline reduction; (3) no additional glaucoma medications; (4) decrease vision due...