A5085670796- Ocular Oncology and Treatments
- Glaucoma and retinal disorders
- Cutaneous Melanoma Detection and Management
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Corneal Surgery and Treatments
- Ocular Infections and Treatments
- Corneal surgery and disorders
- Nonmelanoma Skin Cancer Studies
- Intraocular Surgery and Lenses
- Cell Adhesion Molecules Research
- Ocular Diseases and Behçet’s Syndrome
- Cancer and Skin Lesions
- Brain Metastases and Treatment
- Immunotherapy and Immune Responses
- Retinal and Macular Surgery
- Glioma Diagnosis and Treatment
- Ocular Surface and Contact Lens
- Cancer-related Molecular Pathways
- Inflammasome and immune disorders
- melanin and skin pigmentation
- Glycosylation and Glycoproteins Research
- Multiple Myeloma Research and Treatments
- Connexins and lens biology
- Ophthalmology and Eye Disorders
Helsinki University Hospital
2016-2025
University of Helsinki
2016-2025
Université de Strasbourg
2024
University of Eastern Finland
2024
Kuopio University Hospital
2024
Bio Tissue (United States)
2024
Hudson Institute
2024
Hospital District of Helsinki and Uusimaa
2019-2023
Santen (Finland)
2018-2023
Universitätsklinik für Augenheilkunde
2019
To investigate the very long-term prognosis of patients with uveal melanoma and clinical characteristics influencing it.Charts, registry data, histopathologic specimens 289 consecutive choroidal ciliary body treated in district Helsinki University Central Hospital, Finland, between 1962 1981 were audited. Definitions for coding cause death adapted from Collaborative Ocular Melanoma Study (COMS). Competing risks taken into account by using cumulative incidence analysis competing regression.Of...
Purpose: To update the 2008 International Classification of Corneal Dystrophies (IC3D) incorporating new clinical, histopathologic, and genetic information. Methods: The IC3D reviewed worldwide peer-reviewed articles for information on corneal dystrophies published between 2014. Using this information, dystrophy templates anatomic classification were updated. New confocal photographs added. Results: On basis revisiting cellular origin dystrophy, a modified is proposed consisting (1)...
PurposeTo present the American Brachytherapy Society (ABS) guidelines for plaque brachytherapy of choroidal melanoma and retinoblastoma.Methods MaterialsAn international multicenter Ophthalmic Oncology Task Force (OOTF) was assembled to include 47 radiation oncologists, medical physicists, ophthalmic oncologists from 10 countries. The ABS-OOTF produced collaborative guidelines, based on their eye cancer–specific clinical experience knowledge literature. This work reviewed approved by ABS...
Purpose: The International Committee for the Classification of Corneal Dystrophies (IC3D) was created in 2005 to develop a new classification system integrating current information on phenotype, histopathology, and genetic analysis. This update is third edition IC3D nomenclature. Methods: Peer-reviewed publications from 2014 2023 were evaluated. used anatomic each 22 standardized templates including level evidence being corneal dystrophy [from category 1 (most evidence) 4 (least evidence)]....
Purpose To refine the anatomic classification and staging of ciliary body choroidal melanomas in TNM classification. Patients Methods Tumor largest basal diameter thickness 7,369 patients were analyzed based on registry data from five ocular oncology centers. T categories derived empirically by dividing into blocks representing 3- × 3-mm fractions. Blocks with similar survival grouped together so that no category comprised a large majority tumors, each was uniform survival, using randomly...
Destruction of the central endothelium rat cornea was produced by mechanical injury, total debridement, or transcorneal freezing. Endothelial repair then studied using specular microscopy, histological staining, pachymetry, and autoradiographic analysis incorporation tritiated thymidine into nuclear DNA. Following an initial process cell slide to cover endothelial defect, extensive cellular division occurred at margins wound, with approximately 45% cells in wound area showing thymidine. An...
Abstract A combination of congenital central nervous, ocular and muscular abnormalities is characteristic muscle—eye—brain disease (MEB), Fukuyama dystrophy (FCMD), Walker‐Warburg syndrome (WWS). The nosological relationship these inherited malformative disorders still unestablished, although the genetic locus for FCMD has been excluded in MEB. We present first postmortem neuropathological study MEB based on 2 male patients. Apart from sharply limited occipital agyric areas, their brain...
Malignant melanoma of the ciliary body and choroid eye is a tumor that disseminates frequently, 50% diagnosed patients die within 10 years. We investigated hypothesis that, by histopathologic analysis arrangement microvessels (i.e., small blood vessels) in loops networks, we might be able to differentiate better those with favorable prognosis from poor prognosis.We conducted population-based, retrospective cohort study melanoma-specific all-cause mortality for 167 consecutive who had an...
Abstract BACKGROUND To identify factors that independently contribute to overall survival in Stage IVB uveal melanoma and subcategorize by prognosis. METHODS Data of 91 consecutive patients who died metastatic 1985–2000 were analyzed Kaplan–Meier Cox regression analysis. Main covariates participation annual review, symptoms, Karnofsky index, burden, liver function tests, age. Time on chemotherapy was modeled as a confounder. A working formulation for staging according predicted designed....