A5085515901- Endometrial and Cervical Cancer Treatments
- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Management of metastatic bone disease
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Lung Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Uterine Myomas and Treatments
- Ear and Head Tumors
- Spine and Intervertebral Disc Pathology
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Sarcoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- Radiation Therapy and Dosimetry
- Neuroscience and Neuropharmacology Research
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
Tokyo National Hospital
2015-2025
Juntendo University
2023-2025
Juntendo University Hospital
2023-2025
Tokushima Red Cross Hospital
2024
Tokushima Prefectural Central Hospital
2024
National Cancer Center Hospital East
2014-2023
National Cancer Center
2013-2022
National Cancer Research Institute
2022
Komatsu (Japan)
2022
National Cancer Centre Japan
2022
PurposeTo present the American Brachytherapy Society (ABS) guidelines for plaque brachytherapy of choroidal melanoma and retinoblastoma.Methods MaterialsAn international multicenter Ophthalmic Oncology Task Force (OOTF) was assembled to include 47 radiation oncologists, medical physicists, ophthalmic oncologists from 10 countries. The ABS-OOTF produced collaborative guidelines, based on their eye cancer–specific clinical experience knowledge literature. This work reviewed approved by ABS...
This study reports the first-in-human use of a linear accelerator-based boron neutron capture therapy (BNCT) system and first treatment patients with scalp-angiosarcoma BNCT.A single-center open-label phase I clinical trial has been conducted using since November 2019. Patients localized node-negative along largest diameter tumor ≤ 15 cm who refused primary surgery chemotherapy were enrolled. After administration boronophenylalanine (BPA), single BNCT maximum dose delivered to skin being 12...
The major stress-inducible heat shock protein 70 (Hsp70) is frequently overexpressed in the cytosol and integrated plasma membrane of tumor cells via lipid anchorage. Following stress such as non-lethal irradiation Hsp70 synthesis up-regulated. Intracellular located known to exert cytoprotective properties, however, less about (m)Hsp70. Herein, we investigate role mHsp70 sensitivity towards sublines that differ their cytosolic and/or levels. isogenic human colon carcinoma CX+ with stable...
In this study, high risk clinical target volumes (HR-CTVs) according to GEC-ESTRO guideline were contoured retrospectively based on CT images taken at the time of high-dose rate intracavitary brachytherapy (HDR-ICBT) and correlation between outcome dose HR-CTV analyzed. Our study population consists 51 patients with cervical cancer (Stages IB-IVA) treated 50 Gy external beam radiotherapy (EBRT) using central shield combined 2–5 times 6 HDR-ICBT or without weekly cisplatin. Dose calculation...
Stereotactic body radiotherapy (SBRT) is a relatively new treatment for liver tumor. Outcomes of SBRT tumors unsuitable ablation or surgical resection were evaluated.
Abstract An accelerator-based boron neutron capture therapy (BNCT) system employing a solid-state Li target can achieve sufficient flux for treatment although the is reduced over lifetime of its target. In this study, reduction was examined in five targets, and model then established to represent flux. each target, observed based on integrated proton charge reached 28% after 2.52 × 10 6 mC delivered system. The calculated acquired by compared measured an charge, mean discrepancies were less...
Abstract Background Contour delineation, a crucial process in radiation oncology, is time-consuming and inaccurate due to inter-observer variation has been critical issue this process. An atlas-based automatic segmentation was developed improve the delineation efficiency reduce variation. Additionally, automated using artificial intelligence (AI) recently become available. In study, auto-segmentations by atlas- AI-based models for Organs at Risk (OAR) patients with prostate head neck cancer...
PURPOSE: To determine if T2 relaxation time measurements with magnetic resonance (MR) imaging in patients Graves ophthalmopathy (GO) can predict response to therapy. MATERIALS AND METHODS: Studied were 84 GO, 27 disease without (GD), and 12 control subjects disease. times of extraocular muscles retrobulbar fat tissue measured. Twenty-five GO treated systemic corticosteroids retroorbital radiation RESULTS: GD the same as those controls but longer (P < .05). all controls. The predicted...
There have been sporadic reports about synchronous as well metachronous gastric adenocarcinoma and primary lymphoma. Many dealt with in mucosa-associated lymphoid tissue lymphoma of stomach. But to our knowledge, there no that document the increased incidence patients diffuse large B-cell This retrospective study was conducted estimate after treatment, especially The cohort 139 treated radiotherapy at hospital. Mean observation period 61.5 months (range: 3.7-124.6 months). Patients profile,...
Stereotactic body radiotherapy (SBRT) is a relatively new treatment for liver tumor. The outcomes of SBRT tumor unfit ablation and surgical resection were evaluated. Liver patients treated with in seven Japanese institutions studied retrospectively. Patients given between 2004 2012 collected. preceded by trans-arterial chemoembolization (TACE) eligible. Seventy-nine hepatocellular carcinoma (HCC) 51 metastatic median biologically effective dose (BED) (α/β = 10 Gy) was 96.3 Gy HCC 105.6...
Locally advanced uterine cervical cancer (LAUCC) with lateral tumor extension may not always be covered adequately by conventional intracavitary brachytherapy (ICBT). Hybrid and interstitial (HBT) seems to an effective alternative improving anatomy-oriented dose optimisation. The purpose of this study was report initial clinical result for LAUCC treated HBT.Between January 2012 November 2015, 42 patients (T1b2-4a) were primary radiation therapy including HBT. Patients distant metastasis...
Perirectal hyaluronate gel injection (HGI) appears to be a promising technique for healthy tissue dose sparing in pelvic radiotherapy. In this analysis, we report our initial experience of HGI gynecologic brachytherapy, focusing on its safety and effectiveness reduction the rectum. Between July 2013 May 2014, 36 patients received primary/salvage brachytherapy. Dosimetric effect analysis was based pre- post-HGI computed tomography dataset registration with corresponding dose-volume histogram...
Purpose of this study was to identify predictors vaginal ulcer after CT based three-dimensional image-guided high-dose-rate interstitial brachytherapy (HDR-ISBT) for gynecologic malignancies. Records were reviewed 44 female (14 with primary disease and 30 recurrence) gynecological malignancies treated HDR-ISBT or without external beam radiation therapy. The applicator insertion performed image guidance by trans-rectal ultrasound CT. median clinical target volume 35.5 ml (2.4-142.1 ml) the...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Murakami N, Kobayashi K, Kato T, et al. The role of interstitial brachytherapy in the management primary radiation therapy for uterine cervical cancer. Journal Contemporary Brachytherapy. 2016;8(5):391-398. doi:10.5114/jcb.2016.62938. APA Murakami, N., Kobayashi, K., Kato, T., Nakamura, S., Wakita, A., & Okamoto, H. (2016). Brachytherapy, 8(5), 391-398. https://doi.org/10.5114/jcb.2016.62938 Chicago Naoya,...
Pretreatment pulmonary interstitial change (PIC) has been indicated as a risk factor of severe radiation pneumonitis (RP) following stereotactic body therapy (SBRT) for early-stage lung cancer, but details its true effect remain unclear. This study aims to evaluate treatment outcomes SBRT stage I non-small cell cancer in patients with PIC. A total 242 are included this (88% male). The median age is 77 years (range, 55–92 years). dose 40–70 Gy administered 4 10 fractions during 4-to-25 day...
An accelerator-based boron neutron capture therapy (BNCT) system that employs a solid-state Li target can achieve sufficient flux derived from the 7Li(p,n) reaction. However, production is complicated by large thermal load expected on target. The relationship between and was examined under various conditions. A structure for consists of basement. Four proton beam profiles were to vary local while maintaining constant total load. efficiency evaluated with respect number protons delivered...
Neuroendocrine carcinoma of the cervix (NECC) is a rare and highly aggressive tumor with no efficient treatment. We examined genetic features NECC identified potential therapeutic targets. A total 272 patients cervical cancer (25 NECC, 180 squamous cell carcinoma, 53 adenocarcinoma, 14 adenosquamous carcinoma) were enrolled. Somatic hotspot mutations in 50 cancer-related genes detected using Ion AmpliSeq Cancer Hotspot Panel v2. Human papillomavirus (HPV)-positivity was by polymerase chain...
Abstract Targeted sequencing for somatic mutations across the hotspots of 50 cancer-related genes was performed using biopsy specimens to investigate whether clinicopathological factors and genomic alterations correlated with prognosis in locally advanced cervical cancer. Seventy patients diagnosed International Federation Obstetrics Gynecology (FIGO) stage III IVA cancer underwent radiotherapy or concurrent chemoradiotherapy at National Cancer Center Hospital between January 2008 December...