A5028292731- Genetics and Physical Performance
- Ocular Oncology and Treatments
- Muscle metabolism and nutrition
- Sports Performance and Training
- Cardiovascular Effects of Exercise
- Muscle Physiology and Disorders
- Retinal Development and Disorders
- Cutaneous Melanoma Detection and Management
- Retinal Diseases and Treatments
- Corneal Surgery and Treatments
- Genetic Associations and Epidemiology
- Glaucoma and retinal disorders
- Lung Cancer Research Studies
- Nonmelanoma Skin Cancer Studies
- Eating Disorders and Behaviors
- Hormonal and reproductive studies
- Adipose Tissue and Metabolism
- Coffee research and impacts
- Brain Metastases and Treatment
- Microbial Community Ecology and Physiology
- melanin and skin pigmentation
- Nutrition, Genetics, and Disease
- Neuroendocrine Tumor Research Advances
- Head and Neck Surgical Oncology
- Corneal surgery and disorders
Federal Medical-Biological Agency
2019-2025
Volga Region State Academy of Physical Culture, Sports and Tourism
2021-2025
Columbia University Irving Medical Center
2024
Saint Petersburg State Electrotechnical University
2024
Eye Cancer Foundation
2009-2022
Russian Academy of Sciences
2000-2022
Duke University
2021
Ophthalmology Associates (United States)
2021
Kazan Federal University
2016-2020
Oncode Institute
2016-2020
PurposeTo present the American Brachytherapy Society (ABS) guidelines for plaque brachytherapy of choroidal melanoma and retinoblastoma.Methods MaterialsAn international multicenter Ophthalmic Oncology Task Force (OOTF) was assembled to include 47 radiation oncologists, medical physicists, ophthalmic oncologists from 10 countries. The ABS-OOTF produced collaborative guidelines, based on their eye cancer–specific clinical experience knowledge literature. This work reviewed approved by ABS...
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor, and no effective treatment available to date. Mouse models of SCLC based on the inactivation Rb1 Trp53 show frequent amplifications Nfib Mycl genes. Here, we report that, although overexpression either transcription factor accelerates tumor growth, NFIB specifically promotes metastatic spread. High levels are associated with expansive growth a poorly differentiated almost exclusively E-cadherin (CDH1)-negative invasive...
PurposeTo assess of the effect local recurrence uveal melanoma on metastasis using a multicenter international tumor registry.DesignRetrospective study an online registry.ParticipantsPatients with diagnosed between 2001 and 2011.MethodsA committee was formed to create patient-specific data fields. Ten subspecialty ophthalmic oncology centers from 4 continents shared data. Patient selection criteria included diagnosis adequate records allow staging by American Joint Committee Cancer (AJCC)...
Purpose To report long-term experience with intravitreal anti–vascular endothelial growth factor treatment for radiation maculopathy. Methods From 2005-2015, 120 consecutive patients underwent anti-VEGF therapy Inclusion criteria included a diagnosis of uveal melanoma treated plaque radiotherapy and subsequent macular vasculopathy (exudate, retinal hemorrhage, intraretinal microangiopathy, neovascularization, edema). Anti-VEGF involved continuous injections in 4- to 12-week intervals doses...
Abstract Skeletal muscle tissue demonstrates global hypermethylation with age. However, methylome changes across the time-course of differentiation in aged human derived cells, and larger coverage arrays have not been undertaken. Using 850K DNA methylation we compared methylomes young (27 ± 4.4 years) (83 4 skeletal that young/aged heterogenous muscle-derived primary cells (HDMCs) over several time points (0, 72 h, 7, 10 days). Aged was hypermethylated tissue, enriched for;...
The substantial decline in skeletal muscle mass, strength, and gait speed is a sign of severe sarcopenia, which may partly depend on genetic risk factors. So far, hundreds genome-wide significant single nucleotide polymorphisms (SNPs) associated with handgrip lean mass walking pace have been identified the UK Biobank cohort; however, their pleiotropic effects all three phenotypes not investigated. By combining summary statistics association studies (GWAS) pace, we 78 independent SNPs (from...
Background Diurnal behavior in humans is governed by the period length of a circadian clock suprachiasmatic nuclei brain hypothalamus. Nevertheless, cell-intrinsic mechanism this present most cells body. We have shown previously that for individuals extreme chronotype ("larks" and "owls"), properties measured human fibroblasts correlated with diurnal behavior. Methodology/Principal Findings In study, we primary taken from normal and, first time, compared it directly physiological vivo same...
Key points We have recently identified that a HECT domain E3 ubiquitin ligase, named UBR5, is altered epigenetically (via DNA methylation) after human skeletal muscle hypertrophy, where its gene expression positively correlated with increasing lean leg mass training and retraining. In the present study we extensively investigate this novel uncharacterised ligase (UBR5) in atrophy, recovery from atrophy injury, anabolism hypertrophy. demonstrated UBR5 was via methylation during atrophy. also...
PurposeTo compare metastasis-related mortality, local treatment failure, and globe salvage after retinoblastoma in countries with different national income levels.DesignInternational, multicenter, registry-based retrospective case series.ParticipantsTwo thousand one hundred ninety patients, 18 ophthalmic oncology centers, 13 on 6 continents.MethodsMulticenter data were pooled from patients enrolled between January 2001 December 2013. Adequate to allow American Joint Committee Cancer staging,...
Pickering, C, Suraci, B, Semenova, EA, Boulygina, Kostryukova, ES, Kulemin, NA, Borisov, OV, Khabibova, SA, Larin, AK, Pavlenko, AV, Lyubaeva, EV, Popov, DV, Lysenko, Vepkhvadze, TF, Lednev, EM, Leońska-Duniec, A, Pająk, Chycki, J, Moska, W, Lulińska-Kuklik, E, Dornowski, M, Maszczyk, Bradley, Kana-ah, Cięszczyk, P, Generozov, and Ahmetov, II. A genome-wide association study of sprint performance in elite youth football players. J Strength Cond Res 33(9): 2344-2351, 2019-Sprint speed is an...
To evaluate the ability of American Joint Committee on Cancer (AJCC) 8th edition to predict local tumor control and globe salvage for children with retinoblastoma (RB).International, multicenter, registry-based retrospective case series.A total 2854 eyes 2097 patients from 18 ophthalmic oncology centers 13 countries over 6 continents.International, data were pooled enrolled between January 2001 December 2013. All RB adequate records allow staging by AJCC criteria follow-up ascertain...
Objective To analyse ocular and systemic findings of patients presenting with metastasis. Methods analysis It is an international, multicentre, internet-enabled, registry-based retrospective data analysis. Patients were diagnosed between 2001 2011. Data included: primary tumour dimensions, extrascleral extension, ciliary body involvement, American Joint Committee on Cancer (AJCC)-tumour, node, metastasis staging, characteristics metastases. Results Of 3610 uveal melanoma, 69 (1.9%; 95% CI...
The aim of the study was to identify genetic variants associated with personal best scores in Turkish track and field athletes compare allelic frequencies between sprint/power endurance controls using a whole-exome sequencing (WES) approach, followed by replication studies independent cohorts. discovery phase involved 60 elite (31 29 endurance) 20 ethnically matched controls. 1132 individuals (115 Russian sprinters, 373 (of which 75 were VO2max measurements), 209 controls, 148 287 Finnish...
Fibroblast growth factor receptor 1 (FGFR1) is frequently amplified in human small-cell lung cancer (SCLC), but its contribution to SCLC and other tumors has remained elusive. Here, we assess the tumorigenic capacity of constitutive-active FGFR1 (FGFR1K656E) with concomitant RB P53 depletion mouse lung. Our results reveal a context-dependent effect FGFR1K656E: it impairs development from CGRPPOS neuroendocrine (NE) cells, which are considered major cell origin SCLC, whereas promotes...
Background: The genetic predisposition to elite athletic performance has been a controversial subject due the underpowered studies and small effect size of identified variants. aims this study were investigate association common single-nucleotide polymorphisms (SNPs) with endurance athlete status in large cohort European athletes using GWAS approach, followed by replication Russian Japanese functional validation metabolomics analysis. Results: 476,728 SNPs Illumina DrugCore Gene chip was...
Whole genome sequencing (WGS) has great potential to explore all possible DNA variants associated with physical performance, psychological traits and health conditions of athletes. Here we present, for the first time, annotation genomic elite athletes, based on WGS 20 Tatar male wrestlers. The maximum number high-quality per sample was over 3.8 M single nucleotide polymorphisms (SNPs) about 0.64 indels. nonsense mutations 148 (SNVs) individual. Athletes' genomes average contained 18.9 SNPs...
Moreland, E, Borisov, OV, Semenova, EA, Larin, AK, Andryushchenko, ON, LB, Generozov, EV, Williams, AG, and Ahmetov, II. Polygenic profile of elite strength athletes. J Strength Cond Res 36(9): 2509-2514, 2022-Strength is a heritable trait with unknown polygenic nature. So far, more than 200 DNA polymorphisms associated strength/power phenotypes have been identified majorly involving nonathletic populations. The aim the present study was to investigate individually in combination association...