A5016594403- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Meningioma and schwannoma management
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Ocular Oncology and Treatments
- Radiation Dose and Imaging
- Acute Myocardial Infarction Research
- Radiation Therapy and Dosimetry
- Cerebrovascular and Carotid Artery Diseases
- Management of metastatic bone disease
- Head and Neck Surgical Oncology
- Advanced MRI Techniques and Applications
- Head and Neck Cancer Studies
- Vascular Malformations Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Pituitary Gland Disorders and Treatments
- Radiopharmaceutical Chemistry and Applications
- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- MRI in cancer diagnosis
- Lung Cancer Research Studies
Emory University
2013-2022
Winship Cancer Institute
2012-2022
Emory University Hospital
1996-2019
Neurological Surgery
2015-2018
Southeast Radiation Oncology Group
2015-2018
Levine Cancer Institute
2015-2018
Smilow Cancer Hospital
2018
Yale University
2018
Rush University
2018
Rush University Medical Center
2017
PurposeTo present the American Brachytherapy Society (ABS) guidelines for plaque brachytherapy of choroidal melanoma and retinoblastoma.Methods MaterialsAn international multicenter Ophthalmic Oncology Task Force (OOTF) was assembled to include 47 radiation oncologists, medical physicists, ophthalmic oncologists from 10 countries. The ABS-OOTF produced collaborative guidelines, based on their eye cancer–specific clinical experience knowledge literature. This work reviewed approved by ABS...
BACKGROUND: Stereotactic radiosurgery (SRS) is an increasingly common modality used with surgery for resectable brain metastases (BM). OBJECTIVE: To present a multi-institutional retrospective comparison of outcomes and toxicities preoperative SRS (Pre-SRS) postoperative (Post-SRS). METHODS: We reviewed the records patients who underwent resection BM either Pre-SRS or Post-SRS alone between 2005 2013 at 2 institutions. dose-reduction strategy based on tumor size, planned within 48 hours....
NRG Oncology/RTOG 9802 (ClinicalTrials.gov Identifier: NCT00003375) is a practice-changing study for patients with WHO low-grade glioma (LGG, grade II), as it was the first to demonstrate survival benefit of adjuvant chemoradiotherapy over radiotherapy. This post hoc sought determine prognostic and predictive impact WHO-defined molecular subgroups corresponding alterations within 9802.IDH1/2 mutations were determined by immunohistochemistry and/or deep sequencing. A custom Ion AmpliSeq panel...
Background Restenosis after percutaneous transluminal coronary angioplasty remains a major limitation of the long-term success this procedure. is form wound healing. Low-dose ionizing radiation has been effective in inhibiting exuberant healing responses variety clinical situations. Methods and Results Vascular neointimal lesions resembling human restenosis were created arteries normal pigs by overstretch balloon injury. To test effect low-dose endovascular gamma on lesion formation,...
In the porcine overstretch injury model of restenosis, endovascular beta-radiation reduces neointima formation. To determine whether this therapy could be applied to patients with coronary artery disease, a special device was developed allow delivery 12 encapsulated 90Sr/Y sources, measuring total 30 mm, various sites within arterial tree. This study designed evaluate feasibility 12, 14, or 16 Gy at 2 mm after balloon angioplasty stenoses native vessels.Delivery attempted in 23 successful...
Background Neointima formation contributing to recurrent stenosis remains a major limitation of percutaneous transluminal angioplasty. Endovascular low-dose γ-irradiation has been shown reduce intimal thickening (hyperplasia) after balloon overstretch injury in pig coronary arteries, model restenosis. The objective this study was determine whether the use β-emitting radioisotope for application would have similar effects and examine dose-response relations with approach. Methods Results...
Recent preclinical and clinical studies indicate that irradiation using ionizing radiation in the dose range of 15 to 30 Gy may reduce occurrence restenosis patients who have undergone an angioplasty. Several delivery systems intravascular brachytherapy been developed deliver doses this with minimal normal tissue toxicity. In late 1995 American Association Physicists Medicine (AAPM) formed a task group investigate these issues report current state art physics. The is presented here.
Stent implantation has been shown to reduce restenosis by establishing a larger lumen but not reducing neointima formation. We have previously that ionizing radiation reduced formation after balloon injury in swine model of restenosis. The purpose this study was determine whether endovascular irradiation the coronary artery before stent would affect formation.Nine normolipemic pigs underwent angiography, and segments left anterior descending circumflex arteries were chosen as targets for...
Background Ionizing radiation has been shown to reduce vascular lesion formation after balloon overstretch injury of pig coronary arteries. The present series experiments examines the mechanism by which this occurs. Methods and Results Balloon was performed on porcine arteries, followed immediately ionizing using either a source train 90 Sr/Y or 192 Ir seeds designed deliver 14 28 Gy at depth 2 mm from source. animals were killed 3, 7, days injury. Bromodeoxyuridine administered 24 hours...
Spinal metastasis is a problem that afflicts many cancer patients. Traditionally, conventional fractionated radiation therapy and/or surgery have been the most common approaches for managing such Through technical advances in radiotherapy, high dose with extremely steep drop off can now be delivered to limited target volume along spine under image-guidance very precision. This procedure, known as stereotactic body radiosurgery, provides technique rapidly treat selected spinal patients...
Hypofractionated Radiosurgery (HR) is a therapeutic option for delivering partial brain radiotherapy (RT) to large metastases or resection cavities otherwise not amenable single fraction radiosurgery (SRS). The use, safety and efficacy of HR well characterized the optimal RT dose-fractionation schedule undefined.Forty-two patients treated with in 3-5 fractions 20 (48%) intact 22 (52%) resected median maximum dimension 3.9 cm (0.8-6.4 cm) between May 2008 August 2011 were reviewed. Twenty-two...
Object. In this study the authors evaluated safety and performance of GliaSite Radiation Therapy System (RTS) in patients with recurrent malignant brain tumors who were undergoing tumor resection. Methods. The is an inflatable balloon catheter that placed resection cavity at time debulking. Low-dose-rate radiation delivered aqueous solution organically bound iodine-125 (Iotrex [sodium 3-( 125 I)-iodo-4-hydroxybenzenesulfonate]), which are temporarily introduced into portion device via a...