A5055203981- Boron Compounds in Chemistry
- Nuclear Physics and Applications
- DNA Repair Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Boron and Carbon Nanomaterials Research
- Microtubule and mitosis dynamics
- Genomics and Chromatin Dynamics
- Medical Imaging Techniques and Applications
- Acute Lymphoblastic Leukemia research
- Machine Learning in Materials Science
- Cancer therapeutics and mechanisms
- Carcinogens and Genotoxicity Assessment
- PARP inhibition in cancer therapy
- Advanced Glycation End Products research
- Cancer-related Molecular Pathways
- S100 Proteins and Annexins
- Porphyrin and Phthalocyanine Chemistry
- Curcumin's Biomedical Applications
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Epigenetics and DNA Methylation
- Calcium signaling and nucleotide metabolism
- Cell death mechanisms and regulation
- Brain Metastases and Treatment
Nagasaki University
2020-2025
Kyoto University
2022-2025
Japan Radioisotope Association
2022-2024
National Cancer Centre Japan
2019-2020
Tokyo Institute of Technology
2014-2015
National Cancer Research Institute
2014
Abstract An accelerator-based boron neutron capture therapy (BNCT) system employing a solid-state Li target can achieve sufficient flux for treatment although the is reduced over lifetime of its target. In this study, reduction was examined in five targets, and model then established to represent flux. each target, observed based on integrated proton charge reached 28% after 2.52 × 10 6 mC delivered system. The calculated acquired by compared measured an charge, mean discrepancies were less...
Abstract Accelerator-based boron neutron capture therapy (BNCT) systems employing a solid-state lithium target indicated the reduction of flux over lifetime target, and its could represent model. This study proposes novel compensatory approach for delivering required fluence validates clinical applicability. The proposed relies on model cumulative sum real-time measurements proton charges. accuracy BNCT using was examined in five Li targets. With approach, be delivered within 3.0%, 1.0% most...
An accelerator-based boron neutron capture therapy (BNCT) system that employs a solid-state Li target can achieve sufficient flux derived from the 7Li(p,n) reaction. However, production is complicated by large thermal load expected on target. The relationship between and was examined under various conditions. A structure for consists of basement. Four proton beam profiles were to vary local while maintaining constant total load. efficiency evaluated with respect number protons delivered...
This study aimed to evaluate the residual radioactivity in mice induced by neutron irradiation with an accelerator-based boron capture therapy (BNCT) system using a solid Li target. The radionuclides and their activities were evaluated high-purity germanium (HP-Ge) detector. saturated of irradiated mouse was estimated assess radiation protection needs for BNCT system. 24Na, 38Cl, 80mBr, 82Br, 56Mn, 42K identified, radioactivities (1.4 ± 0.1) × 102, (2.2 101, (3.4 0.4) 2.8 0.1, 8.0 (3.8 101...
Glioblastoma is the most common and devastating type of malignant brain tumor. We recently found that eribulin suppresses glioma growth in vitro vivo efficiently transferred into mouse tumors at a high concentration. Eribulin non‐taxane microtubule inhibitor approved for breast cancer liposarcoma. Cells arrested M‐phase by chemotherapeutic agents such as inhibitors are highly sensitive to radiation‐induced DNA damage. Several recent case reports have demonstrated clinical benefits combined...
Boron neutron capture therapy (BNCT) is a non-invasive therapeutic technique for treating malignant tumors, however, methods to evaluate its efficacy and adverse reactions are lacking. High mobility group box 1 (HMGB1) an inflammatory molecule released during cell death. Therefore, we aimed investigate HMGB1 as biomarker BNCT response, by examining the early responses of tumor cells 10B-boronophenylalanine (BPA)-based in Kyoto University Nuclear Reactor. Extracellular release was...
Abstract This study aimed to quantify the relative biological effectiveness (RBE) for epithermal neutron beam contaminated with fast neutrons in accelerator-based boron capture therapy (BNCT) system coupled a solid-state lithium target. The experiments were performed National Cancer Center Hospital (NCCH), Tokyo, Japan. Neutron irradiation provided by Intelligence Care Systems (CICS), Inc. was performed. X-ray irradiation, which assigned as reference group, also using medical linear...
Boron neutron capture therapy (BNCT) is a selective radiotherapy based on nuclear reaction that occurs when
XRCC4 is a protein associated with DNA Ligase IV, which thought to join two ends at the final step of double-strand break repair through non-homologous end joining. In response treatment ionizing radiation or damaging agents, undergoes DNA-PK-dependent phosphorylation. Furthermore, Ser260 and Ser320 (or Ser318 in alternatively spliced form) were identified as major phosphorylation sites by purified DNA-PK vitro mass spectrometry. However, it has not been clear whether these are...
XRCC4 (X-ray cross-complementation group 4) is a protein associated with DNA ligase IV, which thought to join two ends at the final step of double-strand break repair through non-homologous end-joining. It has been shown that, in response irradiation or treatment damaging agents, undergoes phosphorylation, requiring DNA-PK. Here we explored possible role ATM, structurally related DNA-PK, regulation XRCC4. The radiosensitizing effects DNA-PK inhibitor and/or ATM were dependent on and did not...
PolyADP-ribosylation is a post-translational modification of proteins, and poly(ADP-ribose) (PAR) polymerase (PARP) family proteins synthesize PAR using NAD as substrate. Poly(ADP-ribose) glycohydrolase (PARG) functions the main enzyme for degradation PAR. In this study, we investigated effects Parg deficiency on tumorigenesis therapeutic efficacy DNA damaging agents, mouse ES cell-derived tumor models. To examine tumorigenesis, Parg+/+ Parg-/- cells were subcutaneously injected into nude...
The radiosensitization of tumor cells is one the promising approaches for enhancing radiation damage to cancer and limiting effects on normal tissue. In this study, we performed a comprehensive screening targets in human lung cell line A549 using an shRNA library identified apolipoprotein B mRNA editing enzyme catalytic subunit 3G (APOBEC3G: A3G) as candidate target. APOBEC3G innate restriction factor that inhibits HIV-1 infection cytidine deaminase. knockdown with siRNA showed increased...