Jane Setterfield
A5061034988- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Oral Health Pathology and Treatment
- Oral and gingival health research
- Platelet Disorders and Treatments
- Drug-Induced Adverse Reactions
- Autoimmune and Inflammatory Disorders
- Eosinophilic Disorders and Syndromes
- Nail Diseases and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Salivary Gland Disorders and Functions
- Head and Neck Cancer Studies
- Immunodeficiency and Autoimmune Disorders
- Genital Health and Disease
- Syphilis Diagnosis and Treatment
- Hair Growth and Disorders
- Pharmaceutical studies and practices
- Contact Dermatitis and Allergies
- Cutaneous lymphoproliferative disorders research
- Skin and Cellular Biology Research
- Cancer and Skin Lesions
- Asthma and respiratory diseases
- Acne and Rosacea Treatments and Effects
King's College London
2015-2024
Guy's and St Thomas' NHS Foundation Trust
2015-2024
St Thomas' Hospital
2005-2024
Guy's Hospital
2003-2023
St John's Hospital
2023
European Clinical Research Infrastructure Network
2023
King's College Hospital
2001-2023
Institute of Dermatology
1998-2020
Imperial College Healthcare NHS Trust
2017
St Mary's Hospital
2017
Pemphigus encompasses a group of life-threatening autoimmune bullous diseases characterized by blisters and erosions the mucous membranes skin. Before era immunosuppressive treatment, pemphigus was almost always fatal. Due to its rarity, only few randomized controlled therapeutic trials are available. Recently, rituximab has been approved as first-line treatment for moderate severe vulgaris in Europe United States.The Autoimmune blistering Task Force European Academy Dermatology Venereology...
Plain language summary available online
Abstract Background Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of skin and mucous membranes. This typically affects elderly presents with itch localized or, frequently, generalized bullous lesions. A subset patients only develops excoriations, prurigo‐like lesions, eczematous and/or urticarial erythematous The disease, which significantly associated neurological disorders, has high morbidity severely impacts quality life. Objectives methodology...
This guideline has been initiated by the task force Autoimmune Blistering Diseases of European Academy Dermatology and Venereology, including physicians from all relevant disciplines patient organizations. It is a S3 consensus-based that systematically reviewed literature on mucous membrane pemphigoid (MMP) in MEDLINE EMBASE databases until June 2019, with no limitations language. While first part this addressed methodology, as well epidemiology, terminology, aetiology, clinical presentation...
Abstract This guideline on mucous membrane pemphigoid (MMP) has been elaborated by the Task Force for Autoimmune Blistering Diseases of European Academy Dermatology and Venereology (EADV) with a contribution physicians from all relevant disciplines patient organizations. It is S3 consensus‐based encompassing systematic review literature until June 2019 in MEDLINE EMBASE databases. first part covers methodology, clinical definition MMP, epidemiology, MMP subtypes, immunopathological...
Frontal fibrosing alopecia (FFA) is a recently described inflammatory and scarring type of hair loss affecting almost exclusively women. Despite dramatic recent increase in incidence the aetiopathogenesis FFA remains unknown. We undertake genome-wide association studies females from UK cohort, comprising 844 cases 3,760 controls, Spanish cohort 172 385 perform statistical meta-analysis. observe significant with at four genomic loci: 2p22.2, 6p21.1, 8q24.22 15q2.1. Within 6p21.1 locus,...
Abstract Background Paraneoplastic pemphigus (PNP), also called paraneoplastic autoimmune multiorgan syndrome (PAMS), is a rare disease with mucocutaneous and multi‐organ involvement. PNP/PAMS typically associated lymphoproliferative or haematological malignancies, less frequently solid malignancies. The mortality rate of elevated owing to the increased risk severe infections disease‐associated complications, such as bronchiolitis obliterans. Objectives These guidelines summarize...
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction. To our knowledge, there no international consensus on its severity assessment treatment.
Abstract Introduction Linear IgA dermatosis (LAD) is a rare subepidermal autoimmune bullous disease (AIBD) defined by predominant or exclusive immune deposits of immunoglobulin A at the basement membrane zone skin mucous membranes. This disorder rare, clinically and immunologically heterogeneous occurring both in children adults. The aim this project to present main clinical features LAD, propose diagnostic algorithm provide management guidelines based primarily on experts' opinion because...
Mucous membrane pemphigoid (MMP) is an autoimmune blistering disease frequently associated with scarring of involved clinical sites. At present, therapeutic intervention in the form immunomodulating or immunosuppressive agents often reserved until onset significant inflammation and/or early cicatrization. We have therefore studied and immunopathological findings 67 patients MMP order to try establish a reliable prognostic indicator by which at high risk may be identified disease. Inclusion...
Background Mucous membrane pemphigoid (MMP), a chronic autoimmune subepithelial blistering disease, is associated with circulating IgG and/or IgA autoantibodies against several basement zone antigens. The heterogeneity of clinical presentation and diversity target autoantigens have contributed to difficulties in characterizing this condition immunologically. Objectives To analyse serum autoantibody profile HLA class II alleles MMP patients correlate the disease. Methods Well‐defined...
Background To date, there is only weak evidence for the superiority of any interventions over placebo palliation symptomatic oral lichen planus (LP). Further research involving large placebo-controlled, randomized clinical trials needed. These will require carefully selected and standardized outcome measures. Objectives formulate a scoring system intraoral LP. Methods One hundred fifty-six patients with biopsy-confirmed LP were scored at first subsequent visits according to (i) extent site...
BackgroundAccepted 'standard practice' for the diagnosis of immunobullous disease is a perilesional sample direct immunofluorescence (DIF).
Abstract Introduction Dermatitis herpetiformis (DH) is a chronic, pruritic, gluten‐induced skin disorder characterized by subepidermal granular IgA deposition and variable degree of enteropathy identical to that seen in coeliac disease. So far, there has been no European consensus about the management DH. Methods The guidelines were created small subgroups guideline committee consisting 26 specialists from various medical fields one patients’ representative. members then discussed voted for...
Class I human leucocyte antigens (HLA) -A, -B, -Cw and class II HLA-DRB1, -DQB1 alleles were determined in 131 British Caucasian patients with mucous membrane pemphigoid (MMP) using serological DNA-based methods.To analyse the expressed well-defined clinical immunopathological subgroups of MMP, order to establish whether specific or haplotypes might part explain disease susceptibility, sites involvement severity.Subgroups analysed according following criteria: age onset, sex, (oral, ocular,...