A5018293717- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Eosinophilic Disorders and Syndromes
- Immune Cell Function and Interaction
- Autoimmune Bullous Skin Diseases
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Cancer and Skin Lesions
- Skin Diseases and Diabetes
- Immunodeficiency and Autoimmune Disorders
- Nail Diseases and Treatments
- Contact Dermatitis and Allergies
- Cytomegalovirus and herpesvirus research
- Dermatology and Skin Diseases
- Autoimmune and Inflammatory Disorders
- Genetic and rare skin diseases.
- Asthma and respiratory diseases
- Systemic Sclerosis and Related Diseases
- Fungal Infections and Studies
- Cutaneous Melanoma Detection and Management
- Viral-associated cancers and disorders
- Histiocytic Disorders and Treatments
Nara Medical University
2016-2025
Nara Medical University Hospital
2022
Center for Cancer Research
2011-2013
National Institutes of Health
2004-2013
National Cancer Institute
2009-2013
Shiga University of Medical Science
2000-2002
Kyoto University
2001
4F2, also termed CD98, is an integral membrane protein consisting of a heavy chain linked to light by disulfide bond. We have generated monoclonal antibody the mouse 4F2 and cloned cDNA. It encodes counterpart rat L-type amino acid transporter-1, induces system L transport in <i>Xenopus</i> oocytes presence chain. Transfection studies mammalian cells indicated that expressed on plasma its own, whereas can be transported surface only diffusely fibroblastic cells, it localized selectively...
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction. To our knowledge, there no international consensus on its severity assessment treatment.
Abstract Human γδ T cells respond to nonpeptide Ags such as pyrophosphomonoesters and alkylamines in a TCR-dependent manner the absence of other APCs. Recently, aminobisphosphonates pamidronate have also been shown activate human cells. In present study, we indicate that activation primary by strictly depends on presence monocyte-lineage cells, unlike pyrophosphomonoesters. Thus, although induced cell clustering, proliferation, IFN-γ production culture PBMC, it failed induce any these...
Abstract Human Vγ2/Vδ2+ γδ T cells respond to low molecular-mass nonpeptide Ags in a TCR-dependent manner. Although requirements of Ag presentation have remained controversial, we indicated that specific responses the primary pamidronate were dependent on monocytic adherent for presentation. Here, show human tumor can efficiently present aminobisphosphonate and pyrophosphomonoester compounds cells, inducing proliferation IFN-γ production. TCR dependency response Ag-pulsed was confirmed by...
We recently demonstrated that differentiation of cytotoxic T cells requires cooperation between T-cell receptor (TCR)/costimulation and γc-cytokines. Here we demonstrate the transcription factor IFN regulatory 8 (IRF8) is expressed in CD8 by combination these two signals. More importantly, depletion IRF8 abrogated naive into effector an experimental graft-vs.-host disease mouse model. also show seems to not operate upstream other critical factors such as T-bet eomesodermin, which have been...
Abstract Stevens– J ohnson syndrome ( SJS ) and toxic epidermal necrolysis TEN are rare life‐threatening cutaneous adverse drug reactions. While there is no established therapy for / , systemic corticosteroids, plasma exchange i.v. immunoglobulin IVIG have been used as treatment. The efficacy of still controversial because total doses vary greatly from one study to another. aim this was evaluate the administrated 5 days consecutively, in an open‐label, multicenter, single‐arm patients with...
Abstract Drug‐induced hypersensitivity syndrome (DIHS) is one of the severe drug eruptions accompanied by fever and multiple organ dysfunction, it induced a relatively limited range drugs, including anticonvulsants. A distinctive feature this condition its association with reactivation herpes viruses, particularly human herpesvirus 6. The pathogenesis involves two key factors: allergy reactivation. DIHS often challenging to diagnose in early stages, clinical course varies widely, ranging...
Human gammadelta T cells display unique repertoires of Ag specificities largely imposed by selective usages distinct Vgamma and Vdelta genes. Among them, Vgamma2/Vdelta2(+) predominate in the circulation healthy adults respond to various microbial small molecular mass nonpeptide Ags. The present results indicate that primary stimulated with groups Ags, including monoethyl pyrophosphate, isobutyl amine, aminobisphosphonate, invariably exhibit Jgamma1.2 Vgamma2(+) TCR-gamma chains. Gene...
We previously developed a drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) severity (DDS) score that may predict DIHS/DRESS-associated complications (DACs), including myocarditis, gastrointestinal bleeding, autoimmune diseases.To externally confirm the predictive accuracy of DDS score, clarify its ability to identify patients at high risk DACs fatal outcome, determine which treatments might reduce or increase risk.We conducted...
Cutaneous sinus tracts of dental origin are frequently misdiagnosed and incorrectly treated. Intraoral roentgenograms valuable for diagnosing such tracts. Since these lesions usually not accompanied by symptoms, patients tend initially to consult dermatologists or general physicians, who familiar with oral diseases intraoral X-rays. We sought determine the usefulness ultrasonography detecting cutaneous origin. Three had skin that were suspected being based on findings clinical histological...
Fig. 1.Clinical appearance at onset.(a) Oedematous erythema with scale on the face and pallor around eyes.