A5066679243- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatology and Skin Diseases
- Drug-Induced Adverse Reactions
- Skin and Cellular Biology Research
- Herpesvirus Infections and Treatments
- Platelet Disorders and Treatments
- melanin and skin pigmentation
- Allergic Rhinitis and Sensitization
- Chronic Lymphocytic Leukemia Research
- Contact Dermatitis and Allergies
- Nail Diseases and Treatments
- Cytomegalovirus and herpesvirus research
- Psoriasis: Treatment and Pathogenesis
- Viral-associated cancers and disorders
- Mast cells and histamine
- Fungal Infections and Studies
- Cancer and Skin Lesions
- Lymphoma Diagnosis and Treatment
- Asthma and respiratory diseases
- Wnt/β-catenin signaling in development and cancer
- Sympathectomy and Hyperhidrosis Treatments
- Eosinophilic Disorders and Syndromes
- Glycosylation and Glycoproteins Research
Kawasaki Medical School
2016-2025
Okayama Prefecture
2024
Japanese Urological Association
2024
Kawasaki Medical School Hospital
2017-2023
Shinko Hospital
2017-2022
Tokyo Women's Medical University
2018-2021
Inje University Sanggye Paik Hospital
2021
Tokyo Women's Medical University Adachi Medical Center
2020
Okayama University
2008-2018
Metabolism and Renal Physiology
2018
Abstract Generalized pustular psoriasis ( GPP ) is a rare disease characterized by recurrent fever and systemic flushing accompanied extensive sterile pustules. The committee of the guidelines was founded as collaborative project between Japanese Dermatological Association Study Group for Rare Intractable Skin Diseases under Ministry Health, Labour, Welfare Research Project on Overcoming Diseases. aim to provide current information aid in treatment patients with Japan. Its contents include...
Abstract Drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms ( DIHS / DRESS ) is a severe adverse drug caused by specific drug. It characterized visceral organ involvement reactivation of various human herpesviruses. Although sporadic reports have documented certain conditions that appear after the resolution , little information available on sequelae in large patient population. The A sian Research Committee Severe Cutaneous Adverse Reactions,...
The Nek family of protein kinases in humans is composed 11 members that share an amino-terminal catalytic domain related to NIMA, Aspergillus kinase involved the control several aspects mitosis, and divergent carboxyl-terminal tails varying length. Nek6 (314AA) Nek7 (303AA), 76% identical, have little noncatalytic sequence but bind tail Nercc1/Nek9, a NIMA activated mitosis. Microinjection anti-Nercc1 antibodies leads spindle abnormalities prometaphase arrest or chromosome missegregation....
The Rho GTPase and Fyn tyrosine kinase have been implicated previously in positive control of keratinocyte cell–cell adhesion. Here, we show that operate along the same signaling pathway. Endogenous activity increases differentiating keratinocytes is required for both activation increased phosphorylation β- γ-catenin, which associated with establishment Conversely, expression constitutive active sufficient to promote adhesion through a kinase- Fyn-dependent mechanism, trigger activation,...
A form of cytochrome P-450 catalyzing lanosterol 14a-demethylation (tentatively called 'P'45014DMn) was purified from microsomes semi-anaerobically grown cells Saccharomyces cerevisiae to gel electrophoreitc homogeneity.An apparent monomeric M. = 58,000 estimated for the by sodium dodecyl sulfate-polyacrylamide electrophoresis.Both optical and EPR spectra oxidized P-45Ol4n~ are characteristic low spin ferric heme proteins, its reduced CO complex showed a Soret absorption peak at 447 nm.As in...
We found CARD14 mutations (2 de novo novel and another previously reported mutation) in 3 of patients with pityriasis rubra pilaris (PRP) type V, but not PRP other types. Our findings, combined the published literature, suggest that V PRP, both familial sporadic, can be caused by mutations. Detailed clinical observation revealed all displayed unique patchy macular brown hyperpigmentation.To further determine how often have pathogenic to elucidate which subtype is mutations.We sequenced...
Abstract The pemphigoid group is a category of autoimmune subepidermal blistering diseases in which autoantibodies deposit linearly at the epidermal basement membrane zone ( BMZ ). main subtypes mediated by immunoglobulin G are bullous BP ), mucous MMP ) and epidermolysis bullosa acquisita EBA To establish first guidelines approved Japanese Dermatological Association for management diseases, Committee Guidelines Management Pemphigoid Diseases (Including was founded as part Study Group Rare...
Pemphigus vulgaris (PV) is an autoimmune blistering skin disease, which characterized by autoantibodies to a specific desmosomal constituent, i.e. desmoglein 3 (Dsg3). In this study, we analyzed phosphorylation of proteins and their molecular interactions after PV-IgG binding Dsg3 using DJM-1 cells, squamous cell carcinoma line, normal human keratinocytes. Cells were metabolically labeled with 32 P inorganic phosphate, followed stimulation the IgG fractions from five PV patients or...
Pemphigus vulgaris (PV) is an autoimmune blistering disease, characterized by the loss of cell-cell adhesion between epidermal keratinocytes and presence autoantibody against desmoglein 3 (Dsg3), which provides adhesive integrity to desmosomes adjacent keratinocytes. We have previously shown that PV-IgG purified from patients depletes Dsg3. However, contains not only antibodies a variety different epitopes Dsg3 but also other unknown antigens. Therefore, we examined whether Dsg3-depleting...
L-Threonine dehydrogenase (L-threonine:NAD' oxidoreductase (EC 1.1.1.103))has been purified to apparent homogeneity from chicken liver mitochondria.The presence of 2-mercaptoethanol and glycerol is necessary for stabilizing the enzyme during purification storage.The a monomer has M, 88,000.The pH optimum 8.6 8.7, isoelectric point 5.9.The specific L-threonine NAD+.The K,,, values NAD' are 8.4 0.98 m, respectively.Kinetic studies indicate that reaction proceeds through an Ordered Bi mechanism...
Journal Article Survival rates and prognostic factors of Epstein–Barr virus‐associated hydroa vacciniforme hypersensitivity to mosquito bites Get access T. Miyake, Miyake Department Dermatology Okayama University Graduate School Medicine, Dentistry Pharmaceutical Sciences 2‐5‐1 Shikata‐cho Kita‐ku 700‐8558 Japan Search for other works by this author on: Oxford Academic Google Scholar Yamamoto, Yamamoto JapanDepartment Kawasaki Medical Y. Hirai, Hirai M. Otsuka, Otsuka Hamada, Hamada K....
Bullous pemphigoid (BP) is an autoimmune blistering skin disease induced by pathogenic autoantibodies against a type II transmembrane protein (BP180, collagen XVII, or BPAG2). In animal models, BP180 autoantibody-antigen interaction appears insufficient to develop blisters, but involvement of complement and neutrophils required. However, cultured keratinocytes treated with BP-IgG exhibit reduction in the adhesive strength loss expression BP180, suggesting that directly affect epidermal...
Pemphigus is a group of autoimmune blistering diseases that affect the skin and mucous membranes. A reliable accurate disease severity tool to assess pemphigus crucial for managing clinical trials. The purpose this study was compare area index activity score (PDAI), Japanese (JPDSS) physician's subjective impression, also find appropriate grading cut-offs PDAI. We evaluated correlation between PDAI JPDSS. Thirty-seven patients 110 assessments were analyzed in study. optimal points were: mild...
Abstract Because some users develop depigmentation after the use of melanogenesis‐inhibiting products containing quasi‐drug ingredient Rhododenol, Japanese Dermatological Association (JDA) established a Special Committee on Safety Cosmetics Containing Rhododenol July 17, 2013 and management guide for dermatologists has been updated website in order to delineate diagnostic criteria Rhododenol‐induced leukoderma provides broad standard treatment based current knowledge. This is produced basis...
Abstract Stevens– J ohnson syndrome ( SJS ) and toxic epidermal necrolysis TEN are rare life‐threatening cutaneous adverse drug reactions. While there is no established therapy for / , systemic corticosteroids, plasma exchange i.v. immunoglobulin IVIG have been used as treatment. The efficacy of still controversial because total doses vary greatly from one study to another. aim this was evaluate the administrated 5 days consecutively, in an open‐label, multicenter, single‐arm patients with...
Background Exposure to sweating stimuli triggers transient and severe dermal pain in certain individuals. This study aimed evaluate the analgesic effect of icatibant, a bradykinin B2 receptor antagonist, for induced by explored role its pathomechanism. Methods single-blind, randomized, crossover enrolled adult patients who had experienced sweating-induced pain. Participants randomly received icatibant (30 mg) or placebo on Day 1 vice versa 2. Before after drug administration, an artificial...