A5008038602- Dermatologic Treatments and Research
- Photodynamic Therapy Research Studies
- Cancer and Skin Lesions
- Nanoplatforms for cancer theranostics
- melanin and skin pigmentation
- Optical Imaging and Spectroscopy Techniques
- Nail Diseases and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Nonmelanoma Skin Cancer Studies
- Cleft Lip and Palate Research
- Orthopedic Surgery and Rehabilitation
- Mesenchymal stem cell research
- Ocular Infections and Treatments
- Nasal Surgery and Airway Studies
- Sarcoma Diagnosis and Treatment
- Laser Applications in Dentistry and Medicine
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- Facial Trauma and Fracture Management
- Autoimmune Bullous Skin Diseases
- Skin Protection and Aging
- Genetic and rare skin diseases.
- Craniofacial Disorders and Treatments
- Optical Coherence Tomography Applications
- Photoacoustic and Ultrasonic Imaging
Osaka Metropolitan University
2022-2025
Tokyo Metropolitan University
2023-2024
Osaka City University
2011-2021
Ishikiriseiki Hospital
2001-2014
Yokohama City University
2008-2013
Sysmex (Japan)
2004-2011
Yokohama City University Hospital
2008
Kyorin University
2008
Center For Reconstructive Urethral Surgery
2006
Tenri Hospital
2001-2004
Significance: In laser therapy and diagnosis of skin diseases, the irradiated light distribution, which is determined by absorption coefficient μa reduced scattering μs′ epidermis, dermis, subcutaneous fat, affects treatment outcome accuracy. Although values for have been reported, detailed analysis Asian tissues still lacking. Aim: We present measurements in 400- to 1100-nm wavelength range evaluating optical penetration depth energy deposition. Approach: The with human samples are...
Bacterial resistance to antibiotics has become a worldwide problem. One potential alternative for bacterial control is photodynamic therapy. 5-aminolevulinic acid natural precursor of the photosensitizer protoporphyrin IX. Relatively little known about antibacterial efficacy therapy using systemic administration acid; few reports have shown that exerts effects on methicillin-resistant Staphylococcus aureus (MRSA) in vitro. In this study, we evaluated effectiveness and 410-nm wavelength...
Bullous pemphigoid (BP) is an autoimmune blistering skin disease induced by pathogenic autoantibodies against a type II transmembrane protein (BP180, collagen XVII, or BPAG2). In animal models, BP180 autoantibody-antigen interaction appears insufficient to develop blisters, but involvement of complement and neutrophils required. However, cultured keratinocytes treated with BP-IgG exhibit reduction in the adhesive strength loss expression BP180, suggesting that directly affect epidermal...
<title>Abstract</title> <bold>Purpose: </bold>Short-pulsed lasers provide safe and efficacious treatment of pigmented lesions by setting irradiation parameters based on immediate whitening resulting from vacuolization. However, visual observation this phenomenon as an endpoint is subjective makes it difficult to assess the depth which light response induced inside skin. To quantitatively understand dependence parameters, study analyzes spatial distribution light-melanosome interaction...
Human adipose-derived mesenchymal stromal cells (hASCs) are attractive for regenerative medicine, but their limited in vitro life span limits therapeutic applicability. Recent data demonstrate that hypoxia may benefit the ex vivo culture of stem cells. Such exhibit a high level glycolytic metabolism under hypoxic conditions. However, physiological role activation and its underlying regulatory mechanism incompletely understood. We have shown when activated conditions 5% O2, Notch signaling...
Human adipose tissue-derived multilineage progenitor cells (hADMPCs) are attractive for cell therapy and tissue engineering because of their multipotency ease isolation without serial ethical issues. However, limited in vitro lifespan culture systems hinders therapeutic application. Some somatic stem cells, including hADMPCs, known to be localized hypoxic regions; thus, hypoxia may beneficial ex vivo these cells. These exhibit a high level glycolytic metabolism the presence oxygen levels...
Although long noncoding RNAs (lncRNAs) are transcripts that do not encode proteins by definition, some lncRNAs actually contain small open reading frames translated. TINCR (terminal differentiation–induced ncRNA) has been recognized as a lncRNA contributes to keratinocyte differentiation. However, we here show encodes ubiquitin-like protein is well conserved among species and whose expression was confirmed the generation of mice harboring FLAG epitope tag sequence in endogenous frame...
Abstract Background and Objectives A threshold fluence for melanosome disruption has the potential to provide a robust numerical indicator establishing clinical endpoints pigmented lesion treatment using picosecond laser. Although thresholds 755‐nm laser were previously reported, wavelength dependence not been investigated. In this study, wavelength‐dependent fluences determined. Using mathematical model based on thresholds, irradiation parameters 532‐, 730‐, 755‐, 785‐, 1064‐nm treatments...
Abstract Bitter taste receptors (TAS2Rs) are not only expressed in the oral cavity but also skin. Extraoral TAS2Rs thought to be involved non‐taste perception and tissue‐specific functions. Keratinocytes that express skin provide a first‐line defense against external threats. However, functional roles of these host remain unclear. Here, we demonstrated sensory role intracellularly located toxic substances keratinocytes. Although many G protein‐coupled elicit signals from surface, were found...
Background: Port wine stains (PWSs) are commonly treated with pulsed dye laser (PDL) as a standard therapy.However, it is not easy to predict the minimal effective dose in first treatment session.Objective: The aim of this study was assess whether dermoscopic findings before and after irradiation corresponded clinical improvement PWS patients undergoing PDL therapy.Methods: Seven untreated PWSs 6 (a male 5 females), who presented our hospital between May 2008 January 2010, were assessed...
Abstract Signal transducer and activator of transcription 3 (STAT3) is involved in many biological processes, including immunity cancer. STAT3 becomes phosphorylated at Tyr705 Ser727 on IL-6 stimulation. Phospho-Tyr705 (pY705) stabilizes the dimer with reciprocal interactions between pY705 SH2 other molecule phospho-Ser727 (pS727) accelerates dephosphorylation. We study how pS727 regulates both structural perspectives. Using reconstituted HepG2-stat3-knockout cells, we show that pS727,...
Merkel cell carcinoma (MCC) is a rare and highly malignant skin cancer. Some cases have good prognosis spontaneous regression can occur. Reported prognostic markers, such as polyoma virus infection or programmed death ligand-1 (PD-L1) expression, remain insufficient for precisely estimating the vastly different patient outcomes. We performed RNA sequencing to evaluate immune response comprehensively estimate values of immunogenic factors in patients with MCC.We collected 90 specimens from 71...
Ingrown toenail is a common nail disease that causes pain, discomfort, and difficulty in walking. It treated with either conservative therapy or surgery.To present new surgical approach to ingrown toenail.For 19 borders of 14 toes patients (1 male 13 females), the matrix was stained methylene blue then partial matricectomy performed CO2 laser.There no recurrence at 18 after mean follow-up period 13.4 months, whereas spike grew one border but caused walking pain. No serious complications...
Pigmentation in the dermis is known to be caused by melanophages, defined as melanosome-laden macrophages. In this study, we show that dermal fibroblasts also have an ability uptake melanosomes and apoptotic melanocytes. We previously demonstrated normal human melanocytes constantly secrete melanosome clusters from various sites of their dendrites. After adding secreted collected culture medium melanocytes, time-lapse imaging showed actively attached incorporated them. Annexin V staining...
Nasal fractures are the most common facial fracture in children and adults. Generally, it is believed that reduction of pediatric nasal more difficult should be performed earlier compared with adult fracture. However, there has been no article to prove this theory. We investigated 423 patients acute requiring surgery divided them into following 2 groups: 12 years younger (pediatric group) 13 older (adult group). then these various aspects. There were significant differences cause or...
Preauricular transparotid approach without dissecting the facial nerve was used for surgical treatment of 15 condylar fractures in 14 patients. The parotid fascia opened just above fracture site, and by gland masseter muscle, directly exposed. itself not dissected expressly. All could be reduced accurately fixed firmly with miniplates. A direct site provided good vision fracture, avoiding palsy caused strong retraction. Moreover, nerve, operation time shortened. This useful both neck...