A5028839003- Autoimmune Bullous Skin Diseases
- Skin and Cellular Biology Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Cancer and Skin Lesions
- Muscle Physiology and Disorders
- Nail Diseases and Treatments
- Dermatologic Treatments and Research
- Systemic Sclerosis and Related Diseases
- Hair Growth and Disorders
- Platelet Disorders and Treatments
- Dermatological and Skeletal Disorders
- Ubiquitin and proteasome pathways
- Regulation of Appetite and Obesity
- Polysaccharides and Plant Cell Walls
- Nonmelanoma Skin Cancer Studies
- Antifungal resistance and susceptibility
- Dermatology and Skin Diseases
- Plant Pathogens and Fungal Diseases
- Vascular Tumors and Angiosarcomas
- Fungal Infections and Studies
- Inflammatory Myopathies and Dermatomyositis
- melanin and skin pigmentation
- Chemical Synthesis and Analysis
- Oral Health Pathology and Treatment
Hiroshima University
2020-2025
Saitama International Medical Center
2024-2025
Kumamoto University
2020-2024
Nagasaki University
2016-2021
Aizawa Hospital
2009-2019
Tohoku University
2012-2019
Japan Society for the Promotion of Science
2017-2018
Cells Therapy (Poland)
2018
StemCells (United States)
2018
Gifu University
2005-2015
Three different approaches were used to investigate the role of extracellular phospholipases in pathogenicity Candida albicans. First, we compared 11 blood isolates this yeast with an equal number commensal strains isolated from oral cavities healthy volunteers. Blood produced significantly more phospholipase activity than did. Second, two clinical C. albicans that differed their levels virulence a newborn mouse model for ability secrete phospholipases. The invasive strain noninvasive Third,...
In this study, we report the purification, cDNA cloning, and characterization of novel growth hormone-releasing peptide, ghrelin, in chicken (Gallus gallus). Chicken ghrelin is composed 26 amino acids (GSSFLSPTYKNIQQQKDTRKPTARLH) possesses 54% sequence identity with human ghrelin. The serine residue at position 3 (Ser(3)) conserved between mammalian species, as its acylation by either n-octanoic or n-decanoic acid. mRNA predominantly expressed stomach, where it present proventriculus but...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular control of membrane properties during temperature acclimation. Fatty acid desaturase regulation fluidity in acclimating Tetrahymena cellsCharles E. Martin, Kayoko Hiramitsu, Yasuo Kitajima, Yoshinori Nozawa, Lars Skriver, and Guy A. Thompson, Jr.Cite this: Biochemistry 1976, 15, 24, 5218–5227Publication Date (Print):November 1, 1976Publication History Published online1 May 2002Published inissue 1 November...
Nrf2 (NF-E2-related factor 2) contributes to the maintenance of glucose homeostasis in vivo. suppresses blood levels by protecting pancreatic β cells from oxidative stress and improving peripheral tissue utilization. To elucidate molecular mechanisms which homeostasis, we generated skeletal muscle (SkM)-specific Keap1 knockout (Keap1MuKO) mice that express abundant their SkM then examined target gene expression tissue. In Keap1MuKO mice, were significantly downregulated glycogen branching...
Abstract Satellite cells, the muscle tissue stem express three Notch receptors (Notch1–3). The function of Notch1 and Notch2 in satellite cells has to date not been fully evaluated. We investigated role myogenic progression adult skeletal using tamoxifen-inducible cell-specific conditional knockout mice for (N1-scKO), (N2-scKO), Notch1/Notch2 (scDKO). In quiescent state, number was slightly reduced N2-scKO, but significantly N1-scKO, almost completely depleted scDKO mice. N1-scKO N2-scKO...
We have identified the amphibian ghrelin from stomach of bullfrog. also examined growth hormone (GH)-releasing activity this novel peptide in both rat and The three forms identified, each comprised 27 or 28 amino acids, possessed 29% sequence identity to mammalian ghrelins. A unique threonine at acid position 3 (Thr(3)) bullfrog differs serine present ghrelins; Thr(3) is acylated by either n-octanoic n-decanoic acid. frog ghrelin-28 has a complete structure GLT...
Although it is accepted that pemphigus antibody binding to keratinocytes (KCs) evokes an array of intracellular biochemical events resulting in cell detachment and death, the triggering remain obscure. It has been postulated vulgaris IgG (PVIgG) KCs induces “desmosomal” signaling. Because contrast integrins classical cadherins, desmoglein (Dsg) molecules are not known elicit signaling, because PV patients also produce non-Dsg autoantibodies, we investigated roles both Dsg non-desmoglein...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular control of membrane properties during temperature acclimation. Membrane fluidity regulation fatty acid desaturase action?Reiko Kasai, Yasuo Kitajima, Charles E. Martin, Yoshinori Nozawa, Lars Skriver, and Guy A. Thompson, Jr.Cite this: Biochemistry 1976, 15, 24, 5228–5233Publication Date (Print):November 1, 1976Publication History Published online1 May 2002Published inissue 1 November...
Adult muscle stem cells (satellite cells) are required for adult skeletal regeneration. A proper balance between quiescence, proliferation, and differentiation is essential the maintenance of satellite cell pool their regenerative function. Although ubiquitin-proteasome most protein degradation in mammalian cells, how its dysfunction affects tissue remains unclear. Here, we investigated function proteasome using mice lacking crucial proteasomal component, Rpt3. Ablation Rpt3 decreased...
The characteristic structure of motor neurons (MNs), particularly the long axons, becomes damaged in early stages amyotrophic lateral sclerosis (ALS). However, molecular pathophysiology axonal degeneration remains to be fully elucidated.Two sets isogenic human-induced pluripotent stem cell (hiPSCs)-derived MNs possessing single amino acid difference (p.H517D) fused sarcoma (FUS) were constructed. By combining MN reporter lentivirus, specific phenotype was analyzed. Moreover, RNA profiling...