A5090549024- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Platelet Disorders and Treatments
- Dermatology and Skin Diseases
- Skin and Cellular Biology Research
- Eosinophilic Disorders and Syndromes
- Monoclonal and Polyclonal Antibodies Research
- Nail Diseases and Treatments
- Autoimmune and Inflammatory Disorders
- Cutaneous lymphoproliferative disorders research
- Psoriasis: Treatment and Pathogenesis
- Dermatological and Skeletal Disorders
- Mast cells and histamine
- Celiac Disease Research and Management
- Cancer Immunotherapy and Biomarkers
- Toxin Mechanisms and Immunotoxins
- Heat shock proteins research
- Contact Dermatitis and Allergies
- Oral and gingival health research
- Drug-Induced Adverse Reactions
- Hair Growth and Disorders
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Cutaneous Melanoma Detection and Management
University of Lübeck
2015-2024
Liechtenstein Institute
2023
John Wiley & Sons (United States)
2023
John Wiley & Sons (United Kingdom)
2023
Hudson Institute
2023
Euroimmun Medizinische Labordiagnostika (Germany)
2023
Oxfam
2023
University Hospital Schleswig-Holstein
2011-2022
Universitäts Hautklinik Kiel
2022
Martin Luther University Halle-Wittenberg
2022
Anti-p200 pemphigoid has been characterized by autoantibodies to an unidentified 200-kDa protein (p200) of the dermal−epidermal junction. The objective this study was identify p200. We performed 2D gel electrophoresis dermal extracts and immunoblotting with patients' sera, followed MS analysis a unique band. band corresponded laminin γ1. Anti-laminin γ1 mAb reacted anti-p200 immunoprecipitates immunoblotting. Sera from 32 patients showed 90% reactivity recombinant products None healthy...
Bullous pemphigoid (BP) is a subepidermal blistering autoimmune disease characterized by autoantibodies against two structural proteins of the epidermal basal membrane zone (BMZ), BP180 (type XVII collagen) and BP230. Patients are usually old suffer from severe pruritus. Advanced age pruritus have been hypothesized as potential risk factors for development in BP.To prospectively determine anti-BMZ antibodies sera patients with advanced and/or compared regular blood donors.Sera (i) chronic...
Abstract UV radiation (UVR) induces serious structural and functional alterations in human skin leading to aging carcinogenesis. Reactive oxygen species are key players UVR‐mediated photodamage induce the DNA‐base‐oxidized, intermediate 8‐hydroxy‐2'‐deoxyguanosine (8‐OHdG). Herein, we report protective action of melatonin against UVR‐induced 8‐OHdG formation depletion antioxidative enzymes using ex vivo full‐thickness exposed UVR a dose (0, 100, 300 mJ/cm 2 )‐ time‐dependent manner 24, 48 hr...
Bullous pemphigoid is the most common autoimmune subepidermal blistering disease of skin and mucous membranes. This typically affects elderly presents with itch localized or generalized bullous lesions. In up to 20% affected patients, bullae may be completely absent, only excoriations, prurigo‐like lesions, eczematous urticated lesions and/or infiltrated plaques are observed. The significantly associated neurological disorders. morbidity its impact on quality life significant. So far, a...
Summary Background: Only limited epidemiologic data are available on autoimmune bullous diseases. Improved diagnostic tools should have led to an increased incidence. To test this hypothesis, all patients with disorders who were treated in the Department of Dermatology at University Würzburg, Germany, between January 2001 and June 2002 analysed prospectively. Patients Methods: Epidemiologic diagnosed disease during time period registered statistically evaluated. Diagnosis was based clinical...
Abstract Background Pemphigus encompasses a group of life‐threatening autoimmune bullous diseases characterized by blisters and erosions the mucous membranes skin. Before era immunosuppressive treatment, prognosis pemphigus was almost fatal. Due to its rarity, only few prospective controlled therapeutic trials are available. Objectives For this reason, European dermatologists with long‐standing interest expertise in basic clinical research has sought define diagnostic guidelines for...
Pemphigus encompasses a group of life-threatening autoimmune bullous diseases characterized by blisters and erosions the mucous membranes skin. Before era immunosuppressive treatment, pemphigus was almost always fatal. Due to its rarity, only few randomized controlled therapeutic trials are available. Recently, rituximab has been approved as first-line treatment for moderate severe vulgaris in Europe United States.The Autoimmune blistering Task Force European Academy Dermatology Venereology...
Abstract Background Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of skin and mucous membranes. This typically affects elderly presents with itch localized or, frequently, generalized bullous lesions. A subset patients only develops excoriations, prurigo‐like lesions, eczematous and/or urticarial erythematous The disease, which significantly associated neurological disorders, has high morbidity severely impacts quality life. Objectives methodology...
This guideline has been initiated by the task force Autoimmune Blistering Diseases of European Academy Dermatology and Venereology, including physicians from all relevant disciplines patient organizations. It is a S3 consensus-based that systematically reviewed literature on mucous membrane pemphigoid (MMP) in MEDLINE EMBASE databases until June 2019, with no limitations language. While first part this addressed methodology, as well epidemiology, terminology, aetiology, clinical presentation...
Abstract This guideline on mucous membrane pemphigoid (MMP) has been elaborated by the Task Force for Autoimmune Blistering Diseases of European Academy Dermatology and Venereology (EADV) with a contribution physicians from all relevant disciplines patient organizations. It is S3 consensus‐based encompassing systematic review literature until June 2019 in MEDLINE EMBASE databases. first part covers methodology, clinical definition MMP, epidemiology, MMP subtypes, immunopathological...
To investigate the possible correlation of levels circulating anti-BP180 autoantibodies with disease activity in bullous pemphigoid (BP).Diagnostic study.Regional referral center at a university dermatology department.Fifteen patients typical clinical, histologic, and immunofluorescence findings BP who had not received prior systemic treatment.Initially, 6 consecutive were treated oral doxycycline niacinamide. Subsequently, 9 combination dapsone prednisolone.Disease activity, serum to BP180,...