A5078552585- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Skin and Cellular Biology Research
- Platelet Disorders and Treatments
- Nail Diseases and Treatments
- Dermatology and Skin Diseases
- Skin Diseases and Diabetes
- Autoimmune and Inflammatory Disorders
- Cutaneous lymphoproliferative disorders research
- Medicine and Dermatology Studies History
- Dermatologic Treatments and Research
- Eosinophilic Disorders and Syndromes
- Dermatological and Skeletal Disorders
- Hair Growth and Disorders
- Inflammatory Myopathies and Dermatomyositis
- Cancer and Skin Lesions
- Cell Adhesion Molecules Research
- Oral Health Pathology and Treatment
- Nonmelanoma Skin Cancer Studies
- Oral and gingival health research
- Blood groups and transfusion
- Genetic and rare skin diseases.
- Psoriasis: Treatment and Pathogenesis
- Wnt/β-catenin signaling in development and cancer
University Hospital of Bern
2016-2025
University of Bern
2016-2025
Foundation for International Environmental Law and Development
2024
Medical University of Vienna
2010-2018
University of California, San Diego
2016
Université de Rouen Normandie
2014
Dermatologie Freiburg
2012
Hôpital Beau-Séjour
1998-2010
University Hospital of Geneva
1999-2008
University of Geneva
1998-2008
Bullous pemphigoid is the most common autoimmune subepidermal blistering disease of skin and mucous membranes. This typically affects elderly presents with itch localized or generalized bullous lesions. In up to 20% affected patients, bullae may be completely absent, only excoriations, prurigo‐like lesions, eczematous urticated lesions and/or infiltrated plaques are observed. The significantly associated neurological disorders. morbidity its impact on quality life significant. So far, a...
Abstract Background Pemphigus encompasses a group of life‐threatening autoimmune bullous diseases characterized by blisters and erosions the mucous membranes skin. Before era immunosuppressive treatment, prognosis pemphigus was almost fatal. Due to its rarity, only few prospective controlled therapeutic trials are available. Objectives For this reason, European dermatologists with long‐standing interest expertise in basic clinical research has sought define diagnostic guidelines for...
Pemphigus encompasses a group of life-threatening autoimmune bullous diseases characterized by blisters and erosions the mucous membranes skin. Before era immunosuppressive treatment, pemphigus was almost always fatal. Due to its rarity, only few randomized controlled therapeutic trials are available. Recently, rituximab has been approved as first-line treatment for moderate severe vulgaris in Europe United States.The Autoimmune blistering Task Force European Academy Dermatology Venereology...
B-cell-depleting therapies increase the risk of morbidity and mortality due to COVID-19. Evidence-based SARS-CoV-2 vaccination strategies for patients on are scarce. We aimed investigate humoral cell-mediated immune responses mRNA-based vaccines in receiving CD20-targeted agents autoimmune disease, malignancy, or transplantation.The RituxiVac study was an investigator-initiated, single-centre, open-label done at Bern University Hospital (Bern, Switzerland). Patients with a treatment history...
Abstract Background Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of skin and mucous membranes. This typically affects elderly presents with itch localized or, frequently, generalized bullous lesions. A subset patients only develops excoriations, prurigo‐like lesions, eczematous and/or urticarial erythematous The disease, which significantly associated neurological disorders, has high morbidity severely impacts quality life. Objectives methodology...
This guideline has been initiated by the task force Autoimmune Blistering Diseases of European Academy Dermatology and Venereology, including physicians from all relevant disciplines patient organizations. It is a S3 consensus-based that systematically reviewed literature on mucous membrane pemphigoid (MMP) in MEDLINE EMBASE databases until June 2019, with no limitations language. While first part this addressed methodology, as well epidemiology, terminology, aetiology, clinical presentation...
Abstract This guideline on mucous membrane pemphigoid (MMP) has been elaborated by the Task Force for Autoimmune Blistering Diseases of European Academy Dermatology and Venereology (EADV) with a contribution physicians from all relevant disciplines patient organizations. It is S3 consensus‐based encompassing systematic review literature until June 2019 in MEDLINE EMBASE databases. first part covers methodology, clinical definition MMP, epidemiology, MMP subtypes, immunopathological...
Bullous pemphigoid (BP), pemphigus vulgaris (PV) and foliaceus (PF) are autoimmune bullous diseases characterized by the presence of tissue-bound circulating autoantibodies directed against disease-specific target antigens skin. Although rare, these run a chronic course associated with significant morbidity mortality. There few prospective data on gender- age-specific incidence disorders.Our aims were: (i) to evaluate BP PV/PF in Swiss patients, as primary endpoint; (ii) assess profile...
Antibodies against the extracellular domain of bullous pemphigoid antigen 2 (BPAG2) are thought to play a key role in pathogenesis (BP), most frequent autoimmune disease skin. Autoreactive T cell responses BPAG2 were investigated 16 BP patients and 24 healthy controls by coculture PBMC with two recombinant proteins (extracellular BPAG2). Primary vitro observed 10/12 expressing BP-associated HLA-DQB1*0301 allele 8/10 DQB1*0301 positive individuals. also restricted three autoreactive lines...
Hemidesmosomes (HDs) are multi-protein complexes that promote stable adhesion of epithelial cells to the underlying extracellular matrix. We assessed interactions between different hemidesmosomal components with each other, mapped binding sites and studied importance these for HD assembly in yeast two-hybrid cell-transfection assays. The results show that: (1) bullous pemphigoid antigen (BP) 180 binds not only BP230, but also plectin. proteins facilitated by Y subdomain N-terminal plakin...
The transcription factor PPAR-γ plays a vital role in the generation of IL-9–producing T H cells.