A5014368565- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Platelet Disorders and Treatments
- Hair Growth and Disorders
- Dermatology and Skin Diseases
- Nail Diseases and Treatments
- Skin and Cellular Biology Research
- melanin and skin pigmentation
- Cutaneous lymphoproliferative disorders research
- Dermatologic Treatments and Research
- Drug-Induced Adverse Reactions
- Oral and gingival health research
- Oral Health Pathology and Treatment
- Nonmelanoma Skin Cancer Studies
- Cancer and Skin Lesions
- Skin Diseases and Diabetes
- Dermatological and Skeletal Disorders
- Genetic and rare skin diseases.
- Autoimmune and Inflammatory Disorders
- Cutaneous Melanoma Detection and Management
- Psoriasis: Treatment and Pathogenesis
- Acne and Rosacea Treatments and Effects
- Eosinophilic Disorders and Syndromes
- Genital Health and Disease
Tehran University of Medical Sciences
2016-2025
Razi Hospital
2016-2025
Papageorgiou General Hospital
2022
Creative Commons
2022
Palo Alto Institute
2022
University of California, San Francisco
2022
Medical University of Sofia
2022
University of Tehran
2005-2022
Imam Khomeini Hospital
2021
Dermatology Research Center
2020
Pemphigus encompasses a group of life-threatening autoimmune bullous diseases characterized by blisters and erosions the mucous membranes skin. Before era immunosuppressive treatment, pemphigus was almost always fatal. Due to its rarity, only few randomized controlled therapeutic trials are available. Recently, rituximab has been approved as first-line treatment for moderate severe vulgaris in Europe United States.The Autoimmune blistering Task Force European Academy Dermatology Venereology...
Abstract Background Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of skin and mucous membranes. This typically affects elderly presents with itch localized or, frequently, generalized bullous lesions. A subset patients only develops excoriations, prurigo‐like lesions, eczematous and/or urticarial erythematous The disease, which significantly associated neurological disorders, has high morbidity severely impacts quality life. Objectives methodology...
Pemphigus is a rare and chronic life-threatening disease. The clinical picture varies in reports from different regions of the world.To define forms pemphigus large cohort patients.Prospective analysis 1209 patients diagnosed followed at Research Unit, Tehran University for Medical Sciences, 1984 to 2003.The mean age onset was 42 years with female male ratio 1.5/1. most frequent form vulgaris. In vulgaris, patients' mucous membrane involvement alone observed 18%, skin 12%, both 70%....
Abstract Background Paraneoplastic pemphigus (PNP), also called paraneoplastic autoimmune multiorgan syndrome (PAMS), is a rare disease with mucocutaneous and multi‐organ involvement. PNP/PAMS typically associated lymphoproliferative or haematological malignancies, less frequently solid malignancies. The mortality rate of elevated owing to the increased risk severe infections disease‐associated complications, such as bronchiolitis obliterans. Objectives These guidelines summarize...
Abstract Pemphigus vulgaris with painful chronic blisters and/or erosions on skin and mucosa can impair quality of life (QOL). Therapeutic modalities in the long run have additional negative impact. There are few studies that focused QOL such patients except treated cases. The aim this study was to describe effect disease per se before receiving treatment evaluation psychological status its their QOL. A total 61 newly diagnosed non‐treated pemphigus participated study. Persian version...
Epidermolysis bullosa acquisita (EBA) is a complex autoimmune bullous disease with variable clinical presentations and multiple possible diagnostic tests, making an international consensus on the diagnosis of EBA essential. To obtain criteria for EBA. The International Bullous Diseases Group (IBDG) met three times to discuss For final voting exercise, 22 experts from 14 different countries voted 50 items. When > 30% disagreed proposal, discussion was held re‐voting carried out. In total, 48...
Lichen planopilaris (LPP) is an immune-mediated cicatricial alopecia. The main clinical presentations of LPP include classic form, frontal fibrosing alopecia (FFA), and Graham-Little-Piccardi-Lassueur syndrome (GLPLS). We reviewed medical records all 291 patients diagnosied with from 2006 to 2017 in Department Dermatology, Tehran University Medical Sciences. was more common women than men. planus (LP) seen 59 (20.3%). Parietal lesions (69.75%), (27.14%), occipital (23.71%), temporal (21.64%)...
Abstract Background Pruritus is one of the most bothersome symptoms in patients on maintenance hemodialysis (HD), however little progress seen our understanding its pathogenesis. The aim this study was to evaluate frequency pruritus HD Tehran, Iran, and correlate presence intensity with relevant clinical laboratory parameters. Methods One hundred sixty-seven at three out-patient units were enrolled study. Itch scored as mild, moderate severe. Some parameters (age, sex, xerosis, neuropathy,...
Our objective was to study tongue lesions and their significance in psoriatic patients.The oral mucosa examined 200 patients presenting Razi Hospital Tehran, Iran, matched controls.Fissured (FT) benign migratory glossitis (BMG) were the two most frequent findings. FT seen more frequently (n = 66, 33%) than control group 19, 9.5%) [odds ratio (OR): 4.69; 95% confidence interval (CI): 2.61-8.52] (p-value < 0.0001). BMG, too, significantly (28 cases, 14%) (12 6%) (OR: 2.55; CI: 1.20-5.50)...
Abstract Background Vitiligo is an acquired depigmenting disorder due to destruction of melanocytes. Although many theories have been suggested for its pathogenesis, the role autoimmunity most popular one. The association vitiligo with autoimmune thyroid diseases and increased prevalence autoantibodies including in favor this role. Our objective was compare frequency peroxidase antibody (anti-TPO) patients healthy subjects Iran. Methods Ninety-four cases (46 female 48 male) 96 control (49 47...
Down syndrome is the most common chromosomal abnormality affecting numerous organs, including skin. Our aim was to study mucocutaneous findings in this syndrome. To do so, 100 children with attending Schools for Children Special Educational Needs and centers affiliated Welfare Rehabilitation Organization two provinces of Iran were thoroughly examined skin mucosal lesions. Their mean age 11.2 years (3-20 years). Mucocutaneous noted 61. These as follows (in decreasing order)--fissured tongue...
Abstract Background Pemphigus vulgaris (PV) is a chronic autoimmune blistering disorder of the skin and mucosa characterized by presence autoantibodies against desmoglein3 (Dsg3). Some patients also have antibodies desmoglein1 (Dsg1). The aims this study were to evaluate diagnostic value Dsg enzyme‐linked immunosorbent assay (ELISA) in Iranian PV patients, assess its correlation with clinical phenotype severity disease investigate changes these after treatment. Methods Seventy‐three (29 men,...
The classic treatment for pemphigus vulgaris is prednisolone. Immunosuppressive drugs can be used in association.To compare the efficacy of Azathioprine reducing Disease Activity Index (DAI).A double blind randomized controlled study was conducted on 56 new patients, assigned to two therapeutic groups: (i) prednisolone plus placebo; (ii) Azathioprine. Patients were checked regularly 1 year. 'Complete remission' defined as healing all lesions after 12 months, and <7.5 mg daily, (DAI ≤ 1)....
Recently, the clinical pemphigus disease activity indexes of Pemphigus Disease Area Index (PDAI), Autoimmune Bullous Skin Disorder Intensity Score (ABSIS), and Vulgaris Activity (PVAS) were validated to correlate with physician global assessment. The antidesmoglein (anti-Dsg) autoantibodies are known mostly activity. correlation between these anti-Dsg1 anti-Dsg3 enzyme-linked immunosorbent assay values has not been previously evaluated.To evaluate PDAI, ABSIS, PVAS in a large number patients...
Autosomal recessive congenital ichthyosis (ARCI), a phenotypically heterogeneous group of non-syndromic Mendelian disorders keratinization, is caused by mutations in as many 13 distinct genes. We examined cohort 125 consanguineous families with ARCI for underlying genetic mutations. The patients' DNA was analyzed gene-targeted next generation sequencing panel comprising 38 associated interpretations results genomic data were assisted genome-wide homozygosity mapping and transcriptome...
Abstract Background There are limited data on the validity of dermatoscopy in primary cicatricial alopecias ( PCA s) and its subtypes, including lichen planopilaris discoid lupus erythematosus. Trichoscopic features s, their prevalence, were evaluated this study. Methods One hundred patients with underwent dermatoscopy. Biopsy specimens obtained after site was marked a dermatoscope. The control group comprised 100 non‐cicatricial alopecia normal individuals. Finally, sensitivity, specificity...
Abstract Background The International Dermoscopy Society (IDS) recently released a set of five basic dermoscopic parameters (vessels, scales, follicular findings, “other structures,” and specific clues) encompassing total 31 subitems to standardize the use dermoscopy in non‐neoplastic dermatoses, yet they have been developed taking into account Caucasian/Asian skin, with consequent possible limitations if used dark skin. Objectives To validate abovementioned criteria for dark‐skinned...
Abstract Background Acne scar is an inflammatory condition, which commonly occurs in patients with acne vulgaris, especially adults. Mesogels have been reported effective improving atrophic scars. Aims We investigated the efficacy of adding Profhilo (a hyaluronic acid‐based filler) to subcision as a new treatment method. Methods Twelve aged 18–45 years scars on both sides face participated this single‐blinded, split‐face, randomized controlled trial. Each side was randomly assigned one...