A5059337810- Autoimmune Bullous Skin Diseases
- Nicotinic Acetylcholine Receptors Study
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Receptor Mechanisms and Signaling
- Platelet Disorders and Treatments
- Synthesis and Biological Evaluation
- Ion channel regulation and function
- Cholinesterase and Neurodegenerative Diseases
- Toxin Mechanisms and Immunotoxins
- Vagus Nerve Stimulation Research
- Monoclonal and Polyclonal Antibodies Research
- Nail Diseases and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Dermatology and Skin Diseases
- bioluminescence and chemiluminescence research
- Skin and Cellular Biology Research
- Dermatologic Treatments and Research
- Olfactory and Sensory Function Studies
- Urinary Bladder and Prostate Research
- Neuroscience and Neuropharmacology Research
- Insect and Pesticide Research
- Hair Growth and Disorders
- Antimicrobial Peptides and Activities
- Eosinophilic Disorders and Syndromes
University of California, Irvine
2016-2025
UC Irvine Health
2017
University of California, Irvine Medical Center
2015
Matrix Research (United States)
2015
University of California System
2012
In-Q-Tel
2011
University of California, Davis
1998-2007
University of California Davis Medical Center
2000-2006
University of Lübeck
2006
University of Minnesota
1993-1994
The use of tobacco products is associated with an increased incidence periodontal disease, poor response to therapy, and a high risk for developing head neck cancer. Nicotine tobacco-derived nitrosamines have been shown exhibit their pathobiologic effects due in part activation the nicotinic acetylcholine (ACh) receptors (nAChRs), mainly alpha7 nAChR, expressed by oral keratinocytes (KCs). This study was designed gain mechanistic insight into alpha7-mediated morbidity cavity. We investigated...
Abstract The importance of acetylcholine as a neurotransmitter in the nervous system is well established, but little yet known about its recently described role an autocrine and paracrine hormone wide variety nonneuronal cells. Consistent with expression normal lung, small cell lung carcinoma (SCLC) synthesize secrete acetylcholine, which acts growth factor through both nicotinic muscarinic cholinergic mechanisms. purpose this study was to determine if interruption signaling has potential...
Several ganglionic nicotinic acetylcholine receptor (nAChR) types are abundantly expressed in nonneuronal locations, but their functions remain unknown. We found that keratinocyte α7 nAChR controls homeostasis and terminal differentiation of epidermal keratinocytes required for formation the skin barrier. The effects functional inactivation on cell cycle progression, differentiation, apoptosis were studied monolayers treated with α-bungarotoxin or antisense oligonucleotides Acra7 homozygous...
Although it is accepted that pemphigus antibody binding to keratinocytes (KCs) evokes an array of intracellular biochemical events resulting in cell detachment and death, the triggering remain obscure. It has been postulated vulgaris IgG (PVIgG) KCs induces “desmosomal” signaling. Because contrast integrins classical cadherins, desmoglein (Dsg) molecules are not known elicit signaling, because PV patients also produce non-Dsg autoantibodies, we investigated roles both Dsg non-desmoglein...
Understanding the acantholytic pathways leading to blistering in pemphigus vulgaris (PV) is a key development of novel treatments. A paradigm keratinocyte damage PV, termed apoptolysis, links suprabasal and cell death basal shrinkage rendering 'tombstone' appearance PV lesions. In contrast classic apoptosis mediating toxic epidermal necrolysis causes subsequent sloughing entire epidermis. Apoptolysis includes five consecutive steps. (1) Binding autoantibodies antigens. (2) Activation EGF...
AbstractFrequent users of smokeless tobacco (ST) have an increased risk for developing oral cancer. Nicotine and its derivatives may contribute to tumorigenesis through stimulation nicotinic acetylcholine (nAChRs) in target cells. Emerging evidence indicates that nAChRs can be stimulated by the nicotine-derived nitrosamines 4-(methylnitrosamino)-1-(3–pyridyl)-1-butanone (NNK) N'-nitrosonornicotine (NNN) induce cavity tumors laboratory animals. This study was designed elucidate...