A5069773833- Nicotinic Acetylcholine Receptors Study
- Bone Tissue Engineering Materials
- Receptor Mechanisms and Signaling
- Orthopaedic implants and arthroplasty
- Ion channel regulation and function
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Bone health and treatments
- Bone fractures and treatments
- Orthopedic Infections and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Urinary Bladder and Prostate Research
- Vagus Nerve Stimulation Research
- Neuropeptides and Animal Physiology
- Magnesium Alloys: Properties and Applications
- Nerve injury and regeneration
- Vitamin D Research Studies
- Hip and Femur Fractures
- Neuroscience of respiration and sleep
- Total Knee Arthroplasty Outcomes
- Osteoarthritis Treatment and Mechanisms
- Drug Transport and Resistance Mechanisms
- Nanoparticles: synthesis and applications
- Biochemical Analysis and Sensing Techniques
University of Giessen
2014-2023
University of Bremen
2017
Karger Publishers (Switzerland)
2013
Universitätsklinikum Gießen und Marburg
2009-2011
Giessen School of Theology
2010
Institute of Pathology Celle
2006
Board of the Swiss Federal Institutes of Technology
2004
ETH Zurich
2004
Heinrich Heine University Düsseldorf
1995-1997
In airway epithelia, non-neuronal cholinergic regulations have been described; however, the route for acetylcholine (ACh) release has not verified. To investigate whether organic cation transporters (OCTs) serve this function, we studied expression of OCTs in epithelia and their capability to translocate ACh. Using immunohistochemistry rats humans, OCT1, OCT2, OCT3 were localized luminal membrane ciliated epithelial cells. OCT2 showed strongest membrane. We expressed OCT isoforms oocytes...
The first objective was to investigate new bone formation in a critical-size metaphyseal defect the femur of ovariectomized rats filled with strontium modified calcium phosphate cement (SrCPC) compared (CPC) and empty defects. Second, detection release from materials as well collagen mass distribution fracture should be targeted by time flight secondary ion spectrometry (TOF-SIMS). 45 female Sprague-Dawley were randomly assigned three different treatment groups: (1) SrCPC (n = 15), (2) CPC...
Several ganglionic nicotinic acetylcholine receptor (nAChR) types are abundantly expressed in nonneuronal locations, but their functions remain unknown. We found that keratinocyte α7 nAChR controls homeostasis and terminal differentiation of epidermal keratinocytes required for formation the skin barrier. The effects functional inactivation on cell cycle progression, differentiation, apoptosis were studied monolayers treated with α-bungarotoxin or antisense oligonucleotides Acra7 homozygous...
Screws for ligament reconstruction are nowadays mostly made of poly-L-lactide (PLLA). However, magnesium-based biomaterials gathering increased interest in this research field because their good mechanical property and osteoanabolic influence on bone metabolism. The aim pilot study was to evaluate the biocompatibility an interference screw magnesium alloy W4 by diecasting milling using different PEO-coatings with calcium phosphates. PLLA titanium screws were used as control samples....
Use of magnesium for resorbable metal implants is a new concept in orthopaedic and dental medicine. The majority studies on magnesium's biocompatibility vitro have assessed the short-term effect extract cells. aim this study was to evaluate influence direct exposure alloys bioactivity primary human reaming debris-derived (HRD) cells.Pure Mg, Mg2Ag, WE43 Mg10Gd were tested biocompatibility. consisted assessment cell viability by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide...
It has been proposed that serotonin (5-HT)-mediated constriction of the murine trachea is largely dependent on acetylcholine (ACh) released from epithelium. We recently demonstrated ACh can be non-neuronal cells by corticosteroid-sensitive polyspecific organic cation transporters (OCTs), which are also expressed airway epithelial cells. Hence, hypothesis emerged 5-HT evokes bronchoconstriction inducing release via OCTs.We tested this analysing in precision-cut lung slices using OCT and...
Background:As women are the population most affected by multifactorial osteoporosis, research is focused on unraveling underlying mechanism of osteoporosis induction in rats combining ovariectomy (OVX) either with calcium, phosphorus, vitamin C and D2/D3 deficiency, or administration glucocorticoid (dexamethasone).Material/Methods:Different skeletal sites sham, OVX-Diet OVX-Steroid were analyzed Dual Energy X-ray Absorptiometry (DEXA) at varied time points 0, 4 12 weeks to determine compare...
Staphylococcus aureus is the principle causative pathogen of osteomyelitis and implant-associated bone infections. It able to invade proliferate inside osteoblasts thus avoiding antibiotic therapy host immune system. Therefore, development alternative approaches stimulate innate responses could be beneficial in prophylaxis against S. infection. TLR9 intracellular receptor which recognizes unmethylated bacterial CpG-DNA activates cells. Synthetic CpG-motifs containing oligodeoxynucleotide...