A5026069428- Immune Response and Inflammation
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Asthma and respiratory diseases
- Microbial infections and disease research
- Pediatric health and respiratory diseases
- Cell Adhesion Molecules Research
- Animal health and immunology
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Animal Virus Infections Studies
- Neuropeptides and Animal Physiology
- IL-33, ST2, and ILC Pathways
- Mast cells and histamine
- Animal Diversity and Health Studies
- Stress Responses and Cortisol
- Respiratory viral infections research
- Receptor Mechanisms and Signaling
- Neuroscience of respiration and sleep
- Pneumonia and Respiratory Infections
- Allergic Rhinitis and Sensitization
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- Immunotoxicology and immune responses
Medizinische Hochschule Hannover
2009-2021
National Institute of Economic Research
2020
John Wiley & Sons (United States)
2020
Hudson Institute
2020
Saarland University
2016
University of Saskatchewan
2005
Universitätsklinik für Kinder und Jugendpsychiatrie
2004
University of Zurich
2003
Kiel University
2001
University of California, San Francisco
2000
Huntington's disease (HD) is a late manifesting neurodegenerative disorder in humans caused by an expansion of CAG trinucleotide repeat more than 39 units gene unknown function. Several mouse models have been reported which show rapid progression phenotype leading to death within 3–5 months (transgenic models) resembling the rare juvenile course HD (Westphal variant) or do not present with any symptoms (knock-in mice). Owing small size brain, mice are suitable for repetitive vivo imaging...
In the respiratory tract, lymphoid aggregates with a specialized epithelium have been called bronchus-associated tissue (BALT) and compared to organized of gut (GALT), e.g., Peyer's patches. BALT might play central role in antigen uptake, initiating immune responses disseminating primed cells tract. present study, lungs mice, rats, guinea pigs, rabbits, cats, humans studied respect presence number dependence on age microbial stimulation. is not constitutive structure all these species. Its...
Abstract Prophylactic tumor vaccination against subsequent challenge depends on effective cross‐priming in vivo . Professional APCs process antigens from whole cells and present them to CD4 + CD8 T cells. Data suggest that dendritic more efficiently necrotic than apoptotic vitro We compared the effect of apoptosis vs. necrosis using different models (CT26, RENCA, B16 CT26‐HA). Apoptosis was induced by γ‐irradiation prior injection verified Apoptotic CT26‐HA, CT26‐wt or RENCA prevented...
Abstract In comparison to secondary lymphoid organs, gut‐associated tissues such as isolated follicles (ILF) and cryptopatches (CP) have been less intensively studied. To gain a better insight into processes regulating organization function of these structures, which are believed participate in immune responses extrathymic T cell development, we characterized the structures murine small intestine more detail. The size cellular composition intestinal aggregations were analyzed C57BL/6 BALB/c...
In mucosal immunology nasal-associated lymphoid tissue (NALT) is taken as a constitutive structure of the nasal immune system and target in strategies local defence an induction site for vaccination. These concepts are based on findings rodents, but it has not been investigated systematically whether NALT also present humans if so which amount localization. postmortem study presence documented morphologically distinct additional to structures Waldeyer's ring. Human blocks 150 children who...
Recent clinical studies have highlighted that female sex hormones represent potential neuroprotective mediators against damage caused by acute and chronic brain diseases. This evidence has been confirmed experimental documenting the protective role of both in vitro vivo, although these did not specifically focus on Huntington's disease (HD). We therefore investigated onset course HD male transgenic (tg) (CAGn51) control rats across age focused three aspects: (i) behavioral physiological...