A5102759030- Algebraic Geometry and Number Theory
- Advanced Algebra and Geometry
- Geometry and complex manifolds
- Geometric and Algebraic Topology
- Geometric Analysis and Curvature Flows
- Commutative Algebra and Its Applications
- Polynomial and algebraic computation
- Homotopy and Cohomology in Algebraic Topology
- Advanced Differential Equations and Dynamical Systems
- Cystic Fibrosis Research Advances
- Advanced Numerical Analysis Techniques
- Finite Group Theory Research
- Genetic Neurodegenerative Diseases
- Algebraic structures and combinatorial models
- Mathematics and Applications
- Analytic Number Theory Research
- Head and Neck Cancer Studies
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Markov Chains and Monte Carlo Methods
- Advanced Optimization Algorithms Research
- Point processes and geometric inequalities
- Mitochondrial Function and Pathology
- Viral-associated cancers and disorders
- Genomics, phytochemicals, and oxidative stress
University of Bayreuth
2011-2021
University of Rostock
1994-2019
University of Warwick
2012
Scuola Normale Superiore
2012
Schmerzklinik Kiel
2010
University of Lübeck
2004
University Hospital Schleswig-Holstein
2004
University of Göttingen
1989-2000
West Los Angeles College
1998
Ludwig Boltzmann Gesellschaft
1997
Huntington's disease (HD) is a late manifesting neurodegenerative disorder in humans caused by an expansion of CAG trinucleotide repeat more than 39 units gene unknown function. Several mouse models have been reported which show rapid progression phenotype leading to death within 3–5 months (transgenic models) resembling the rare juvenile course HD (Westphal variant) or do not present with any symptoms (knock-in mice). Owing small size brain, mice are suitable for repetitive vivo imaging...
Abstract Autosomal dominant spinocerebellar ataxias (SCAs) are a group of neurodegenerative disorders clinically characterized by late‐onset ataxia and variable other manifestations. Genetically clinically, SCA is highly heterogeneous. Recently, CAG repeat expansions in the gene encoding TATA‐binding protein (TBP) have been found new form SCA, which has designated SCA17. To estimate frequency SCA17 among white patients to define phenotypic variability, we determined large sample 1,318...
We classify all the surfaces with p g = q 0 which admit an unramified covering isomorphic to a product of curves.Beyond trivial case P 1 × we find 17 families explicitly describe.We reduce problem combinatorial description certain generating systems for finite groups solve using also MAGMA's library small order.
We construct many new surfaces of general type with $q=p_g = 0$ whose canonical model is the quotient product two curves by action a finite group $G$, constructing in this way interesting fundamental groups which distinguish connected components moduli space type. indeed classify all such singular (the smooth case was classified an earlier work). As important tool we prove structure theorem giving precise description quotients products $G$.
Dystonia is a clinically and genetically heterogeneous movement disorder characterized by sustained muscle contractions affecting one or more sites of the body, frequently causing twisting repetitive movements abnormal postures. A 3-base pair (GAG) deletion in DYT1 gene held responsible for most cases early-onset primary generalized dystonia Ashkenazi Jewish population as well non-Jewish patients.To investigate prevalence GAG phenotypic variability general testing patients with different...
Nonintegrated, circular DNA molecules of Herpesvirus saimiri and ateles were found in five lymphoid cell lines originating from tumor tissues or established by vitro immortalization T lymphocytes. The arrangement unique (L) repetitive (H) sequences viral genomes was analyzed partial denaturation mapping followed visualization with an electron microscope. Three types structures found. (i) virus-producing line RLC, which is derived H. ateles-induced rabbit lymphoma, contains consist a single...
A product-quotient surface is the minimal resolution of singularities quotient a product two curves by action finite group acting separately on factors. We classify all surfaces general type with geometric genus 0: they form 72 families. show that there exactly one whose canonical class has positive selfintersection which not minimal, and describe its <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="left-parenthesis negative 1...
Abstract To evaluate the significance of expanded CTG repeats at SCA8 locus, we analyzed allele distribution in 1,262 German ataxia patients. We found intermediate and with similar frequencies patients without established genetic diseases. One family linked to locus showed incomplete penetrance an association smaller more severe disease. Our data question disease‐causing character expansions for advise great caution testing. Ann Neurol 2003;54:110–115
We continue our investigation of the connected components moduli space surfaces general type containing Burniat surfaces, correcting a mistake in part II. define family extended with K_S^2 = 4 , resp. 3, and prove that they are deformation nodal 3. show together K_S^2=4 form component space. K_S^2=3 an irreducible open set Finally we point out interesting pathology given group automorphisms G . In fact, for minimal model S surface (G (\mathbb Z/2 \mathbb Z)^2) have \operatorname{Def}(S,G)...
Combination cancer chemotherapy induced toxicity can be associated with combined pharmacogenetic syndromes. Dihydropyrimidine dehydrogenase (DPD) is the principal enzyme involved in catabolic detoxification of 5-fluorouracil (5FU). A heterozygous G > transition at 5' splicing donor consensus sequence intron 14 leading to exon skipping (IVS14+1 A, DPYD*2A) partial loss activity may partly responsible for 5FU toxicity, whereas irinotecan part explained by an aberrant UGT1A1 promoter (TA)(n)...
Answering a question posed by Enriques, we construct minimal smooth algebraic surface S of general type over the complex numbers with K 2 = 45 and pg 4, birational canonical map. The system |K S| has fixed part degree image is 19. rigid, indeed ball quotient. It obtained as an Abelian covering plane branched arrangement lines already considered Hirzebruch, it first such example which regular (q 0).
The first main purpose of this paper is to contribute the existing knowledge about complex projective surfaces $S$ general type with $p_g(S) = 0$ and their moduli spaces, constructing 19 new families such hitherto unknown fundamental groups. We also provide a table containing all known K^2 <=7. Our second describe in greater generality groups smooth varieties which occur as minimal resolutions quotient product curves by action finite group. classify, two dimensional case, q=p_g 0 obtained...
Using a new description of the surfaces discovered by Keum and later investigated Naie, their fundamental group, we prove following main result. Let S be smooth complex projective surface which is homotopically equivalent to Keum–Naie surface. Then The connected component Gieseker moduli space corresponding irreducible, normal, unirational dimension 6.
In this article we suggest a new approach to the systematic, computer-aided construction and classification of product-quotient surfaces, introducing invariant, integer \gamma , which depends only on singularities quotient model X = (C_1 \times C_2)/G . It turns out that is related codimension subspace H^{1,1} generated by algebraic curves coming from (i.e., classes two fibers Hirzebruch-Jung strings arising minimal resolution ). Profiting insight developed implemented an algorithm in...