A5037161101- Corporate Governance and Management
- Innovation and Knowledge Management
- Peptidase Inhibition and Analysis
- Neuropeptides and Animal Physiology
- Innovation, Technology, and Society
- Business Strategy and Innovation
- Neonatal Respiratory Health Research
- Flexible and Reconfigurable Manufacturing Systems
- Asthma and respiratory diseases
- Digital Innovation in Industries
- Advanced SAR Imaging Techniques
- Stress Responses and Cortisol
- Service and Product Innovation
- Creativity in Education and Neuroscience
- Psychology, Coaching, and Therapy
- Product Development and Customization
- Genetic Neurodegenerative Diseases
- Public Administration and Political Analysis
- Radar Systems and Signal Processing
- Firm Innovation and Growth
- Outsourcing and Supply Chain Management
- Respiratory Support and Mechanisms
- Sociology and Education Studies
- International Business and FDI
- Distributed and Parallel Computing Systems
Medizinische Hochschule Hannover
2014-2025
Philipps University of Marburg
2010-2023
Infineon Technologies (Canada)
2022-2023
Infineon Technologies (Germany)
2019-2022
Friedrich-Alexander-Universität Erlangen-Nürnberg
2010-2022
University Hospital of Bern
2022
Spital Linth
2021
Klinik und Poliklinik für Orthopädie, Physikalische Medizin und Rehabilitation
2020
Deutsches Institut für Normung
2018
Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin
2017
JUQUEEN is a high-scaling supercomputer funded mainly by the Gauss Centre for Supercomputing and Helmholtz Association hosted Jülich Centre. It 28 rack, IBM Blue Gene/Q® system combining 28,672 compute nodes through high-speed network providing an overall peak performance of 5.9 Petaflops.
Recent clinical studies have highlighted that female sex hormones represent potential neuroprotective mediators against damage caused by acute and chronic brain diseases. This evidence has been confirmed experimental documenting the protective role of both in vitro vivo, although these did not specifically focus on Huntington's disease (HD). We therefore investigated onset course HD male transgenic (tg) (CAGn51) control rats across age focused three aspects: (i) behavioral physiological...
Abstract Chemokines mediate the recruitment of leukocytes to sites inflammation. N-terminal truncation chemokines by protease dipeptidyl peptidase IV (DPPIV) potentially restricts their activity during inflammatory processes such as allergic reactions, but direct evidence in vivo is very rare. After demonstrating that chemokine CCL11/eotaxin DPPIV results a loss CCR3-mediated intracellular calcium mobilization and CCR3 internalization human eosinophils, we focused on role CCL11 provide for...
Cellular proliferation, differentiation, integration, and survival within the adult neural stem cell niche are altered under pathological conditions, but molecular cues regulating biology of this mostly unknown. We examined hippocampal in a transgenic rat model Huntington disease. In model, progressive cognitive deficits develop at age 9months, suggesting possible dysfunction. found disease-associated decline progenitor proliferation accompanied by an expansion pool 5-bromo-2-deoxyuridine...
Uncertainty about the optimal respiratory support strategies in critically ill COVID-19 patients is widespread. While risks and benefits of noninvasive techniques versus early invasive mechanical ventilation (IMV) are intensely debated, actual evidence lacking. We sought to assess different strategies, employed intensive care units during first months pandemic on intubation unit (ICU) mortality rates.Subanalysis a prospective, multinational registry patients. Patients were subclassified into...
Huntington's disease (HD) is caused by an expanded CAG repeat leading to the synthesis of aberrant protein and formation polyglutamine (polyQ)-containing inclusions aggregates. Limited information available concerning association neuropathological markers with development behavioral in HD. Using a previously generated transgenic rat model HD (tgHD rat), we performed studies on time-course symptoms (motor function, learning, anxiety) appearance striatal atrophy, 1C2 immunopositive aggregates...
An enzymatic activity has been found in cytosolic preparations from mouse epidermis which catalyzes the formation of 8-hydroperoxyeicosatetraenoic acid/8-hydroxyeicosatetraenoic acid (8-HPETE/8-HETE) arachidonate. In contrast to 12-lipoxygenase this enzyme was not detectable normal (untreated) skin but only after vivo treatment with phorbol ester tumor promoter TPA (12-O-tetradecanoylphorbol-13-acetate). The induction showed a maximum at 24 h strictly depended on age mice and dose prevented...
The expression of dipeptidyl peptidase 4 (DP4, CD26) affects T-cell recruitment to lungs in an experimental rat asthma model. Furthermore, the gene structural homologous DP10 represents a susceptibility locus for humans, and functional DP8/9 are expressed human leukocytes. Thus, although several mechanisms may account role DP4-like peptidases asthma, detailed information on their anatomical sites function is lacking. Therefore, bronchi lung parenchyma were evaluated using...
Significance In Huntington disease (HD) gene carriers the disease-causing mutant Huntingtin (m HTT ) is already present during early developmental stages, but, surprisingly, HD patients develop clinical symptoms only many years later. While a role of has been described, so far new therapeutic approaches targeting those neurodevelopmental processes are lacking. Here, we show that behavioral, cellular, and molecular changes associated with m in postnatal period genetic animal models can be...
12-lipoxygenase-catalyzed arachidonic acid metabolism in normal and neoplastic mouse epidermis was assessed by cDNA cloning of the epidermal 12-lipoxygenases studying their expression patterns, enzyme activities, product levels. Papillomas squamous cell carcinomas induced initiation/promotion protocol contained 50- to 60-fold more 12-hydroxy-5,8,10,14-eicosatetraenoic (HETE) than epidermis. The ratio S R enantiomers 9:1. This indicates that most this eicosanoid enzymatic origin. Accordingly,...
Huntington's disease (HD) is an inherited progressive neurodegenerative disorder caused by expanded CAG repeat in exon 1 of the huntingtin gene (HTT). The primary neuropathology HD has been attributed to preferential degeneration medium spiny neurons (MSN) striatum. Reports on striatal neurogenesis have a subject debate; nevertheless, it should be considered as endogenous attempt repair brain. subventricular zone (SVZ) might offer close-by region supply degenerated striatum with new cells....
We present a radar-based detection processing framework for accurate and counting of human targets in an indoor environment. This can be used to control lighting, heating, ventilation air conditioning (HVAC) smart homes other presence related loads commercial, office, public spaces. Such home applications facilitate monitoring, controlling, saving energy. Conventionally, the radar range-Doppler pipeline includes moving target indicators (MTI) remove static targets, maximal ratio combining...
Anxiety and depression are common in patients with rheumatic diseases, but their impact across conditions like rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), primary Sjögren's disease (SjD) is still not well understood. This study aims to compare depression, anxiety, fatigue, effects on activity physical these conditions. From January 2019 March 2021, RA, SjD SLE were assessed consecutively a monocentric cross-sectional at the rheumatology outpatient clinic of Hannover...
Psychological stress causes phenotypic changes in circulating lymphocytes and is regarded as an important trigger of the Th1-polarized inflammatory skin disease psoriasis.To study effects psychological on immunological parameters, i.e. membrane molecules relevant to pathophysiology psoriasis, especially cutaneous lymphocyte-associated antigens (CLA) involved T natural killer (NK) cells homing skin.The severity psoriasis was assessed patients using Psoriasis Area Severity Index. Patients with...