A5013201631- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- interferon and immune responses
- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autoimmune and Inflammatory Disorders
- Urticaria and Related Conditions
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Mast cells and histamine
- Cutaneous lymphoproliferative disorders research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Autoimmune Bullous Skin Diseases
- Eosinophilic Disorders and Syndromes
- Cancer and Skin Lesions
- RNA modifications and cancer
- Nail Diseases and Treatments
- Immune Response and Inflammation
- Skin and Cellular Biology Research
- Autoimmune and Inflammatory Disorders Research
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
Hyogo University
2022-2025
Wakayama Medical University
2014-2023
Tokyo Metropolitan Institute of Gerontology
2009-2023
Hyogo Medical University
2021-2022
Tokyo Metropolitan Geriatric Hospital
2010-2022
Aino University
2015
Universitätsklinikum Erlangen
2011
Kyoto University
1997-2009
Hokkaido University
2009
Health Sciences University of Hokkaido
2009
Nakajo-Nishimura syndrome (NNS) is a disorder that segregates in an autosomal recessive fashion. Symptoms include periodic fever, skin rash, partial lipomuscular atrophy, and joint contracture. Here, we report mutation the human proteasome subunit beta type 8 gene (PSMB8) encodes immunoproteasome β5i patients with NNS. This G201V disrupts β-sheet structure, protrudes from loop interfaces β4 subunit, close proximity to catalytic threonine residue. The mutant not efficiently incorporated...
Abstract Objective Blau syndrome and its sporadic counterpart, early‐onset sarcoidosis (EOS), share a phenotype featuring the symptom triad of skin rash, arthritis, uveitis. This systemic inflammatory granulomatosis is associated with mutations in NOD2 gene. The aim this study was to describe clinical manifestations syndrome/EOS Japanese patients determine whether genotype basal NF‐κB activity predict phenotype. Methods Twenty were recruited. Mutated categorized based on activity, which...
Age-related sarcopenia constitutes an important health problem associated with adverse outcomes. Sarcopenia is closely fat infiltration in muscle, which attributable to interstitial mesenchymal progenitors. Mesenchymal progenitors are nonmyogenic nature but required for homeostatic muscle maintenance. However, the underlying mechanism of progenitor-dependent maintenance not clear, nor precise role sarcopenia. Here, we show that mice genetically engineered specifically deplete exhibited...
Summary. Type‐I interferons (IFNs) and the interferon‐stimulated genes (ISGs) play a major role in antivirus responses against hepatitis C virus (HCV) infection. In this study, we studied expression profiles of ISGs cells supporting subgenomic HCV replication (Huh7/Rep), screened their activities to suppress replication. Real‐time PCR analyses showed that levels 23 were significantly lower Huh7/Rep than naive Huh7 due transcriptional suppression response element (ISRE). Furthermore, level...
Although frailty and cognitive impairment are critical risk factors for disability mortality in the general population of older inhabitants, prevalence incidence these individuals treated specialty outpatient clinics unknown. We recently established a clinic comprehensive assessments conditions such as frailty, sarcopenia, cognition, planned 3-year prospective observational study to identify progression aging-related statuses. To date, we recruited 323 patients who revealed symptoms...
Abstract Tolerance to self‐antigens expressed in peripheral organs is maintained by CD4 + CD25 Foxp3 Treg cells, which are generated as a result of thymic selection or induction. Here, we demonstrate that steady‐state migratory DCs from the skin mediated conversion draining lymph nodes mice. These displayed partially mature MHC II int CD86 CD40 hi CCR7 phenotype, used endogenous TGF‐β for and showed nuclear RelB translocation. Deficiency alternative NF‐κB signaling pathway (RelB/p52) reduced...
Objectives To collect clinical information and NOD2 mutation data on patients with Blau syndrome to evaluate their prognosis. Methods Fifty mutations were analysed. The activity of each mutant was evaluated in HEK293 cells by reporter assay. Clinical collected from medical records through the attending physicians. Results study population comprised 26 males 24 females aged 0–61 years. Thirty-two cases sporadic, 18 familial 9 unrelated families. Fifteen different identified, including 2 novel...
Abstract Background Monogenic autoinflammatory diseases are caused by pathogenic variants in genes that regulate innate immune responses, and characterized sterile systemic inflammatory episodes. Since symptoms can overlap within this rapidly expanding disease category, accurate genetic diagnosis is of the utmost importance to initiate early inflammation-targeted treatment prevent clinically significant or life-threatening complications. Initial recommendations for were limited a...
Dendritic cells (DC) are a system of antigen-presenting specialized in interaction with T cells. Recently it has been reported that DC can produce CC (β) chemokines attract In this study we isolated mouse fractalkine and macrophage-derived chemokine (MDC) belonging to CX3C (δ) families, respectively, from bone marrow-derived mature DC. While expression fractalkine, which so far only examined the brain vitro endothelial far, was rather ubiquitous, MDC, be synthesized by macrophages DC,...
We have identified and characterized a cDNA encoding novel Ca2+-binding protein named calumenin from mouse heart by the signal sequence trap method. The deduced amino acid (315 residues) of contains an amino-terminal six (EF-hand) motifs shows homology with reticulocalbin, Erc-55, Cab45. These proteins seem to form new subset EF-hand family expressed in lumen endoplasmic reticulum (ER) Golgi apparatus. Purified had ability. carboxyl-terminal tetrapeptide His-Asp-Glu-Phe was shown be...
Abstract Generalized pustular psoriasis is a distinct type of characterized by recurrent febrile attacks with disseminated subcorneal pustules on generalized skin rashes. Recently, homozygous and compound heterozygous mutations the IL 36 RN gene, which encodes anti‐inflammatory cytokine interleukin (IL)‐36 receptor antagonist, were identified in familial sporadic cases various ethnicities psoriasis. Here we report 39‐year‐old J apanese male patient who had suffered from repeated since...
Abstract Background This study evaluated the efficacy and safety of baricitinib (Janus kinase-1/2 inhibitor), in adult pediatric Japanese patients with Nakajo-Nishimura syndrome/chronic atypical neutrophilic dermatosis lipodystrophy elevated temperature (NNS/CANDLE), stimulator interferon genes-associated vasculopathy onset during infancy (SAVI), or Aicardi-Goutières syndrome (AGS). Methods A Phase 2/3, multicenter, open-label (NCT04517253) was conducted across 52 weeks. Primary endpoint...
Abstract Background Prurigo nodularis (PN), a chronic inflammatory skin condition, adversely affects the quality of life affected individuals. Current treatment options for PN in Japan are limited. Objectives To evaluate optimal dose, efficacy and safety long-term with nemolizumab patients Japan. Methods In 16-week double-blind phase II/III study, aged ≥ 13 years were randomly assigned (1 : 1 1) to 30-mg, 60-mg or placebo groups, concomitant topical corticosteroids, every 4 weeks. The...