A5016738447- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Cancer and Skin Lesions
- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Cutaneous Melanoma Detection and Management
- Eosinophilic Disorders and Syndromes
- Asthma and respiratory diseases
- Contact Dermatitis and Allergies
- Nonmelanoma Skin Cancer Studies
- Skin and Cellular Biology Research
- Allergic Rhinitis and Sensitization
- Soft tissue tumor case studies
- Drug-Induced Adverse Reactions
- Tumors and Oncological Cases
- Genetic and rare skin diseases.
- Advancements in Transdermal Drug Delivery
- Vascular Tumors and Angiosarcomas
- Dermatological and Skeletal Disorders
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Skin Diseases and Diabetes
- Mast cells and histamine
Dokkyo Medical University
2020-2024
Dokkyo Medical University Saitama Medical Center
2014-2024
Social Insurance Saitama Chuo Hospital
2020-2024
Oita University
2007-2016
Tohoku University
2001
Oita University Hospital
1997-1998
Oita Medical Center
1986-1991
UNC Lineberger Comprehensive Cancer Center
1988
University of North Carolina at Chapel Hill
1988
Cancer Research Center
1988
There is mounting evidence that Th2 cytokines adversely affect skin barrier functions and contribute to the pathogenesis of atopic dermatitis (AD). AD also characterized by abnormal cohesion in stratum corneum (SC). However, contribution this abnormality remains unknown. This study examined effects IL-4, a prototypic cytokine, on SC. Structural physiological assessments revealed repeated intradermal injections IL-4 compromised SC normal hairless mice. Two potential mechanisms were explored...
Abstract Background Prurigo nodularis (PN), a chronic inflammatory skin condition, adversely affects the quality of life affected individuals. Current treatment options for PN in Japan are limited. Objectives To evaluate optimal dose, efficacy and safety long-term with nemolizumab patients Japan. Methods In 16-week double-blind phase II/III study, aged ≥ 13 years were randomly assigned (1 : 1 1) to 30-mg, 60-mg or placebo groups, concomitant topical corticosteroids, every 4 weeks. The...
SUMMARY Previous studies using in vitro systems with various stimuli have shown that PBMC from patients AD show increased levels of IL-4 but decreased interferon-gamma (IFN-γ) compared normal controls. However, conditions do not always mimic the vivo condition. We therefore believe it is important to quantify expression these cytokines freshly isolated PBMC. This study examines IFN-γ, and IL-13 mRNA adult AD, psoriasis vulgaris healthy adults, semiquantitative reverse...
Abstract Anterior chamber-associated immune deviation (ACAID), a manifestation of ocular privilege, prevents Th1-dependent delayed hypersensitivity from developing in response to eye-derived Ags, thereby preserving vision. Since Th2-type cells have recently been shown mediate destructive inflammation the cornea, we wondered whether pre-emptive induction ACAID could inhibit Th2 responses. Using murine model OVA -specific, Th2-dependent pulmonary inflammation, pretreated susceptible mice by...
Atopic dermatitis is characterized by Th2-dominant immunity. Recently many intracellular molecules have been reported to regulate cytokine expression and T cell differentiation. GATA-3 T-box expressed in cells (T-bet) are transcription factors that play a critical role the development of Th2 Th1 immunity, respectively. Suppressor signalling (SOCS)-3 SOCS-5, negative regulators induced IL-12 IL-4, Txk factor activates IFN-gamma gene directly. The present study was designed identify...
SUMMARY Chemokines play an important role in the selective movement of leucocytes into inflammatory areas and they also activate various cells inflamed tissues. However, it is unclear which are main sources chemokines actual diseases, even though both mononuclear non-inflammatory resident able to produce vitro former target chemokines. To clarify roles that produced by AD, we measured levels vivo mRNA for IL-8 MIP-1α, as well level regulated upon activation normal T cell expressed secreted...
Abstract Itchy skin or pruritus is a common cutaneous symptom that causes an urge to scratch, and the role of interleukins (IL) in itchy has been widely studied. IL‐4 IL‐13 are known induce chronic itch. Similarly, direct IL‐31 inducing itch demonstrated clinical situations such as atopic dermatitis prurigo nodularis. Moreover, receptor α antibodies (dupilumab) A (nemolizumab) inhibit pruritus. However, interplay between these ILs remains unclear. Therefore, we investigated reciprocal...
BACKGROUND Malignant skin tumors rarely spread along nerves. Complete resection of involved nerves is often unsuccessful. OBJECTIVE In the treatment with perineural invasion, surgeons should accurately estimate extent distant spread. METHODS We report six cases cancers, including two basal cell carcinomas, squamous and neurotropic malignant melanomas, that invaded nerve or spaces. RESULTS three cases, developed on face infraorbital its branches. Two patients suffered from aid burn scars...
Abstract To investigate the relationship between ischemic time and rejection against allotransplants, vascularized cutaneous flaps from groin of Brown Norway rats were transplanted to Lewis rats. The was set at 1 hour 6 hours for comparison. Cycrosporine A used as immunosuppressant. results showed more severe in group vivo , vitro examination using mixed lymphocyte reaction assay also demonstrated a greater antidonor response hours‐ischemic than that hour‐group. Immunohistochemical study MHC...
Abstract Significant decreases in hormonal levels at menopause induce physiological and functional discomfort the skin. Representative changes are based on so‐called dry However, there is no evidence to explain mechanism, even though hydration of stratum corneum ( SC ) women comparable with that premenopause but enhanced by hormone replacement therapy. This study objective was evaluate structural ovariectomized mice model menopause. Hydration , recovery permeability barrier function,...
Schnitzler syndrome is a rare disorder with chronic urticaria, and there no report summarizing the current status in Japan.A nationwide survey of major dermatology departments Japan was conducted 2019. We further performed systematic search PubMed Ichushi-Web, using keywords "Schnitzler syndrome" "Japan" then contacted corresponding authors or physicians for information.Excluding duplicates, total 36 clinically diagnosed cases were identified from 1994 through spring 2022, male to female...
Neurofibromatosis type 1 (NF1) is an autosomally dominant inherited disorder characterized by multiple pigmented skin spots (café-au-lait spots) and neurofibroma. NF1 associated with a wide variety of benign or malignant tumors. We report patient who received surgical treatment for rectal carcinoma multifocal small intestinal gastrointestinal stromal tumors (GISTs). A 70-year-old female was referred to our hospital after positive fecal occult blood test. Locally advanced detected in the...