A5015594627- Skin and Cellular Biology Research
- Dermatology and Skin Diseases
- Nail Diseases and Treatments
- Autoimmune Bullous Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Urticaria and Related Conditions
- Dermatological and Skeletal Disorders
- Wnt/β-catenin signaling in development and cancer
- Plant Pathogens and Fungal Diseases
- Hair Growth and Disorders
- Dermatologic Treatments and Research
- Cellular Mechanics and Interactions
- Allergic Rhinitis and Sensitization
- Cancer and Skin Lesions
- Contact Dermatitis and Allergies
- melanin and skin pigmentation
- Wound Healing and Treatments
- Genetic and rare skin diseases.
- Fungal Infections and Studies
- Skin Protection and Aging
- Advancements in Transdermal Drug Delivery
- Food Allergy and Anaphylaxis Research
- Cutaneous lymphoproliferative disorders research
- Ubiquitin and proteasome pathways
- Plant Reproductive Biology
Juntendo University Urayasu Hospital
2016-2025
Juntendo University
2009-2024
Juntendo University Hospital
1995-2017
Tokushima University
2005
Baylor College of Medicine
1998-2000
Juntendo University Shizuoka Hospital
1999
Jefferson Institute
1995
Thomas Jefferson University
1995
The epidermal cornified cell envelope (CE) is a complex protein–lipid composite that replaces the plasma membrane of terminally differentiated keratinocytes. This lamellar structure essential for barrier function skin and has ability to prevent loss water ions protect from environmental hazards. major protein CE loricrin, contributing ∼70% by mass. We have generated mice are deficient this protein. These showed delay in formation embryonic development. At birth, homozygous mutant weighed...
Ablative laser resurfacing is an effective treatment for acne scars. However, edema and prolonged erythema are common. Additionally, scarring hyperpigmentation often induced. A new concept of called fractional photothermolysis has been designed to create microscopic thermal wounds achieve skin rejuvenation without significant side-effects. We treated 10 patients with scars using this system (Reliant Fraxel SR Laser). All the were successfully minimal adverse effects. The represents optional method
We found CARD14 mutations (2 de novo novel and another previously reported mutation) in 3 of patients with pityriasis rubra pilaris (PRP) type V, but not PRP other types. Our findings, combined the published literature, suggest that V PRP, both familial sporadic, can be caused by mutations. Detailed clinical observation revealed all displayed unique patchy macular brown hyperpigmentation.To further determine how often have pathogenic to elucidate which subtype is mutations.We sequenced...
Abstract Background Prurigo nodularis (PN), a chronic inflammatory skin condition, adversely affects the quality of life affected individuals. Current treatment options for PN in Japan are limited. Objectives To evaluate optimal dose, efficacy and safety long-term with nemolizumab patients Japan. Methods In 16-week double-blind phase II/III study, aged ≥ 13 years were randomly assigned (1 : 1 1) to 30-mg, 60-mg or placebo groups, concomitant topical corticosteroids, every 4 weeks. The...
Abstract Common warts (verruca vulgaris) are the most commonly seen benign cutaneous tumors. However, in hands and feet regions often respond poorly to treatment, some resistant more than 6 months of treatment with currently available modalities, including cryotherapy, being defined as refractory warts. We investigated usefulness long‐pulsed neodymium:yttrium–aluminum–garnet ( LP ‐ N d: YAG ) for The clinical trial was conducted on 20 subjects (11 male, nine female) a total 34 lesions...
Mutations in the cornified cell envelope protein loricrin have been reported recently some patients with Vohwinkel syndrome (VS) and progressive symmetric erythrokeratoderma (PSEK). To establish a causative relationship between mutations these diseases, we generated transgenic mice expressing COOH-terminal truncated form of that is similar to expressed VS PSEK patients. At birth, (ML.VS) exhibited an epidermal barrier dysfunction. 4 d after high-expressing animals showed generalized scaling...
Lipocalin-2 (LCN2), a protein secreted mainly by activated neutrophils, has been associated with neurodegeneration, obesity, and inflammatory responses. Serum LCN2 concentration reported elevated in patients psoriasis, but lower atopic dermatitis (AD). Spinal astrocyte-derived was found to be involved enhancement of itch mouse model AD. However, the relationship between psoriasis not determined. Objective. This study examined correlation serum levels degrees psoriasis. concentrations were...
Abstract Perforating dermatoses are a heterogeneous skin disease group defined by transepidermal elimination of various materials. Four classical forms primary perforating dermatosis have been described, where the mechanism represents hallmark disease: acquired reactive collagenosis, elastosis perforans serpiginosa, Kyrle’s and folliculitis. Acquired collagenosis presents with collagen fibers. Elastosis serpiginosum elastic abnormal keratin. In folliculitis, it is content follicle. We...