A5023615321- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Anesthesia and Sedative Agents
- Viral gastroenteritis research and epidemiology
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- Mosquito-borne diseases and control
- Airway Management and Intubation Techniques
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Mental Health Treatment and Access
- Viral Infections and Vectors
- interferon and immune responses
- Health disparities and outcomes
- RNA Interference and Gene Delivery
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Obstructive Sleep Apnea Research
- Suicide and Self-Harm Studies
- Nausea and vomiting management
- Neurogenesis and neuroplasticity mechanisms
- Youth Substance Use and School Attendance
Chongqing Medical University
2024-2025
Children's Hospital of Chongqing Medical University
2025
Children's Hospital of Fudan University
2010-2024
Hunan University
2020-2024
Southern University of Science and Technology
2022-2024
Shenzhen KangNing Hospital
2014-2024
Partnership for Economic Policy
2023
Harbin Institute of Technology
2023
Jilin University
2021
Third Affiliated Hospital of Southern Medical University
2019-2021
The epidermal cornified cell envelope (CE) is a complex protein–lipid composite that replaces the plasma membrane of terminally differentiated keratinocytes. This lamellar structure essential for barrier function skin and has ability to prevent loss water ions protect from environmental hazards. major protein CE loricrin, contributing ∼70% by mass. We have generated mice are deficient this protein. These showed delay in formation embryonic development. At birth, homozygous mutant weighed...
Abstract The mammalian olfactory neuroepithelium provides a unique system for understanding the regulation of neurogenesis by adult neural stem cells. Recently, mouse horizontal basal cells (HBCs) were identified as that regenerate receptor neurons (ORNs) and non-neuronal cell types only after extensive injury epithelium (OE). Here we report broader spectrum action these We show even during normal neuronal turnover, HBCs actively generate throughout adulthood. This occurs in temporally...
Abstract To control the ongoing COVID‐19 pandemic, a variety of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines have been developed. However, rapid mutations SARS‐CoV‐2 spike (S) protein may reduce protective efficacy existing which is mainly determined by level neutralizing antibodies targeting S. In this study, we screened prevalent S and constructed 124 pseudotyped lentiviral particles carrying these mutants. We challenged pseudoviruses with sera vaccinated Sinovac...
Abstract Mouse models for cancer represent powerful tools to analyze the causal role of genetic alterations in development. We have developed a novel mouse model that allows focal activation mutations stratified epithelia. Using this system, we demonstrate an oncogenic K-rasG12D allele oral cavity induces tumor formation. The lesions develop these mice are classified as benign squamous papillomas. Interestingly, tumors exhibit changes expression pattern keratins similar those observed human...
Abstract We are using Drosophila as a model system for analysis of immunity and tumor formation have conducted two types screens enhancer detector strains to find genes related these processes: expressed in the immune (type A, hemocytes, lymph glands fat body) increased expression by bacterial infection B). For type tissue-specific reporter gene activity was determined. B, variation detection devised which β-galactosidase is assayed spectrophotometrically with without infection. Because...
Increasing evidence supports inter-species transmission of SARS-CoV-2 variants from humans to domestic or wild animals during the ongoing COVID-19 pandemic, which is posing great challenges epidemic control. Clarifying host range emerging will provide instructive information for containment viral spillover. The spike protein (S) key determinant receptor utilization, and therefore amino acid mutations on S probably alter range. Here, evaluate impact mutations, we tested 27 pseudoviruses...
Abstract In addition to the evaluation of high-order loop contributions, precision and predictive power perturbative QCD (pQCD) predictions depends on two important issues: (1) how achieve a reliable, convergent fixed-order series, (2) reliably estimate contributions unknown higher-order terms. The recursive use renormalization group equation, together with Principle Maximum Conformality (PMC), eliminates scheme-and-scale ambiguities conventional pQCD series. result is conformal,...
Abstract Tetraparvovirus is an emerging parvovirus infecting a variety of mammals and humans, associated with human diseases including severe acute respiratory infection encephalitis syndrome. In the present study, ungulate 1 (formerly known as bovine hokovirus) strain HNU-CBY-2023 was identified characterized from diseased Chinese Simmental Hunan province, China. The nearly complete genome 5346 nt in size showed genomic identities 85-95.5% to strains GenBank, indicating rather genetic...
Biliary atresia (BA) is a devastating liver disease in infants. Progressive hepatic fibrosis often observed postoperative patients with BA even after successful Kasai portoenterostomy procedure. MicroRNA-222 (miRNA) has been linked to the activation of stellate cells and progression fibrosis.In this study, miR-222 expression profile infants anicteric choledochal cyst (CC) was determined. The functional effect inhibition on growth human cell line LX-2 also evaluated. downstream signaling...
MicroRNAs (miRNAs) have been demonstrated that play a critical role in tumorigenesis. The aim of this study is to identify the functional miR-378 cholangiocarcinoma (CCA). Quantitative real-time polymerase chain reaction (qRT-PCR) was used
SARS-CoV-2, the newly identified human coronavirus causing severe pneumonia epidemic, was probably originated from Chinese horseshoe bats. However, direct transmission of virus bats to humans is unlikely due lack contact, implying existence unknown intermediate hosts. Angiotensin converting enzyme 2 (ACE2) receptor but only ACE2s certain species can be utilized by SARS-CoV-2. Here, we evaluated and ranked receptor-utilizing capability various phylogenetic clustering sequence alignment with...
Abstract Suicide is increasingly recognized as a major public health concern among migrant workers in China. Despite negative mental and coping styles being core themes found suicide notes, there scarce research addressing the theoretical framework of underlying mechanisms between these variables. The study was designed to examine relationships mental, styles, risk workers. It hypothesized that would exert positive effect on via increased coping. Using cross-sectional design, conducted using...
Abstract Genomic recombination is an important driving force for viral evolution, and events have been reported severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the Coronavirus Disease 2019 pandemic, which significantly alter infectivity transmissibility. However, it difficult to identify recombination, especially low-divergence viruses such as SARS-CoV-2, since hard distinguish from in situ mutation. Herein, we applied information theory analysis developed VirusRecom, a...