A5036990849- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Chronic Myeloid Leukemia Treatments
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Advanced Breast Cancer Therapies
- Drug Transport and Resistance Mechanisms
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Renal Transplantation Outcomes and Treatments
- Multiple Myeloma Research and Treatments
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Cancer therapeutics and mechanisms
- Hematological disorders and diagnostics
- Cytomegalovirus and herpesvirus research
- Mesenchymal stem cell research
- Retinoids in leukemia and cellular processes
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
Fujian Medical University
2025
Nanjing Medical University
2014-2024
Jiangsu Province Hospital
2014-2024
MicroRNAs (miRNAs) have been shown to play critical roles in regulating the progress of leukemia. We performed miRNA expression profile six Chinese patients with chronic lymphocytic leukemia (CLL), and peripheral B cells from pooled 30 healthy donors, using a platform containing 866 human miRNAs. The most frequent changes miRNAs CLL included downregulation miR-126, miR-572, miR-494, miR-923, miR-638, miR-130a, miR-181a miR-181b up-regulation miR-29a, miR-660, miR-20a, miR-106b, miR-142-5p,...
Granulomatous mastitis (GM) poses challenges in diagnosis and treatment due to its similarities with other breast diseases like cancer. The comparative study evaluated the efficacy safety of a vacuum-assisted biopsy device minimally invasive excisions compared traditional wide local excisions. technique offers benefits such as precise tissue removal, reduced damage healthy tissue, shorter surgery recovery times, lower postoperative complication risks. found that had comparable excision...
Chronic lymphocytic leukemia (CLL) is the most common in western world. Alterations microRNAs (miRNAs) expression have been proposed to play a role CLL pathogenesis. Dicer and Drosha are main regulators of miRNA biogenesis, deregulation their has indicated as possible cause alterations observed various cancers. To investigate CLL, we assessed correlation with other prognostic factors, including Binet stages, immunoglobulin heavy chain variable gene (IGHV) mutation status, TP53 ZAP-70 protein...
Aberrant activation of lymphoid enhancer-binding factor-1 (LEF1) has been identified in several cancers, including chronic lymphocytic leukemia (CLL). As a key transcription factor the Wnt/β-catenin pathway, LEF1 helps to regulate important genes involved tumor cell death mechanisms. In this study, we determined gene expression levels CLL (n = 197) and monoclonal B-cell lymphocytosis (MBL) 6) patients through real-time RT-PCR. was significantly up-regulated both MBL compared with normal B...
Ibrutinib, a first-generation Bruton's tyrosine kinase (BTK) inhibitor, could improve immunity of relapsed or refractory (R/R) chronic lymphocytic leukemia/small lymphoma (CLL/SLL) patients. Whether zanubrutinib, second-generation selective BTK has similar effects as ibrutinib remains to be determined. Dynamics number and immunophenotype immune cells during zanubrutinib treatment in 25 R/R CLL/SLL patients were examined by flow cytometry blood routine tests. The expression intensity...
Complement deficiencies have been identified in many chronic lymphocytic leukemia (CLL) patients. Supplying fresh frozen plasma (FFP)-derived complement can enhance complement-dependent cell lysis by the rituximab. The objective of our study was to evaluate clinical efficacy and safety treatment adding FFP rituximab fludarabine refractory CLL Twenty-two patients were treated with two units followed rituximab, 375 mg/m(2), as a single agent, repeated every 1-2 weeks. Patients received median...
Loss of cylindromatosis gene (CYLD) expression has been observed in various cancers, including chronic lymphocytic leukemia (CLL). As a deubiquitination enzyme, CYLD regulates the proliferation, development and activation lymphoid cells. Here we determined mRNA by quantitative polymerase chain reaction (PCR) 125 patients with CLL. was considerably down-regulated CLL cells compared to normal B Low associated unmutated status immunoglobulin heavy-chain variable-region (IGHV) (p = 0.0018) CD38...
Abstract A single nucleotide polymorphism (SNP) at position 309 in the promoter region of MDM2 leading to increased expression and attenuated function p53 has recently been suggested as an unfavorable prognostic marker chronic lymphocytic leukemia (CLL) although this questioned. The SNP309 genotypes 173 CLL patients 260 healthy controls were detected by polymerase chain reaction–restriction fragment length (PCR–RFLP) method, which was confirmed direct DNA sequencing. Compared with T/T...
Cytogenetic features have an important role in the definition of distinct disease subsets CLL. The deletion 6q is known to occur at a relatively low frequency CLL, and detailed analysis hematologic clinical patients with CLL limited. To verify incidence prognostic significance Chinese fluorescence situ hybridization (FISH) was used 240 del(6q23) found 18 (7.5%), only five had 6q23 as sole abnormality. Strong correlations between parameters were not found. A difference terms survival compared...
Abstract T(15;17) is the most common chromosomal aberration in patients with acute promyelocytic leukemia (APL), leading to formation of PML‐RARα fusion gene. In a small subset APL, RARα gene fused different partners. Here, we report rare APL case STAT5B‐RARα transcript. Cytomorphologic and immunophenotypic analyses showed typical features APL. However, cytogenetic analysis normal karyotype, interphase fluorescence situ hybridization (FISH) negative. Quantitative RT‐PCR also negative but...
Chronic lymphocytic leukemia (CLL) is the most common type of adult in Western countries, however, it infrequent Eastern countries. The direct antiglobulin test (DAT) may be positive at some time during disease course CLL. aim this study was to explore prognostic impact DAT diagnosis Chinese patients with In 123 CLL, 34 (27.6%) presented a diagnosis. However only 12 (9.8%) developed autoimmune hemolytic anemia (AHA). According correlation analysis, advanced Binet stage (p < 0.001), high...
The current study presents the case of a 78-year-old male with concurrent chronic neutrophilic leukemia (CNL) and multiple myeloma (MM) who developed acute myeloid after two years treatment hydroxyurea, cyclophosphamide, prednisone thalidomide. patient presented mature leukocytosis, hepatosplenomegaly, high neutrophil alkaline phosphatase score an absence Philadelphia chromosome or BCR-ABL fusion gene. A bone marrow aspirate smear biopsy indicated that CNL coexisted plasma cell neoplasm. In...
Multidrug resistance 1 (MDR1) gene encodes P-glycoprotein (P-gp), which acts as an efflux pump and provides cell protection against various substances, its single-nucleotide polymorphisms (SNPs) are associated with the development of malignant hematologic diseases. The present study aimed at investigating whether MDR1 SNPs haplotype variants were correlated susceptibility to multiple myeloma (MM). A total 115 MM patients 153 healthy controls from Jiangsu Han population enrolled genotyped by...
Abstract Background With the development of Hematopoietic Stem Cell Transplantation (HSCT) technology, increasing numbers elderly patients were undergoing allogeneic HSCT and with hematologic malignancies could benefit most from it. Preformed donor-specific human leukocyte antigen (HLA) antibodies (DSA) associated graft failure in HLA-mismatched absence DSA was main criterion selecting donor. Except for sensitization events such as transfusion, pregnancy or previous transplantation, ageing...