A5012632336- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Lipid metabolism and disorders
- RNA modifications and cancer
- Connective Tissue Growth Factor Research
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Neuroendocrine Tumor Research Advances
- Systemic Lupus Erythematosus Research
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Lymphoma Diagnosis and Treatment
- Inflammatory Bowel Disease
- Oral microbiology and periodontitis research
- Semiconductor materials and devices
- Cancer therapeutics and mechanisms
- Protein Degradation and Inhibitors
- Neurological diseases and metabolism
- Cell death mechanisms and regulation
- Pregnancy-related medical research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Genetic Syndromes and Imprinting
Nanjing University
2004-2025
Beijing University of Chinese Medicine
2024
Shandong Provincial Hospital
2023-2024
Shandong University
2023-2024
Nanjing Medical University
2014-2023
Jiangsu Province Hospital
2011-2023
Shandong First Medical University
2023
Nanjing Maternity and Child Health Care Hospital
2023
Shanghai Children's Medical Center
2016-2020
Shanghai Jiao Tong University
2020
Abstract The long noncoding RNAs (lncRNAs) have been clarified to participate in hepatocellular carcinoma (HCC) as a biomarker. We carried out the present study order identify HCC-related lncRNAs and elucidate functional roles development progression of HCC. Our previous has provided that LINC01225 may be an gene. Here, we verified was upregulated Knockdown resulted inhibited cell proliferation invasion with activated apoptosis cycle arrest vitro . Overexpression knockdown cells presented...
Abstract Objectives The aim of this study was to investigate effects mineral trioxide aggregate ( MTA ) on odonto/osteogenic differentiation bone marrow stromal cells BMSC s) from craniofacial bones. Materials and methods Craniofacial s were isolated rat mandible their proliferation, MAPK pathway involvement subsequently investigated, in vitro . MTT (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2,5‐tetrazoliumbromide) assay performed evaluate proliferation the ‐treated cells. Alkaline...
Disulfidptosis is a recently discovered programmed cell death pathway. However, the exact molecular mechanism of disulfidptosis in cutaneous melanoma remains unclear.In this study, clustering analysis was performed using data from public databases to construct prognostic model, which subsequently externally validated. The biological functions model genes were then investigated through various experimental techniques, including qRT-PCR, Western blotting, CCK-8 assay, wound healing and...
Background: Breast invasive carcinoma (BRCA) is a malignant tumor with high morbidity and mortality, the prognosis still unsatisfactory. Both ferroptosis cuproptosis are apoptosis-independent cell deaths caused by imbalance of corresponding metal components in cells can affect proliferation rate cancer cells. The aim this study was to develop prognostic model cuproptosis/ferroptosis-related genes (CFRGs) predict survival BRCA patients. Methods: Transcriptomic clinical data for breast...
Tetrahydromethanopterin (H4MPT) is a specialized coenzyme found in methanogenic archaea and methylotrophic bacteria, essential for one‐carbon C1 transfer redox reactions processes like methanogenesis. However, its structural complexity limited availability hinder use studying archaeal metabolism H4MPT‐dependent enzymes. Inspired by the success of NAD(P)H biomimetic compounds, we employed similar simplification strategy methylene‐H4MPT, designing four mimics (mimics 1–4) that retain crucial...
Extraperitoneal laparoscopic radical prostatectomy (E-LRP) and transperitoneal robotic-assisted (TRA-LRP) are two types of widely used at present, but the comparative study between them is limited. We aimed to compare E-LRP with TRA-LRP in treatment low- or intermediate-risk prostate cancer (PCa). From June 2020 May 2024, our department, a total 80 patients PCa, including 45 cases who received (E-LRP group) another 35 (TRA-LRP group), were enrolled research. All followed up for 6-24 months....
Autologous hematopoietic stem cell (HSC) and mesenchymal (MSC) transplantation is currently being evaluated as a novel treatment for autoimmune diseases, such systemic lupus erythematosus (SLE). Here we report case of autologous HSC combined with MSCs in 25-year-old severe SLE patient multiple life-threatening complications refractory to conventional cyclophosphamide (CYC) therapy. After pretreated CYC, fludarabine antithymocyte globulin, the was transplanted CD34+HSCs by intravenous...
Summary The role of NOD-like receptor family (NLRP3) has been confirmed in various inflammatory diseases. association between NLRP3 and hyper-bileacidaemia during the sepsis remains unclear. We aimed to investigate whether silencing protects against sepsis-induced hyper-bileacidaemia. Sepsis was induced by caecum ligation puncture (CLP). Gene performed injecting rats with short hairpin RNA plasmids (NLRP3 shRNA) 48 h before surgery. Rats were divided into four groups: group 1: sham; 2:...
Metabolomics has been applied to explore altered metabolite profiles in disease and identify unique metabolic signatures specific certain pathologies. The aim of the current study is characterize profile patients diagnosed with lupus nephritis (LN) new insights into underlying processes. A metabolomic approach using ultra-high-performance liquid chromatography coupled high-resolution mass spectrometry (UPLC-HRMS) was developed serum samples from 32 LN patients, 30 idiopathic nephrotic...
Linear alkyl benzene (LAB) is an attractive solvent for large scale liquid scintillator detectors due to its low toxicity, high flash point, and good compatibility with acrylic. Very optical purity required be used in detectors. We studied several LAB samples collected from two companies by measuring the light attenuation length, UV-Vis absorption spectrum, some other properties. Some of them have not transparency. Compositions these were then analyzed GC-MS dimensional GCxGC/MS. impurities,...
This randomized, double-blind, parallel-design study compared the short-term effects of rosuvastatin and atorvastatin on serum lipids markers inflammation endothelial function in patients with stable atherosclerosis. Patients received either 10 mg/day ( n = 18) or 20 18), orally, for 4 weeks. Serum lipids, high-sensitivity C-reactive protein (hsCRP), Rho-associated coiled-coil containing kinase (ROCK) activity flow-mediated dilation (FMD) brachial artery were assessed before after therapy....
Objective: To explore the effect of F-box and WD-40 domain protein 7 (FBXW7) gene mutation on prognosis immunotherapy in patients with non-small cell lung cancer (NSCLC). Methods: (1) The clinical data 125 advanced NSCLC First Affiliated Hospital Nanjing Medical University from January 2019 to June 2021 were collected. There 70 males 55 females, a median age [M (Q1, Q3)] 64(57, 70) years. correlation FBXW7 efficacy was analyzed. (2) Data set treated cBioPortal database downloaded. A total...
Abstract. Studies have shown that regular physical activity (PA) may re-duce the risk of stroke. Nevertheless, protective effect pre-stroke PA on post-stroke functional status in patients treated with endovascular throm-bectomy (EVT) is still uncertain. For this study, hospitalized acute ischemic stroke were selected, all whom underwent EVT after occlusion large vessels anterior circulation. The levels before assessed by International Physical Activity Questionnaire, and outcome indicators...