A5101903264- Immune cells in cancer
- Infant Nutrition and Health
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Iron-based superconductors research
- 2D Materials and Applications
- Fungal Biology and Applications
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Chalcogenide Semiconductor Thin Films
- Perovskite Materials and Applications
- Magnetic and transport properties of perovskites and related materials
- Galectins and Cancer Biology
- Advanced Condensed Matter Physics
- Polysaccharides and Plant Cell Walls
- Immune responses and vaccinations
- Seaweed-derived Bioactive Compounds
- Photodynamic Therapy Research Studies
- Cell death mechanisms and regulation
- IL-33, ST2, and ILC Pathways
- Organ and Tissue Transplantation Research
- Bone Metabolism and Diseases
- Herbal Medicine Research Studies
- Peptidase Inhibition and Analysis
- Phagocytosis and Immune Regulation
Center for High Pressure Science and Technology Advanced Research
2023-2025
Physical Sciences (United States)
2025
Shanghai Jiao Tong University
2022-2025
Yunnan University
2025
Center for Life Sciences
2025
Shanghai Children's Medical Center
2022-2025
Nanjing Medical University
2011-2024
Kangda College of Nanjing Medical University
2024
Soochow University
2013-2023
Wannan Medical College
2021
Macrophages are multifunctional cells that perform diverse roles in health and disease, considered the main source of inflammatory cytokines affected joints patients with rheumatoid arthritis (RA). M2 macrophages well known as anti-inflammation wound-healing cells; however recent evidence suggests they can also promote inflammation RA, although underlying mechanism remains to be clarified. Based upon our finding lactoferrin (LTF)-containing IgG immunocomplex (LTF-IC), found elevated RA sera,...
Two-dimensional (2D) Fe chalcogenides with their rich structures and properties are highly desirable for revealing the torturous transition mechanism of exploring potential applications in spintronics nanoelectronics. Hydrostatic pressure can effectively stimulate phase transitions between various ordered states, allowing one to successfully plot a diagram given material. Herein, structural evolution transport characteristics 2D FeTe were systematically investigated under extreme conditions...
β-Glucans derived from various sources such as yeast cell walls and medicinal mushrooms are considered valuable biological response modifiers for their ability to enhance the activity of immune cells, aid in wound healing help prevent infections. We herein characterize structure a novel water-soluble polysaccharide (Zhuling polysaccharide, ZPS) fruit bodies mushroom Polyporus umbellatus investigate its immunobiological function. ZPS has molecular mass 2.27 x 10(3) kDa contains >90% d-glucose...
Background Tumor-associated macrophages (TAMs) resemble M2-polarized cells with potent immunosuppressive activity and play a pivotal role in tumor growth progression. Converting TAMs to proinflammatory M1-like phenotype is thus an attractive strategy for antitumor immunotherapy. Methods A mouse IgG 1 (kappa) monoclonal Ab, M-860, specific human lactoferrin (LTF) was generated by using the traditional hybridoma cell fusion technology. were culturing CD14 + monocytes tumor-conditioned media...
The Vici syndrome protein EPG5 acts as a tethering factor determining the fusion specificity of autophagosomes with late endosomes/lysosomes. Here we demonstrated that during C. elegans development, EPG-5 modulates SMA and MAB TGFB/TGF-β signaling in controlling body size also WNT regulating cell migration. is required for retrograde trafficking TGFB receptor SMA-6 WLS/Wntless homolog MIG-14. In epg-5 mutants, MIG-14 are trapped within hybrid endosomal structures, which colocalize SNX-1-...
<title>Abstract</title> Charge-density waves (CDWs) are symmetry-broken quantum states characterized by periodic modulations of electron density. While the Peierls’ distortion model has effectively described CDW dynamics in low-dimensional systems and cryogenic temperatures, robust evidence for three-dimensional (3D) under ambient conditions thin, mechanisms driving such condensate still debate. Here, we observe pressure-induced CDWs Lu<sub>2</sub>Ti<sub>2</sub>O<sub>7</sub> crystallite...
Abstract Lactoferrin (LTF), an important first line defense molecule against infection, is a common target for humoral autoimmune reactions in humans. Since LTF multifunctional protein capable of activating innate immune cells via various surface receptors, we hypothesized that LTF-containing complexes (ICs) (LTF-ICs), likely formed patients with high titer anti-LTF autoantibodies, could possess unique monocyte/macrophage-activating properties compared other ICs. ELISA analysis on serum...
Abstract Flexible perovskite solar cells (F‐PSCs) are highly promising for both stationary and mobile applications because of their advantageous features, including mechanical flexibility, lightweight thin nature, cost‐effectiveness. However, a number drawbacks, such as instability, make practical application difficult. Here, self‐welding dynamic diselenide that is triggered by visible light into the structure F‐PSCs to improve long‐term stability repairing cracks defects in absorber layer...
Abstract All‐inorganic Sn‐based halide perovskite CsSnI 3 is a promising candidate for solar cells (PSCs) owing to its narrower bandgap (≈1.3 eV) and lower toxicity as compared with traditional organic–inorganic hybrid Pb‐based counterparts. However, rapidly degrades in ambient air simultaneously generates intrinsic defect states, thus seriously impairing the optoelectronic property of film, well corresponding device performance. Herein, solid additive‐assisted chemical vapor deposition...
Ganoderma sinense is a Chinese unique medicinal fungus that has been used in folk medicine for thousands of years. Polysaccharides are considered to be biologically active ingredients due their immune-modulating functions. Previously we found GSP-2, new polysaccharide isolated from sinense, exerts an immunomodulatory effect human peripheral blood mononuclear cells but the underlying mechanism unclear. The present study aimed investigate how GSP-2 triggers immunologic responses and implicated...
Objective: The roles of long non-coding RNAs (lncRNAs) in the diagnosis clear cell renal carcinoma (ccRCC) are still not well-defined. We aimed to identify differentially expressed lncRNAs and mRNAs plasma ccRCC patients health controls systematically. Methods: Expression profile healthy was analyzed based on microarray assay. Gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway-based approaches were used investigate biological function signaling pathways mediated by mRNAs....
Polysaccharide-encapsulated fungi are the chief source of diseases in immunocompromised hosts such as those infected with human immunodeficiency virus or neutropenia patients. Currently available polysaccharide-protein conjugate vaccines mainly T cell dependent and usually ineffective weakened immune systems. In this study, laminarin, a well-characterized β-1,3-glucan, was conjugated prokaryotically expressed recombinant fragment (amino acids [aa] 39 to 272) calreticulin (rCRT/39-272), which...
The ferrimagnetic semiconductor ${\mathrm{Mn}}_{3}{\mathrm{Si}}_{2}{\mathrm{Te}}_{6}$ keeps the records of colossal magnetoresistance (CMR) and angular (AMR). Here we report tuning electronic transport properties via doping pressure in ${({\mathrm{Mn}}_{1\text{\ensuremath{-}}x}{\mathrm{Mg}}_{x})}_{3}{\mathrm{Si}}_{2}{\mathrm{Te}}_{6}$. As substitution nonmagnetic ${\mathrm{Mg}}^{2+}$ for magnetic ${\mathrm{Mn}}^{2+}$, transition temperature ${T}_{C}$ gradually decreases, while resistivity...
Lactoferrin (LTF), a multifunctional glycoprotein of the transferrin family mainly found in exotic secretions mammals, is an important defense molecule against not only microbial invasion but also tumors. It folds into two globular domains (N- and C-lobes) each containing iron-binding site. The cationic antimicrobial peptide N-lobe known to exert anti-tumor effect via non-receptor-mediated pathway. However, whether LTF C-lobe contributes its activity remains be investigated. In this study,...
Gryllodes sigillatus is a cricket widely distributed throughout the world. In this study, we reported first complete mitogenome sequence of Genus and inferred its phylogeny. The G. was 16,369 bp consisted control region typical set 37 genes. It AT-rich with strong codon usage bias possessed gene arrangement trnE-trnS1-trnN. Phylogenetic analysis indicated sister species to Velarifictorus hemelytrus, together belonging Family Gryllidae. Our findings would contribute understanding mitogenomic...
Soluble lactoferrin (LTF) is a versatile molecule that not only regulates the iron homeostasis, but also harbors direct microbicidal and immunomodulating abilities in mammalian body fluids. In contrast, little known about function of membrane-bound LTF (mbLTF), although its expression on human polymorphonuclear leukocytes (huPMNs) has been reported for decades. Given LTF/anti-LTF antibodies represent potential diagnostic/prognostic biomarker therapeutic target patients with immune disorders,...
Clinical data reveal that patients with allogeneic hematopoietic stem cell transplantation (HSCT) are vulnerable to infection and prone developing severe sepsis, which greatly compromises the success of transplantation, indicating a dysregulation inflammatory immune response in this clinical setting. Here, by using mouse model haploidentical bone marrow (haplo-BMT), we found uncontrolled macrophage inflammation underlies pathogenesis both LPS- E.coli-induced sepsis recipient animals...
Much progress has been made in recent years on the diagnostic value, Ag specificity, and pathogenic roles of autoantibodies correlated to development rheumatoid arthritis (RA) humans. However, carbohydrate Ag-specific that may also play important RA have largely ignored. In this article, we report serum levels Abs capable recognizing α1,4-polygalacturonic acid [(PGA); major structural component pectin] strongly correlate with The measurements PGA-specific (PGA-Abs) sera are comparable...