A5036366333- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Histone Deacetylase Inhibitors Research
- Biofuel production and bioconversion
- Neutropenia and Cancer Infections
- Fungal and yeast genetics research
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Cancer survivorship and care
- Lymphatic System and Diseases
- Endoplasmic Reticulum Stress and Disease
- Health Sciences Research and Education
- Plant pathogens and resistance mechanisms
- Plant Disease Resistance and Genetics
- Patient-Provider Communication in Healthcare
- Viral-associated cancers and disorders
- Lung Cancer Treatments and Mutations
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Amyotrophic Lateral Sclerosis Research
- Cancer-related Molecular Pathways
Nanjing University of Chinese Medicine
2021-2025
State Key Laboratory of Natural and Biomimetic Drugs
2022-2024
Huazhong Agricultural University
2024
Peking University
2022-2024
Nanfang Hospital
2018-2023
Zhejiang A & F University
2020-2023
Southern Medical University
2018-2023
Jiangsu Province Hospital
2016-2022
Nanjing Medical University
2016-2022
Nanjing Second Hospital
2017-2021
Cancer patients by immune checkpoint therapy have achieved long-term remission, with no recurrence of clinical symptoms cancer for many years. Nevertheless, more than half are not responsive to this due exhaustion. Here, we report a novel gene engineered exosome which is rationally designed engineering PD1 and simultaneously enveloping an adjuvant imiquimod (PD1-Imi Exo) boosting response blockage therapy. The results showed that PD1-Imi Exo had vesicular round shape (approximately 139 nm),...
Almonertinib is a third-generation EGFR-TKI, and studies on its resistance mechanisms are lacking. Cancer-associated fibroblasts (CAFs) can influence to targeted therapeutics, but their role mechanism of action in relation almonertinib unclear. The study explored relationships among glycolysis, cancer-associated (CAFs), resistance. A dose-escalation method was used develop the almonertinib-resistant cell line H1975AR. Hexokinase 2 (HK2) effects were evaluated using Cell Counting Kit-8...
Almonertinib is the initial third-generation EGFR-TKI in China, but its resistance mechanism unknown. Cancer-associated fibroblasts (CAFs) are essential matrix components tumor microenvironment, their impact on almonertinib This study aimed to explore correlation between CAFs and non-small cell lung cancer (NSCLC). The anti-cancer effects of NSCLC cells, as well reversal these mediated by CAFs, were validated through phenotypic experiments. Differential gene expression analysis, along with...
Cancer cells show increased glycolysis and take advantage of this metabolic pathway to generate ATP. The TP53-induced apoptosis regulator (TIGAR) inhibits aerobic protects tumor from intracellular reactive oxygen species (ROS)-associated apoptosis. However, the function TIGAR in survival acute myeloid leukemia remains unclear.We analyzed expression cytogenetically normal (CN-) AML patients correlations with clinical biological parameters. In vivo vitro, we tested whether may induce evaluated...
Cisplatin (CDDP), a widely used chemotherapeutic agent, can induce excessive granulosa cell apoptosis, follicle loss and even premature ovarian insufficiency (POI). However, the mechanism remains elusive, although some studies have indicated involvement of endoplasmic reticulum stress (ERS). The aim our study was to investigate possible ERS in CDDP-induced apoptosis loss.A POI mouse model generated by CDDP. ovaries samples were collected processed for isobaric tags relative absolute...
To describe the value, knowledge and implementation of evidenced-based practice (EBP) among Chinese nurse managers explore its influencing factors.Although much literature have reported importance in pushing EBP progress encouraged them to engage activities, extent which is unclear.A cross-sectional web-based survey was applied 1,166 recruited from 54 hospitals Guangdong Province, China. Descriptive statistics, t-tests or one-way ANOVAs, Spearman's correlation multiple regression analysis...
Phytopathogenic fungi normally secrete large amounts of CWDEs to enhance infection plants. In this study, we identified and characterized a secreted glycosyl hydrolase 5 family member in
To examine patient-caregiver concordances about psychological distress among Chinese patients with breast cancer undergoing chemotherapy and identify factors related to concordance family caregivers.Cross-sectional study.From October 2019 June 2020, 137 dyads were enrolled. Sociodemographic information, the thermometer (including problem list), Distress Disclosure Index Family Adaptability Cohesion Evaluation Scale used collect data. Data analysed using intraclass correlation coefficients...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscle paralysis, which followed degeneration of motor neurons in the cortex brainstem and spinal cord. The etiology sporadic ALS (sALS) still unknown, limiting exploration potential treatments. Ferroptosis new form cell death reported to be closely associated with Alzheimer's (AD), Parkinson's (PD), ALS. In this study, we used datasets (autopsy data blood data) from Gene Expression Omnibus (GEO)...
Background: Although previous studies reported that 26S proteasome non-ATPase regulatory subunit 2 (PSMD2) is involved in many human cancers. However, its clinical significance and function lung adenocarcinoma remain unclear. Here, we examined the prognostic immunological role of PSMD2 adenocarcinoma. Methods: The Cancer Genome Atlas (TCGA) was conducted to analyze expression verified using UALCAN. PrognoScan Kaplan-Meier curves were utilized assess effect on survival. cBioPortal database...
Background Receiving a breast cancer diagnosis and treatment is both physical emotional journey. Previous studies using single-source data have revealed common culture-specific experiences of patients living with cancer. However, few combined such from multiple sources. Thus, variety sources, the current study sought to explore women in China newly diagnosed, post-operative, or undergoing chemotherapy. We posited that even though channels through which they can express these experiences,...
The optimal treatment for elderly patients with acute myeloid leukemia (AML) remains a great challenge. Establishing more feasible, acceptable, accessible and safe strategy is urgently needed. We conducted prospective study of 23 (median age, 68 years; range, 60 to 87 years) newly diagnosed AML evaluate the efficacy toxicity decitabine plus granulocyte colony-stimulating factor priming, low-dose aclarubicin, cytarabine (DCAG) chemotherapy combined HLA-mismatched stem cell...
We retrospectively studied 87 patients aged from 55 to 69 years old with acute myeloid leukemia (AML) who received decitabine in combination G-CSF, low-dose cytarabine and aclarubicin (DCAG) or standard dose chemotherapy as induction therapy. Patients receiving DCAG had a similar overall response rate (ORR) (p = .6105) complete remission (CR) .3615) compared those undergoing induction. The median survival (OS) relapse-free (RFS) was also between the two groups although more ‘older’ (aged 60...
Cervical cancer (CC) is one of the most common gynecological malignancies in women worldwide.Recently, increasing evidence indicates aberrant expression miR-506, which was reported to be associated with a variety tumors.The aim this study evaluate potential role miR-506 CC and verify its effect on regulation ABCC4.The cervical tissues, HeLa C33A cell lines examined using quantitative Real-time PCR.MTT assay animals studies were used examine effects proliferation.Luciferase reporter western...
Abstract The present study aimed to explore brain morphological alterations associated with age and sex hormone levels between premenopausal perimenopausal women using magnetic resonance imaging ( MRI ) T 1 ‐weighted structural images. Thirty‐two aged (mean ± SD 47.75 1.55 years twenty‐five recently 51.60 1.63 were evaluated for levels, including prolactin, follicle‐stimulating hormone, luteinising oestradiol, free testosterone progesterone. A 3.0‐Tesla scanner was utilised acquire...
Lithium hexafluorophosphate (LiPF6) is one of the leading electrolytes in lithium-ion batteries, and its usage has increased tremendously past few years. Little known, however, about potential environmental biological impacts. In order to improve our understanding cytotoxicity LiPF6 specific cellular response mechanisms it, we performed a genome-wide screen using yeast (Saccharomyces cerevisiae) deletion mutant collection identified 75 gene mutants that showed sensitivity. Among these, genes...
There have been no reports about the application of random survival forest (RSF) model to predict disease progression HIV-associated B-cell lymphoma.
Breast cancer-related lymphedema (BCRL) has a notable impact on patients' quality of life. However, no instrument is available to assess the problems in functioning due BCRL China.The aims this study were translate and validate Chinese version Lymphedema Functioning, Disability, Health Questionnaire for Upper Limb (Lymph-ICF-UL).A process translation cultural adaptation was conducted based international standards. The included 155 patients with 90 without lymphedema. Psychometric properties...