A5100750526- Pharmacological Effects of Natural Compounds
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Polysaccharides and Plant Cell Walls
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Reproductive System and Pregnancy
- Bee Products Chemical Analysis
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Andrographolide Research and Applications
- Natural product bioactivities and synthesis
- Saffron Plant Research Studies
- Endometriosis Research and Treatment
- Genomic variations and chromosomal abnormalities
- Microencapsulation and Drying Processes
- Biological and pharmacological studies of plants
- Advanced Cellulose Research Studies
- Advancements in Transdermal Drug Delivery
- Natural Products and Biological Research
- Ziziphus Jujuba Studies and Applications
- Proteins in Food Systems
- Glycosylation and Glycoproteins Research
- Drug Transport and Resistance Mechanisms
- Nigella sativa pharmacological applications
Jiangxi University of Traditional Chinese Medicine
2014-2024
Nanjing University of Chinese Medicine
2019-2024
Tianjin Medical University
2024
Second Hospital of Tianjin Medical University
2024
Dalian Medical University
2023
Wenzhou Medical University
2023
Zhejiang Taizhou Hospital
2023
Jilin University
2023
Institute of High Performance Computing
2023
Agency for Science, Technology and Research
2023
The chemical composition of many essential oils indicates that they have sedative and hypnotic effects, but there is still a lack systematic studies on the effects oils. In addition, aromatherapy does not seem to side traditional psychotropic substances, which clearly worthwhile for further clinical scientific research. application in has received increasing attention, detailed pharmacological activities inhaled are increasingly needed.As insomniacs usually accompanied by symptoms depression...
Circular RNAs (circRNA) play key regulatory roles in cancer progression. Human circRNA microarray was performed to screen for abnormally expressed gastric tissues. In this study, we found circRNA102958 up-regulated tissues and cell lines.The hsa_circRNA_102958 levels were detected by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) tissue cell. Then, the association between expression level of clinicopathological features patients with further analyzed. Finally, a...
Objectives Inflammatory cytokines (ICs) play an important role in erectile dysfunction (ED). Previous studies have demonstrated that most ED patients high levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8). The causality between 41 ICs is investigated using the Mendelian randomization (MR) approach. Methods Single nucleotide polymorphisms (SNPs) exposure data came from a genome-wide association study (GWAS) 8293 subjects. At same time, FINNGEN R9...
Nose-to-brain drug delivery is an effective approach for poorly soluble drugs to bypass the blood-brain barrier. A new intranasal system, a nanosuspension-based in situ gel, was developed and evaluated improve solubility bioavailability of prolong its retention time nasal cavity.Breviscapine (BRE) chosen as model drug. BRE nanosuspensions (BRE-NS) were converted into nanosuspension powders (BRE-NP). gelling system (BRE-NG) prepared by mixing BRE-NP 0.5% gellan gum (m/v). First, terms...
The active component-target network and protein-protein interaction of Compound Anshen essential oil were constructed. target functions related pathways analyzed to explore the mechanism in treatment insomnia. GC-MS was used detect chemical composition oil, TCMSP, STITCH, TTD, DrugBank databases searched predict screen targets Cytoscape software construct diagrams component-action networks, ClueGO analyze GO enrichment KEGG pathway target, systemsDock website database for molecular docking....
Abstract Main objectives of this work were to investigate the influences ultrasound pretreatment (UP) and microwave (MP) on extraction kinetics, chemical composition, antioxidant activity Kumquat peel essential oil (EO) obtained by hydrodistillation (HDE). The effects power processing time, time evaluated. As compared with HDE individually, UP MP decreased increased yield DPPH radical‐scavenging but did not noticeably affect composition EO. For MP, highest EO was when ultrasonic 210 W 30...
Multiple gastrointestinal barriers (mucus clearance and epithelium barrier) are the main challenges in oral administration of nanocarriers. To achieve efficient mucus penetration epithelial absorption, a novel strategy based on mesoporous silica nanoparticles with dendritic superstructure, hydrophilicity, nearly neutral-charged modification was designed. The mPEG covalently grafted (mPEG-DMSNs) had particle size about 200 nm loading capacity up to 50% andrographolide (AG) as nanocrystal...
This study is aimed at seeking a nature saponin-based stabilizer for drug nanosuspensions. A poorly soluble (baicalein, BCL) was used as model drug. BCL nanosuspensions with particle size of 156 nm were prepared by means homogenization and converted into nanocrystals (BCL-NC) stabilized panax notoginseng saponins (PNS). It found that PNS able to prevent the aggregation BCL-NS during storage improve redispersibility BCL-NC after freeze-drying spray-drying, compared polymer PVPK30. The...
The objective of this study was to prepare and characterize geniposide-pharmcosomes (GP-PMS) optimize the process formulation variables using response surface methodology. Tetrahydrofuran used as a reaction medium, GP phospholipids were resolved into GP-PMS formed after organic solvent evaporated off under vacuum condition. optimized by central composite design (CCD) methodology (RSM). phospholipid-to-drug ratio (X1), temperature (X2) drug concentration (X3) selected independent yield (%)...
Abstract Background Endometriosis (EMS) occurs when normal uterine tissue grows outside the uterus and causes chronic pelvic pain infertility. Endometriosis-associated infertility is thought to be caused by unknown mechanisms. In this study, using necroptosis-related genes, we developed validated multigene joint signatures diagnose EMS explored their biological roles. Methods We downloaded two databases (GSE7305 GSE1169) from Gene Expression Omnibus (GEO) database 630 genes GeneCards GSEA...
There have been no reports about the application of random survival forest (RSF) model to predict disease progression HIV-associated B-cell lymphoma.