A5103274417- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Hormonal and reproductive studies
- Circular RNAs in diseases
- Kidney Stones and Urolithiasis Treatments
- MicroRNA in disease regulation
- Urinary Bladder and Prostate Research
- Diagnosis and treatment of tuberculosis
- Pediatric Urology and Nephrology Studies
- Mechanisms of cancer metastasis
- Cancer Mechanisms and Therapy
- RNA Research and Splicing
- Sexuality, Behavior, and Technology
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Biomedical Research and Pathophysiology
- Immunotherapy and Immune Responses
- Renal cell carcinoma treatment
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- Colorectal Cancer Surgical Treatments
- Infectious Disease Case Reports and Treatments
Second Hospital of Tianjin Medical University
2012-2024
Tianjin Medical University
2012-2024
Background: Clear cell renal carcinoma (ccRCC) accounts for 80% of all kidney cancers and has a poor prognosis. Recent studies have shown that copper-dependent, regulated death differs from previously known mechanisms (apoptosis, ferroptosis, necroptosis) is dependent on mitochondrial respiration (Tsvetkov et al., Science, 2022, 375 (6586), 1254-1261). Studies also suggested targeting cuproptosis may be novel therapeutic strategy cancer therapy. In ccRCC, both lncRNA were critical, but the...
Objectives Inflammatory cytokines (ICs) play an important role in erectile dysfunction (ED). Previous studies have demonstrated that most ED patients high levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8). The causality between 41 ICs is investigated using the Mendelian randomization (MR) approach. Methods Single nucleotide polymorphisms (SNPs) exposure data came from a genome-wide association study (GWAS) 8293 subjects. At same time, FINNGEN R9...
Oxidative stress is a causal factor and key promoter of urolithiasis associated with renal tubular epithelium cell injury. The present study was designed to investigate the preventive effects metformin on injury induced by oxalate stone formation in hyperoxaluric rat model. MTT assays were carried out determine protection from oxalate‐induced cytotoxicity. intracellular superoxide dismutase (SOD) activities malondialdehyde (MDA) levels measured vitro. Male Sprague‐Dawley rats divided into...
Although we and other studies indicated ZNF217 expression was increased in prostate cancer (PCa), the factors mediating its misregulated their oncogenic activity remain largely unexplored. Recent evidence demonstrated that ferroportin (FPN) reduction lead to decreased iron export intercellular consequently aggravates effects of iron. In present study, identified as a transcriptional repressor inhibits FPN expression. Increased led concentration, coupled with resultant intracellular...
Patients diagnosed with prostate cancer often have a poor prognosis and limited treatment options, as the specific pathogenesis remains to be elucidated. Circular RNA (circRNA) is type of non-coding that interacts microRNA (miRNA/miR) transcription factors regulate gene expression. However, little known about circRNAs serve roles in cancer. Findings present study confirmed circRNA G protein subunit γ 4 (circGNG4) was upregulated tissues cell lines. Knockdown circGNG4 inhibited malignant...
The N-myc downstream-regulated gene 1 (NDRG1) has been discovered as a significant in the progression of cancers. However, regulatory mechanism NDRG1 remained obscure prostate cancer (PCa).The miR-96-5p and expression levels were evaluated PCa cell lines, tissues, validated public databases by real-time PCR, western blot analysis, immunohistochemistry. function investigated wound healing transwell assays vitro, mouse xenograft assay vivo. candidate pathway regulated was conducted...
CHMP4C is one of the charged multivesicular protein (CHMP), and involved in composition endosomal sorting complex required for transport III (ESCRT-III), facilitating necessary separation daughter cells. has been proposed to be progression different carcinomas. However, value prostate cancer not yet explored. Prostate most frequently occurring malignancy among male remains a leading cause deaths cancers. So far, clinical therapy more inclined molecular classification specific treatment...
Background In reference to previous studies, necroptosis played an important role in cancer development. Our team decided explore the potential prognostic values of long non-coding RNAs (lncRNAs) associated with bladder urothelial carcinoma (BLCA) and their relationship tumor microenvironment (TME) immunotherapeutic response for accurate dose. Methods To obtain required data, transcriptome data were searched from Cancer Genome Atlas (TCGA) ( https://portal.gdc.cancer.gov/ ). We used...
Abstract Objective To estimate the prognostic value of positive surgical margins (PSM) location and perineural invasion (PNI) for biochemical recurrence (BCR) in patients undergoing radical prostatectomy (RP). Methods All men with prostate cancer (PCa) who received RP second hospital Tianjin Medical University from 2014 to 2018 were retrospectively identified. met following criteria: no neoadjuvant or adjuvant treatment, absence lymph node invasion, distant metastasis confirmed by surgery...
Prostate cancer ranks among the six most lethal malignancies worldwide. Telomerase, a reverse transcriptase enzyme, plays pivotal role in extending cellular telomeres and is intimately associated with cell proliferation division. However, interconnection between prostate telomerase-related genes (TEASEs) remains unclear.
Loss of miR-516a-3p mediates upregulation ABCC5 in prostate cancer and drives its progression Hongtuan Zhang, Zhenpeng Lian, Guangyu Sun, Ranlu Liu, Yong Xu Department Urology, National Key Specialty The Second Hospital Tianjin Medical University, Institute Tianjin, China Abstract: To gain a comprehensive understanding whether can regulate (PCa) progression, we performed microarray data analyses identified that was drastically increased primary PCa relative to normal samples, metastatic PCa,...
To evaluate the clinical efficacy, safety, and costs of percutaneous occlusive balloon catheter-assisted ureteroscopic lithotripsy (POBC-URSL) for large impacted proximal ureteral calculi.156 patients with stones ≥1.5 cm in size were randomized to (URSL), POBC-URSL, nephrolithotomy (PNL) group between May 2010 2013. For URSL, calculi disintegrated assistance anti-retropulsion devices. POBC-URSL was performed an 8F catheter. PNL finished combination ultrasonic a pneumatic lithotripter. A...
Background: Type X collagen (COL10) is a homologous trimeric non-fibrillar found in the extracellular matrix of human tissues, and it exhibits distinctive white appearance. α1 chain (COL10A1) specific cleaved fragment type collagen. However, expression, prognostic significance, clinicopathological attributes immune-related associations COL10A1 prostate cancer as well pan-cancer contexts remain poorly understood. Methods: Using bioinformatic analysis data from most recent databases (TCGA,...
Abstract Objectives Anoikis plays an active role in the metastasis and progression of many tumors is emerging as a new target for tumor therapy. We aimed to develop anoikis-related risk model assess prognosis patients with bladder urothelial carcinoma (BLCA) explore its potential application value immunotherapy. Methods Patient expression data clinical were obtained from GEO TCGA database. Lasso regression was used obtain efficacy evaluated Cox regression, calibration curves, nomogram...