A5100343295- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Ureteral procedures and complications
- Therapeutic Uses of Natural Elements
- Urinary Tract Infections Management
- Paleopathology and ancient diseases
- Magnesium in Health and Disease
- Renal and Vascular Pathologies
- Parathyroid Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Digestive system and related health
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Dialysis and Renal Disease Management
- Healthcare and Venom Research
- Urinary Bladder and Prostate Research
- Immune responses and vaccinations
- Metabolomics and Mass Spectrometry Studies
- Advanced Technologies in Various Fields
- Biomedical Research and Pathophysiology
- Glutathione Transferases and Polymorphisms
- Cancer Mechanisms and Therapy
- Radioactive element chemistry and processing
- Alcohol Consumption and Health Effects
- Artificial Intelligence in Healthcare and Education
Tianjin Medical University
2011-2025
Second Hospital of Tianjin Medical University
2011-2025
Tianjin University of Technology
2025
Shandong Youth University of Political Science
2024
Abstract The pathogenesis of renal calcium-oxalate (CaOx) stones is complex and influenced by various metabolic factors. In parallel, palmitic acid (PA) has been identified as an upregulated lipid metabolite in the urine serum patients with CaOx via untargeted metabolomics. Thus, this study aimed to mechanistically assess whether PA involved stone formation. Lipidomics analysis PA-treated tubular epithelial cells compared control samples revealed that α-linoleic α-linolenic were desaturated...
Abstract During the formation of kidney stones, interaction between crystals and tubular epithelial cells (TECs) leads to injury dysfunction, which in turn promote stone formation. However, molecular mechanisms underlying these changes TECs remain elusive. Drug screening revealed that JQ1 inhibited adhesion calcium oxalate (CaOx) TECs. Its therapeutic effect is further confirmed a glyoxylic acid‐induced CaOx crystal deposition mouse model. Utilizing epigenomic transcriptomic profiling,...
Oxidative stress is a causal factor and key promoter of urolithiasis associated with renal tubular epithelium cell injury. The present study was designed to investigate the preventive effects metformin on injury induced by oxalate stone formation in hyperoxaluric rat model. MTT assays were carried out determine protection from oxalate‐induced cytotoxicity. intracellular superoxide dismutase (SOD) activities malondialdehyde (MDA) levels measured vitro. Male Sprague‐Dawley rats divided into...
CCR2 (C-C chemokine receptor type 2) is a monocyte associated with oxidative stress and inflammation. Kidney stones (KS) are composed of calcium oxalate (CaOx), which trigger renal inflammatory. This study aims to evaluate the effects on KS in vivo vitro. Eight-week-old male C57BL/6J mice were intraperitoneally injected glyoxylate (GOX) daily establish model, along antagonist (INCB3344) treatment days 2, 4, 6. The results showed that reduced injury markers (blood urea nitrogen serum...
To report our initial experience using a self-made optical system to visually identify the quality of chosen access before operating tract dilation.We retrospectively reviewed data on patients with renal stones treated by percutaneous nephrolithotomy (PCNL) in hospital. The were divided into Groups A and B, according those who received treatment visual PCNL conventional modalities, respectively. Based degree hydronephrosis, each group further two subgroups, mild hydronephrosis (subgroup 1)...
Treatment targeting osteopontin (OPN) and monocyte chemoattractant protein 1 (MCP‑1) has been recognized as a novel approach in renal crystal formation. The present study was designed to investigate the suppressive effects of metformin on nephrolithiasis formation its potential mechanism. cytotoxicity MDCK HK‑2 cells determined using Cell Counting Kit‑8 assay vitro. Subsequently, mRNA transcription expression levels MCP‑1 OPN were detected by reverse transcription‑quantitative‑polymerase...
BackgroundPercutaneous nephrolithotomy (PCNL) is thought to have an increased risk of infectious complications. This study evaluates the predictability preoperative midstream urine culture (PMUC), stone (SC), and renal pelvis (RPUC) for post-PCNL systemic inflammatory response syndrome (SIRS) or urosepsis.MethodAfter literature search in electronic databases (Embase, PubMed, Ovid, Science Direct, Springer), studies were selected by following precise eligibility criteria. The quality included...
Abstract Background To evaluate the incidence of metabolic syndrome (MetS) in patients with unilateral and bilateral staghorn calculi (SC) impact on outcome percutaneous nephrolithotomy (PCNL). Methods The clinical data who underwent PCNL for treatment SC between 2019 2022 were retrospectively reviewed. was divided into bilateral. MetS compared SC, assessed. Results A total 1778 2022. After screening computed tomography, 379 confirmed to have finally, leaving 310 follow-up complete be...
Calcium oxalate (CaOx) kidney stones pose a global health challenge due to their high prevalence and recurrence rates. While cell death mechanisms such as ferroptosis are known play crucial role in stone formation, the precise underlying remain enigmatic. Aldehyde dehydrogenase 2 (ALDH2) is metabolic enzyme of product 4-hydroxy-2-nonenal (4-HNE). However, function ALDH2 poorly understood. In this study, we observed downregulation group. Significantly, administration Alda-1, an agonist,...
Purpose As a rare bladder tumor, paraganglioma of the urinary (PUB) is frequently misdiagnosed as cancer, particularly for non-functional type. To date, transurethral resection remains controversial treatment PUB. This study aimed to identify clinical features, pathological characteristics, prognosis, and safe/effective PUB using tumor (TURBT). Materials Methods The records, radiological data, characteristics follow-up times were retrospectively reviewed in 10 patients with clinically...
Among men, prostate cancer (PCa) is one of the most commonly diagnosed cancers and leading cause death worldwide. Phosphatase tension homolog (PTEN) acts as a negative regulator phosphatidylinositol 3-kinase (PIK3)/Akt pathway suppresses tumor progression. Meanwhile, PTEN frequently deleted in PCa. Identifying specific molecular markers biochemical recurrence (BCR) PCa patients critical clinical practice. Our systematic review summarizes evidence about expression BCR rate patients.To clarify...
Abstract Calcium oxalate (CaOx) kidney stones pose a global health challenge due to their high prevalence and recurrence rates. While cell death mechanisms such as ferroptosis are known play crucial role in stone formation, the precise underlying remain enigmatic. Aldehyde dehydrogenase 2 (ALDH2) is metabolic enzyme of product 4-hydroxy-2-nonenal (4-HNE). However, function ALDH2 poorly understood. In this study, expression was assessed tissues HK-2 cells using immunohistochemistry western...
<title>Abstract</title> <bold>Objective:</bold> Construction and validation of a dynamic online nomogram for failed ureteral access sheath (UAS) placement during retrograde intrarenal surgery (RIRS) in patients with stones. <bold>Methods:</bold> This study retrospectively gathered medical records stone data from undergoing stones at the Department Urology, Second Hospital Tianjin Medical University, between January December 2022. Lasso combined logistic regression was utilized to identify...