A5100428300- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Metastasis and carcinoma case studies
- Kidney Stones and Urolithiasis Treatments
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Medical Imaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Phytoestrogen effects and research
- Pediatric Urology and Nephrology Studies
- Advanced Glycation End Products research
- Lung Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chronic Lymphocytic Leukemia Research
- Parathyroid Disorders and Treatments
- Therapeutic Uses of Natural Elements
- Polyomavirus and related diseases
- Traditional Chinese Medicine Studies
- Pressure Ulcer Prevention and Management
- Cardiovascular Function and Risk Factors
- Cystic Fibrosis Research Advances
Capital Medical University
2025
Peking University
2008-2023
Peking University Cancer Hospital
2008-2023
Tianjin Medical University
2011-2023
First Affiliated Hospital of Gannan Medical University
2023
Chinese PLA General Hospital
2015-2023
Tianjin Anding Hospital
2023
Zaozhuang Municipal Hospital
2022
Second Hospital of Tianjin Medical University
2011-2022
Guangzhou University of Chinese Medicine
2022
Abstract Background The triglyceride–glucose (TyG) index is increasingly recognized for its ability to predict cardiovascular and metabolic risks. This study investigated the correlation between TyG risk of acute kidney injury(AKI) in critical ill patients with pancreatitis(AP). Methods Medical Information Mart Intensive Care IV database was retrospectively searched identify AP hospitalized intensive care unit. primary outcome measure incidence AKI. secondary endpoint in-hospital mortality...
In phase 3 trials, delayed-release dimethyl fumarate (DMF; also known as gastroresistant DMF) demonstrated efficacy in relapsing-remitting multiple sclerosis (MS). Gastrointestinal (GI) events were associated with DMF treatment. The single-arm, open-label MANAGE study examined the incidence, severity, duration, and management of GI adults relapsing MS initiating treatment clinical practice United States shortly after marketing approval.Patients (N = 233) took for up to 12 weeks recorded...
Abstract Purpose This phase 1 trial evaluated the safety, preliminary efficacy, and pharmacokinetics of surufatinib, a small molecular tyrosine kinase inhibitor, combined with toripalimab, programmed cell death protein-1 antibody, in patients advanced solid tumors. Methods is an open-label, dose-escalation expansion study tumors who had failed standard therapies or no effective treatment. In stage, were treated at dose levels 200, 250, 300 mg once daily (QD) combination toripalimab 240 mg,...
Background . p38 mitogen-activated protein kinase (MAPK) plays a crucial role in regulating signaling pathways implicated inflammatory processes leading to diabetic nephropathy (DN). This study aimed examine MAPK activation DN and determine whether beraprost sodium (BPS) ameliorates by inhibiting inflammation pathway rats. Methods Forty male Sprague Dawley (SD) rats were randomly divided into the normal control group, type 2 BPS treatment group. At end of 8-week experiment, we measured renal...
Delayed-release dimethyl fumarate (DMF) has demonstrated efficacy and a favorable benefit-risk profile in phase 2 3 studies that enrolled predominantly white patients with relapsing-remitting multiple sclerosis (RRMS). In this study (APEX, Part I), we evaluated the efficacy/safety outcomes of DMF East Asian population RRMS. 24-week, randomized, double-blind, placebo-controlled study, 225 patients, 142 which were (63.4%), enrolled: Japan (n = 114), South Korea 20), Taiwan 8), Czech Republic...
Abstract Aim Pyrotinib (an irreversible pan‐ErbB small‐molecular tyrosine kinase inhibitor) was approved in human epidermal growth factor receptor 2 (HER2)‐positive breast cancer and showed great antitumor activity preclinical studies of gastric (GC). This study first designed to prospectively assess pyrotinib pretreated HER2‐positive GC. Methods multicenter, phase I followed a standard “3 + 3” design included two parts. In the part, administered orally, once per day at dose levels 240, 320,...
Squamous cell carcinoma (SCC) and melanoma are malignant human cancers of the skin with an annual mortality that exceeds 10,000 cases every year in USA alone. In this study, lysosomal protein saposin C (SapC) phospholipid dioloylphosphatidylserine (DOPS) were assembled into cancer-selective nanovesicles (SapC-DOPS) successfully tested using several vitro vivo cancer models. Using MTT assay measures percentage death, SapC-DOPS cytotoxic effect on three tumor lines (squamous carcinoma,...
Background: Grading based on histopathologic indicators cannot accurately assess the prognosis of phyllodes tumor (PT) breast. This article aimed to investigate correlation between PT and clinicopathological features, treatment, surgical margin. Methods: The data patients with pathologically confirmed at our institution were retrospectively collected. Univariate multivariate Cox proportional risk models employed test effects different variables PT. A nomogram predict 1-, 3-, 5-, 10-year...
Diabetic nephropathy (DN) is one of the most serious and dangerous chronic complications diabetes mellitus.Panax notoginseng has been widely used with great efficacy in long-term treatment kidney disease. However, mechanism by which it exerts its effects not fully elucidated.We sought to identify major components ofPanax that are effective reducing symptoms DN vitro vivo.Inhibition cell proliferation collagen secretion were screen ten highly concentrated notoginseng. The STZ-induced rat...
Treatment targeting osteopontin (OPN) and monocyte chemoattractant protein 1 (MCP‑1) has been recognized as a novel approach in renal crystal formation. The present study was designed to investigate the suppressive effects of metformin on nephrolithiasis formation its potential mechanism. cytotoxicity MDCK HK‑2 cells determined using Cell Counting Kit‑8 assay vitro. Subsequently, mRNA transcription expression levels MCP‑1 OPN were detected by reverse transcription‑quantitative‑polymerase...
To compare the effect of managing neonatal lung disease with ultrasound (LUS) or chest X-ray (CXR) monitoring on health outcomes and cost-effectiveness.The data obtained from NICU Beijing Chaoyang District Maternal Child Healthcare Hospital were used as study group, LUS has completely replaced CXR in newborn hospital for past 5 years. The primary this misdiagnosis rate respiratory distress syndrome (RDS), using status mechanical ventilation, incidence bronchopulmonary dysplasia (BPD)...
Introduction: Non-Hodgkin lymphoma (NHL) has a much higher incidence rate than Hodgkin lymphoma. Approximately 40% NHL occurs in extranodal tissues or organs, and its clinical manifestations are often nonspecific. Primary bone involving the mandible is an uncommon that characterized by fever, gum swelling toothache. Therefore, it misdiagnosed as oral diseases. Case Presentation: A 52-year-old female had recurrent fever for more 1 month, with numbness her left jaw PET/CT showed uptake area...
BACKGROUND Splenic marginal zone lymphomas (SMZLs) are generally uncommon, indolent that typically affect older adults, but the development of transformation to high-grade lymphoma may occur in a small proportion patients and represents rare event with blastic cell infiltration lymph nodes bone marrow. CASE REPORT Here, we present young adult patient who was diagnosed SMZL developed diffuse large B (DLBCL) central nervous system involvement. The 31-year-old woman whose hematologic medical...
The metabolic differences between patients with calcium oxalate (CaOx) urolithiasis and the healthy population remain unclear. Currently there is no diagnostic panel for CaOx urolithiasis. This study aimed to identify full-scale changes in urine of establish a novel as noninvasive early prevention method. 240 samples were collected from 137 diagnosed 103 controls. Electrospray ionization – mass spectrometry (ESI-MS) metabolomics univariate, multivariate, bioinformatic analyses combined...