A5064175839- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Ultrasound in Clinical Applications
- Crystallography and molecular interactions
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Pleural and Pulmonary Diseases
- Atomic and Subatomic Physics Research
- Phonocardiography and Auscultation Techniques
- Respiratory Support and Mechanisms
- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Muscle and Compartmental Disorders
- Sirtuins and Resveratrol in Medicine
- Autoimmune and Inflammatory Disorders Research
- Cancer-related gene regulation
- Cardiovascular Function and Risk Factors
- Cardiovascular and Diving-Related Complications
- Natural Products and Biological Research
- Wnt/β-catenin signaling in development and cancer
- Free Radicals and Antioxidants
- Supramolecular Self-Assembly in Materials
- Renal function and acid-base balance
- HIV, Drug Use, Sexual Risk
Capital Medical University
2022-2025
Beijing Obstetrics and Gynecology Hospital
2023-2025
Beijing Chao-Yang Hospital
2022-2023
Southern Medical University
2022
West China Hospital of Sichuan University
2021
University of Chinese Academy of Sciences
2021
Center for Excellence in Molecular Cell Science
2021
Chinese Academy of Sciences
2021
Institute of Hematology & Blood Diseases Hospital
2021
National Clinical Research
2021
Lung ultrasound (LUS) is now widely used in the diagnosis and monitor of neonatal lung diseases. Nevertheless, published literatures, LUS images may display a significant variation technical execution, while scanning parameters influence diagnostic accuracy. The inter- intra-observer reliabilities exam have been extensively studied general LUS. As expected, reliability declines hands novices when they perform point-of-care (POC US). Consequently, having appropriate guidelines regarding to...
Significance Receptor-interacting protein kinases 3 (RIPK3), a hub player in necrotic cell death, forms amyloid-like polymers response to upstream mediators. This work, by using cryo-EM and solid-state NMR, reports the structure of human RIPK3 amyloid fibril core. The core is mainly composed consensus RHIM domain exhibits distinctive properties: an exceptionally small existence both handedness. These traits may provide favorable geometry for arrangement kinase on surface boost...
Background: Respiratory distress syndrome (RDS) is a common critical lung disease in newborn infants, especially those premature infants with higher mortality rate. Early and correct diagnosis the key to improve its prognosis. Previously, of RDS mainly relied on chest X-ray (CXR) findings, it has been graded into four stages based progression severity CXR changes. This traditional diagnosing grading method may lead high misdiagnosis rate or delayed diagnosis. Recently, using ultrasound...
Objective This study aimed to evaluate the application of ultrasound for localization tip position peripherally inserted central catheters (PICCs) in newborn infants. Study Design was a retrospective analysis on ultrasonic PICC placement conducted our department over past 2 years. Ultrasonic performed immediately after all neonatal patients. Successful confirmed if located at inferior/superior cavoatrial junction. Chest X-ray 32 infants examination compare accuracy localization. Results Of...
Typical hydrophobic amino acids (HAAs) are important motifs for self-assembling peptides (SAPs), but they lead to low water-solubility or compact packing of peptides, limiting their capacity encapsulating drugs. As an alternative, we designed a peptide GQY based on atypical HAAs, which could encapsulate drugs more efficiently. Although general anesthetics (GAs) have been formulated as lipid emulsions, lipid-free formulations pursued because some side effects inherent lipids. Using GAs...
Abstract Objective The aim of this study was to investigate the efficacy and safety bronchoalveolar lavage (BAL) in treatment neonatal severe pneumonia (NSP). Methods One hundred patients with were randomly divided into two groups, BAL control 50 each group. In group, normal saline instilled endotracheal tube for BAL. Before after lavage, lung ultrasound (LUS) monitoring performed observe pathological changes. Conventional administered need duration invasive mechanical ventilation,...
Abstract BACKGROUND Astaxanthin (Asta) is widely used in the nutraceutical and food industry because of its strong antioxidant properties. However, natural Asta mainly exists esterified form with various fatty acid chains, making it difficult to understand particular molecular structure astaxanthin esters (Asta‐Es) that have better capacity. In this study, Asta‐Es different structures was systematically prepared, identified by using thin‐layer chromatography (TLC), ultraviolet‐visible...
With the improvement in survival rates of low-birthweight and very premature infants, neonatal fungal infection, especially pneumonia, is becoming more common, but diagnosis always challenging. Recently, lung ultrasound (LUS) has been used to diagnose pneumonia newborn not pneumonia. This paper summarizes ultrasonographic features seven cases such as consolidation with air bronchograms, shred signs, pulse, pleural line abnormalities, different kinds B-lines. It was confirmed that LUS plays...
Abstract BACKGROUND Previous data, although scant, indicated that the incidence of HIV in China has increased over past decade. There is a growing concern about impact epidemic on blood safety. METHODS AND MATERIALS We used donation data from five geographically‐disperse centers 2013‐2016 participating Recipient Epidemiology and Donor Evaluation Study‐III (REDS–III) program to estimate prevalence among donors. Multivariable logistic regression model was examine factors associated with...
Abstract Introduction Whether lung ultrasound (LUS) can be used for pathogenic diagnosis remains controversial. This study was conducted to clarify whether has diagnostic value etiology. Methods A total of 135 neonatal pneumonia patients with an identified pathogen were enrolled from the newborn intensive care units 10 tertiary hospitals in China. The ran November 2020 December 2021. infants divided into various groups according pathogens, time infection, gestational age, and disease...
To compare the effect of managing neonatal lung disease with ultrasound (LUS) or chest X-ray (CXR) monitoring on health outcomes and cost-effectiveness.The data obtained from NICU Beijing Chaoyang District Maternal Child Healthcare Hospital were used as study group, LUS has completely replaced CXR in newborn hospital for past 5 years. The primary this misdiagnosis rate respiratory distress syndrome (RDS), using status mechanical ventilation, incidence bronchopulmonary dysplasia (BPD)...
Purpose To determine the impact of flap creation methods for sub-Bowman’s keratomileusis (SBK) on central Bowman’s layer thickness. Methods SBK flaps were made by Moria microkeratome 20 subjects and femtosecond (FEMTO) laser 21 subjects. Corneal sublayer thicknesses measured ultra-high resolution optical coherence tomography before at 1 day, week, 2 weeks, month afterwards. Each subject was imaged twice each visit. Thicknesses epithelium, layer, flap, total cornea calculated using a...
Abstract Objective Capillary leak syndrome (CLS) is characterized by severe systemic edema without specific treatment, resulting in a high mortality rate. This study investigated whether there organ neonatal CLS patients and treatment strategies to improve patient prognosis. Methods Thirty-seven newborns diagnosed with were included this study. (1) Routine point-of-care ultrasound (POCUS) was used identify the had visceral or fluid collection. (2) All treated 3% NaCl intravenously, clinical...
Objective Pulmonary edema is the most common pathophysiological change in pulmonary disease. Aquaporins (AQPs) and Na+/K+-ATPase play pivotal roles alveolar fluid clearance. This study aimed to explore influence of increased on absorption lung fluid. Study Design Eighty New Zealand rabbits were randomly divided into eight groups (n = 10 each group), models different contents established by infusion volumes normal saline (NS) via endotracheal tube. Five animals group sacrificed immediately...
Capillary leak syndrome (CLS) is a rare, potentially life-threatening systemic disease with mortality rate of more than 30%. Its major clinical manifestation and diagnostic basis are hyperedema. However, we lack knowledge about the presence severe myocardial edema in patients CLS. If cannot be detected, it will become dangerous hidden condition that threatens safety patient lives. With routine application point-of-care critical ultrasound (POC-CUS) practice, found 2 37 (5.41%) CLS had as...
Point-of-care critical ultrasound (POC-CUS) screening plays an increasingly important role in the treatment of critically ill infants. Without POC-CUS, lives many infants would not be saved time and correctly. A premature infant with systemic multiple organ system dysfunction caused by fungal sepsis was treated nursed under guidance POC-CUS monitoring, ultimately cured. This had disseminated intravascular coagulation (DIC) sepsis. In hypercoagulable state early-stage DIC, cardiac thrombosis...
Background: Bronchopulmonary dysplasia (BPD) is a common severe respiratory problem in premature infants, and imaging information has important reference value for its diagnosis. Recently, lung ultrasonography (LUS) been successfully used the diagnosis differential of neonatal diseases (NLDs), but study BPD still rare. Objectives: The purpose this was to investigate ultrasonographic characteristics infants’ BPD. Methods: From January 2015 December 2019, 25 infants diagnosed with early-stage...