A5101666971- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- Ultrasound in Clinical Applications
- Nosocomial Infections in ICU
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Clinical Nutrition and Gastroenterology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Nutrition and Health in Aging
- Immune cells in cancer
- Child Nutrition and Feeding Issues
- Climate Change and Health Impacts
- Renal function and acid-base balance
- Thermal Regulation in Medicine
- Family and Patient Care in Intensive Care Units
- Clinical Reasoning and Diagnostic Skills
- Inflammatory Biomarkers in Disease Prognosis
- Inflammation biomarkers and pathways
- Adrenal Hormones and Disorders
- Biomarkers in Disease Mechanisms
- Ureteral procedures and complications
- Plant Pathogens and Fungal Diseases
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
Zhejiang University
2022-2024
Zhejiang Hospital
2014-2024
Jinhua Central Hospital
2017
Women's Hospital, School of Medicine, Zhejiang University
2015
Causal inference prevails in the field of laparoscopic surgery. Once causality between an intervention and outcome is established, can be applied to a target population improve clinical outcomes. In many scenarios, interventions are longitudinally response patients' conditions. Such longitudinal data comprise static variables, such as age, gender, comorbidities; dynamic treatment regime, laboratory vital signs. Some variables act both confounder mediator for effect on outcome; cases, simple...
Lung ultrasound (LUS) is now widely used in the diagnosis and monitor of neonatal lung diseases. Nevertheless, published literatures, LUS images may display a significant variation technical execution, while scanning parameters influence diagnostic accuracy. The inter- intra-observer reliabilities exam have been extensively studied general LUS. As expected, reliability declines hands novices when they perform point-of-care (POC US). Consequently, having appropriate guidelines regarding to...
Septic shock is characterized by an uncontrolled inflammatory response and microcirculatory dysfunction. There currently no specific agent for treating septic shock. Anisodamine extracted from traditional Chinese medicine with potent anti-inflammatory effects. However, its clinical effectiveness remains largely unknown.In a multicentre, open-label trial, we randomly assigned adults to receive either usual care or anisodamine (0.1-0.5 mg per kilogram of body weight hour), the doses adjusted...
Objective: The aim of this study was to evaluate the diagnostic efficacy serum procalcitonin (PCT), c-reactive protein (CRP) concentration and clinical pulmonary infection score(CPIS) in ventilator-associated pneumonia(VAP). Methods: Forty-nine patients who were admitted intensive care unit (ICU) Zhejiang Hospital with suspected VAP recruited study. level PCT CRP all measured CPIS calculated at time diagnosis. Of included 49 patients, 24 finally confirmed by microbiology assay. And other 25...
Pneumothorax (PTX) represents accumulation of the air in pleural space. A large or tension pneumothorax can collapse lung and cause hemodynamic compromise, a life-threatening disorder. Traditionally, neonatal diagnosis has been based on clinical images, auscultation, transillumination, chest X-ray findings. This approach may potentially lead to delay both treatment. The use US PTX together with US-guided thoracentesis results earlier more precise management. recommendations presented this...
Abstract Background Left ventricular-arterial coupling (VAC), defined as the ratio of effective arterial elastance (Ea) to left ventricular end-systolic (Ees), has been extensively described a key determinant cardiovascular work efficacy. Previous studies indicated that uncoupling was associated with worse tissue perfusion and increased mortality in shock patients. Therefore, this study aims investigate whether resuscitation algorithm based on optimizing VAC during initial can improve...
Background Few studies have reported the effect of different volume responsiveness evaluation methods on therapy results and prognosis. This study was carried out to investigate two methods, stroke variation (SVV) changes before after passive leg raising (PLR-ΔSV), fluid resuscitation prognosis in septic shock patients. Methods Septic patients admitted Department Critical Care Medicine Zhejiang Hospital, China, from March 2011 2013, who were under controlled ventilation without arrhythmia,...
Abstract Objective The aim of this study was to investigate the diagnostic performance serum 1,3-β-D-gluan as biomarker for invasive fungal infection through meta-analysis. Methods electronic databases Medline, Cochrane, Embase, Web Science, OVID and CNKI were systematic searched identified case-control or Cohort studies relevant efficacy 1,3-β-D-glucan infection. data true positive (tp), false (fp), negative (fn) (tn) patients number extracted from each original included studies....
Abstract Background Acute respiratory distress syndrome (ARDS), a complex response to various insults, has high mortality rate. As pulmonary edema resulting from increased vascular permeability is hallmark of ARDS, management the fluid status, including urine output (UO) and intake (FI), essential. However, relationships between UO, FI, in ARDS remain unclear. This retrospective study aimed investigate interactive associations among ARDS. Methods was secondary analysis prospective randomized...
Abstract Lipopolysaccharide (LPS) could induce apoptosis and dysfunction of endothelial cells. We aimed to reveal the effects macrophages on cell proliferation in LPS induced human umbilical vein cells (HUVECs). THP-1 derived HUVECs were co-cultured presence LPS. Cell viability was measured by Counting Kit-8 analyzed flow cytometry. Expression Ang1, NF-κB component p65 evaluated western blot quantitative PCR. Small interfering RNAs (siRNAs) used knockdown expression proinflammatory cytokines...
Anemia is a risk factor for acute kidney injury (AKI) following cardiopulmonary bypass (CPB). Whether red blood cell (RBC) transfusion-enhanced hemoglobin levels contribute to low AKI rates remains unclear. We investigated the interaction between hemoglobin, RBC transfusion, and after CPB. Hemoglobin trajectories within 72 h were analyzed using group-based trajectory analysis. Multivariable logistic analysis inverse probability-weighted regression adopted evaluate associations in non-RBC...
Fluid balance (FB) is associated with poor sepsis outcomes; however, it cannot accurately reflect the dynamic fluid accumulation status. Here, we explored a new index, FB to intake ratio (FB/FI), for evaluating in sepsis. FB/FI values within 48 hours were recorded. Their association in-hospital mortality was investigated using logistic regression and mediation analyses of data from 7,839 patients. In extended models, linear found between (odds [OR]: 1.05-1.08, p < 0.001). However, this...
Surgical treatment of spinal hepatocellular carcinoma metastasis after Liver transplantation (LT) is a clinical challenge. We herein report the outcomes first case patient with T11 from systemic chemotherapy following LT combined mesenteric resection and colectomy, who was successfully treated En Bloc spondylectomy.The HCC 40-year-old man, had received colectomy 15 months before. His main symptom progressive back pain because metastasis. PET examinations showed solitary at without recurrence...
Coronavirus disease has heterogeneous clinical features; however, the reasons for heterogeneity are poorly understood. This study aimed to identify phenotypes according patients' temperature trajectory.A retrospective review was conducted in five tertiary hospitals Hubei Province from November 2019 March 2020. We explored potential temperature-based trajectory and assessed outcomes, inflammatory response, response immunotherapy phenotypes.A total of 1580 patients were included. Four...
Background: Few studies have reported the value of volume responsiveness evaluation on bioreactance-based passive leg raising (PLR) test in elderly patients.This study was carried out to determinate predictive PLR for predicting fluid (FR) patients with septic shock, and compare it central venous pressure (CVP). Methods: This prospective, single-centre enrolled 50 shock from Department Critical Care Medicine Zhejiang Hospital, Hangzhou, China, October 2012 2015. All underwent infusion...