A5032724127- Insect symbiosis and bacterial influences
- Genomics and Phylogenetic Studies
- Protist diversity and phylogeny
- Cancer-related molecular mechanisms research
- Invertebrate Immune Response Mechanisms
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Muscle and Compartmental Disorders
- Eicosanoids and Hypertension Pharmacology
- Aquaculture disease management and microbiota
- Circular RNAs in diseases
- Vascular Procedures and Complications
- Renal Diseases and Glomerulopathies
- Peroxisome Proliferator-Activated Receptors
- Genetic Syndromes and Imprinting
- Neurobiology and Insect Physiology Research
- Supramolecular Self-Assembly in Materials
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Ginseng Biological Effects and Applications
- Mesenchymal stem cell research
- IL-33, ST2, and ILC Pathways
- Acute Kidney Injury Research
- Mosquito-borne diseases and control
Second Affiliated Hospital of Zhejiang University
2018-2025
Zhejiang University
2014-2025
Peking University
2024-2025
State Key Laboratory of Natural and Biomimetic Drugs
2024-2025
University of Science and Technology of China
2016-2024
Hangzhou City University
2023-2024
State Key Laboratory of Silkworm Genomic Biology
2023
Southwest University
2023
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2022
Tianjin Institute of Pharmaceutical Research (China)
2022
Background & AimsWe aimed to identify long noncoding RNAs (lncRNAs) that are up-regulated in gastric cancer tissues from patients and study their function tumor metastasis.MethodsWe collected nontumor China analyzed levels of lncRNAs by microarray analysis, proteins immunohistochemistry, quantitative reverse-transcription polymerase chain reaction; we compared these with survival times progression. RNA were knocked down or out BGC-823, SGC-7901, MKN45 cell lines using small interfering short...
Sogatella furcifera is an important phloem sap-sucking and plant virus-transmitting migratory insect of rice. Because its high reproductive potential, dispersal capability transmission viral diseases, S. causes considerable damage to rice grain production has great economical agricultural impacts. Comprehensive studies into ecological aspects virus-host interactions have been limited because the lack a well-assembled genome sequence.A total 241.3 Gb raw reads from whole were generated by...
Gastric cancer (GC) is among the most lethal human malignancies, and leading cause of GC mortality metastasis. However, precise mechanism metastasis remains unclear. To screen key transcriptional factors (TFs) involved in metastasis, we performed bioinformatics analysis The Cancer Genome Atlas database found that Krüppel-like factor 9 (KLF9) a metastasis-associated TF. KLF9 significantly decreased patients with distant compared those without Ectopic expression evidently inhibited migration...
Although epigenetic modulation is critical for a variety of cellular activities, its role in erythropoiesis remains poorly understood. Ten-eleven translocation (TET) molecules participate methylcytosine (5mC) hydroxylation, which results DNA demethylation several biological processes. In this research, the TETs was investigated by using zebrafish model, where three TET homologs were identified. These share conserved structural domains with their mammalian counterparts. Zebrafish mediate...
Abstract The genetic basis of phenotypic variation is a long-standing concern evolutionary biology. Coloration has proven to be visual, easily quantifiable, and highly tractable system for analysis an ever-evolving focus biological research. Compared with the homogenized brown-yellow cocoons wild silkworms, domestic silkworms are spectacularly diverse in color, such as white, green, yellow-red; this provides outstanding model exploring diversification coloration. Herein, molecular mechanism...
Liver metastasis is a major cause of death in gastric cancer patients, but the underlying mechanisms are poorly understood. Through combination vivo screening and transcriptome profiling followed by quantitative RT-PCR tissue array analyses, we found that mitogen-activated protein kinase 4 (MAPK4) downregulation tissues from patients significantly associated with liver poor prognosis. The knockdown MAPK4 cells promotes orthotopic mouse models. depletion induces secretion macrophage migration...
Abstract Distant metastasis is the major cause of gastric cancer mortality, and epidermal growth factor receptor (EGFR) activation plays critical roles in dissemination. However, EGFR targeting therapies show only marginal effects, molecular mechanisms oncogenic signaling remain poorly defined. Here, we report Ephrin A1 as a novel ligand cancer. facilitates colonization cells vitro vivo via inducing epithelial-mesenchymal transition (EMT). directly interacts with induces dimerization,...
NAD(P)H:quinone oxidoreductase-1 (NQO1), a protein highly expressed in tumor cells, serves as an excellent trigger for releasing drugs specifically within cells. In this study, we designed activatable circular antisense oligonucleotide (cASO) by incorporating head-to-tail cyclization mediated NQO1-responsive trimethyl-locked quinone propionate (Q3PA), coupled with self-immolative linker. The resulting structure prevented the cASO from binding to target mRNA, thereby avoiding gene silencing....
Sogatella furcifera is a migratory pest that damages rice plants and causes severe economic losses. Due to its ability annually migrate long distances, S. has emerged as major of in several Asian countries. Symbiotic relationships inherited bacteria with terrestrial arthropods have significant implications. The genus Cardinium present many types arthropods, where it influences some host characteristics. We report newly identified strain the bacterial endosymbiont cSfur furcifera.From whole...
Gene therapy has been one of potential strategies for the treatment different diseases, where efficient and safe gene delivery systems are also extremely in need. Current lipid nanoparticles (LNP) technology highly depends on packing condensation nucleic acids with amine moieties. Here, an attempt to covalently link two natural compounds, spermine vitamin E, is made develop self-assembled acid systems. Among them, moieties specifically interact major groove siRNA helix through salt bridge...
Lin28, a highly conserved carcinogenic protein, plays an important role in the generation of cancer stem cells, contributing to unfavorable prognosis patients. This RNA binding protein specifically binds pri/pre-microRNA (miRNA) lethal-7 (let-7), impeding its miRNA maturation. The reduced expression tumor suppressor let-7 fosters development and progression-related traits such as proliferation, invasion, metastasis, drug resistance. We report series miRNA-based Lin28A-miRNA...
Abstract Sogatella furcifera , the white-backed planthopper (WBPH), has become one of most destructive pests in rice production owing to its plant sap-sucking behavior and efficient transmission Southern black-streaked dwarf virus (SRBSDV) a circulative, propagative persistent manner. The dynamic complex SRBSDV-WBPH-rice interaction is still poorly understood. In this study, based on homology-based genome-wide analysis, 348 immune-related genes belonging 28 families were identified WBPH. A...
Abstract The genome‐wide characterization of long non‐coding RNA (lncRNA) in insects demonstrates their importance fundamental biological processes. Essentially, an in‐depth understanding the functional repertoire lncRNA is pivotal to insect resources utilization and sustainable pest control. Using a custom bioinformatics pipeline, we identified 1861 lncRNAs encoded by 1852 loci Sogatella furcifera genome. We profiled expression different developmental stages observed that more highly...
Abstract Single Ig IL-1R–related molecule (SIGIRR, also called IL-1R8 or Toll/IL-1R [TIR]8), a negative regulator for signaling, plays critical roles in innate immunity and various diseases mammals. However, the occurrence of this ancient vertebrates its function liver homeostasis disorders remain poorly understood. In study, we identified SIGIRR homology from zebrafish (Danio rerio [DrSIGIRR]) by using number conserved structural functional hallmarks to mammalian counterparts. DrSIGIRR was...
Abstract Scavenger receptor class A member 5 (SCARA5) and high-mobility group box 1 (HMGB1) protein have become increasingly attractive for their critical functions in innate inflammatory reactions disorders. However, the functional relevance between these two molecules has never been described. This study discovered that SCARA5 is an HMGB1 recognition negatively involved HMGB1-mediated inflammation pufferfish (Tetraodon nigroviridis) zebrafish (Danio rerio) models. Hence, added as a new to...
Patients with metastatic gastric cancer (GC) have a poor prognosis; however, the molecular mechanism of GC metastasis remains unclear. Here, we employed bioinformatics to systematically screen metastasis-associated genes and found that levels basal cell adhesion molecule (BCAM) were significantly increased in tissues from patients metastasis, as compared those without metastasis. The upregulation BCAM was also associated shorter survival time. Depletion inhibited migration invasion. Knockout...
Phenotypic plasticity is a common and highly adaptive phenomenon where the same genotype produces different phenotypes in response to environmental cues. Sogatella furcifera, migratory pest of rice exhibits wing dimorphism, model insect for studying phenotypic size. The Insullin-PI3K-Akt-FOXO signaling pathway plays crucial role manipulation size insects. However, regulatory mechanism via involved dimorphism are still unexplored.Accompanied by special alternative splicing, genes muscle...
CCL2-mediated macrophage infiltration in articular tissues plays a pivotal role the development of osteoarthritis (OA). miRNAs regulate onset and progression diseases via controlling expression series genes. How CCL2 gene was regulated by still not fully elucidated. In present study, we demonstrated that binding sites miR-33 3'UTR were conserved human, mouse rat species. By performing gain- or loss-of-function studies, verified suppressed mRNA protein levels. We also found levels supernatant...
Background Although sodium disturbances are common in hospitalised patients, no study has specifically investigated the epidemiology of hyponatraemia patients with crush syndrome. Objectives To describe incidence and assess its effect on outcome syndrome during Wenchuan earthquake. Methods A retrospective was conducted 17 reference hospitals We excluded younger than 15 years those missing values within 3 days after being rescued from ruins. Results Hyponatraemia (serum concentration <135...
ABSTRACT Cactin, a highly conserved protein, plays crucial role in various physiological processes eukaryotes, including innate immunity. Recently, the function of Cactin immunity Drosophila has been explored, revealing that regulates non-canonical signaling pathway associated with Toll and Imd pathways via Cactin-Deaf1 axis. In addition, exhibits specific antiviral activity against C virus (DCV) , an unknown mechanism. During DCV infection, it confirmed protein level are regulated by...
ABSTRACT RNA interference (RNAi) drives powerful antiviral immunity in plants and animals so that many viruses must express viral suppressor of RNAi (VSR) to establish virulent infection. However, little is known about the immune responses conferring resistance against have evolved counter-defensive strategy suppress RNAi. In this study, we discover Drosophila cells infected with C virus (DCV), a natural pathogen harbor potent VSR, exhibit heightened expression circular circZfh1. circZfh1...