A5100424513- Pancreatic function and diabetes
- Diabetes Management and Research
- Diabetes and associated disorders
- 3D Printing in Biomedical Research
- Metabolism, Diabetes, and Cancer
- Pluripotent Stem Cells Research
- Synthetic Organic Chemistry Methods
- Carbohydrate Chemistry and Synthesis
- Microfluidic and Capillary Electrophoresis Applications
- Spine and Intervertebral Disc Pathology
- Genetics and Neurodevelopmental Disorders
- Cannabis and Cannabinoid Research
- Mesenchymal stem cell research
- Diabetes Treatment and Management
- Orthopaedic implants and arthroplasty
- Cholangiocarcinoma and Gallbladder Cancer Studies
- PI3K/AKT/mTOR signaling in cancer
- Hip and Femur Fractures
- Reconstructive Surgery and Microvascular Techniques
- Phytoestrogen effects and research
- Tissue Engineering and Regenerative Medicine
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
Hainan Medical University
2025
University of Zurich
2023-2025
University Hospital of Zurich
2023-2025
TransUnion (United States)
2025
Huashan Hospital
2024-2025
Fudan University
2024-2025
Zhejiang Chinese Medical University
2023-2024
University of Virginia
2018-2024
Peking University Sixth Hospital
2024
Xi'an Jiaotong University
2024
Although previous studies have linked obesity to diabetes, the risks associated with weight gain or changes in body fat distribution not been fully elucidated. The authors therefore prospectively examined relations between and (1986–1996) subsequent risk of diabetes (1996–2000) among 22,171 men Health Professionals Follow-up Study. Weight was monotonically related risk, for every kilogram gained, increased by 7.3%. A abdominal positively independent change. Compared who had a stable waist,...
Transplantation of stem cell-derived β (SC-β) cells represents a promising therapy for type 1 diabetes (T1D). However, the delivery, maintenance, and retrieval these remain challenge. Here, we report design safe functional device composed highly porous, durable nanofibrous skin an immunoprotective hydrogel core. The consists electrospun medical-grade thermoplastic silicone-polycarbonate-urethane is soft but tough (~15 megapascal at rupture strain >2). Tuning nanofiber size to less than ~500...
This prospective phase 1/2 trial investigated the safety and reproducibility of allogeneic islet transplantation (Tx) in type I diabetic (T1DM) patients tested a strategy to achieve insulin-independence with lower mass. Ten C-peptide negative T1DM subjects hypoglycemic unawareness received 1–3 intraportal Tx were followed for 15 months. Four (Group 1) Edmonton immunosuppression regimen (daclizumab, sirolimus, tacrolimus). Six 2) University Illinois protocol (etanercept, exenatide regimen)....
The in vivo efficacy of many therapeutic peptides is hampered by their rapid proteolytic degradation. Cyclization these an excellent way to render them more resistant against breakdown. Here, we describe the enzymatic introduction a thioether ring angiotensin [Ang-(1-7)], heptapeptide that plays pivotal role renin-angiotensin system and possesses important activities. lactic acid bacterium <i>Lactococcus lactis</i>, equipped with plasmid-based nisin modification machinery, was used produce...
Attaining glycemic targets without severe hypoglycemic events (SHEs) is a challenging treatment goal for patients with type 1 diabetes complicated by impaired awareness of hypoglycemia (IAH). The CIT Consortium Protocol 07 (CIT-07) trial showed islet transplantation to be an effective subjects IAH and intractable SHEs. We evaluated health-related quality life (HRQOL), functional health status, utility before after pancreatic in CIT-07 participants.Four surveys, the Diabetes Distress Scale...
To design a hydrogel material containing nano hydroxyapatite particles for three-dimensional (3D) bio-printing and to explore whether can promote osteogenic differentiation of 3D construct consisting hASCs <italic>in vivo</italic> vitro</italic>.
The glucose-sensing enzyme glucokinase (GK) plays a key role in glucose metabolism. We report here the effects of novel activator, LY2121260. activator enhanced GK activity via binding to allosteric site located hinge region enzyme. LY2121260 stimulated insulin secretion glucose-dependent manner pancreatic beta-cells and increased use rat hepatocytes. In addition, incubation with resulted protein levels, suggesting that on chronic treatment may be due not only changed kinetics but also...
A microfluidic device to perfuse pancreatic islets while simultaneously characterizing their functionality through fluorescence imaging of the mitochondrial membrane potential and intracellular calcium ([Ca(2+)](i)) in addition enzyme linked immunosorbent assay (ELISA) quantification secreted insulin was developed characterized. This multimodal characterization islet function will facilitate rapid assessment tissue quality immediately following isolation from donor pancreas allow more...
Nitroimidazoles are a promising new class of antitubercular agents. The nitroimidazo-oxazole delamanid (OPC-67683, Deltyba) is in phase III trials for the treatment multidrug-resistant tuberculosis, while nitroimidazo-oxazine PA-824 entering drug-sensitive and drug-resistant tuberculosis. TBA-354 (SN31354[(S)-2-nitro-6-((6-(4-trifluoromethoxy)phenyl)pyridine-3-yl)methoxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine]) pyridine-containing biaryl compound with exceptional efficacy against chronic...
β-Cells derived from stem cells hold great promise for cell replacement therapy diabetes. Here we examine the ability of nuclear transfer embryonic (NT-ESs) a patient with type 1 diabetes to differentiate into β-cells and provide source autologous islets replacement. NT-ESs in vitro an average efficiency 55% C-peptide–positive cells, expressing markers mature β-cells, including MAFA NKX6.1. Upon transplantation immunodeficient mice, grafted form vascularized islet-like structures containing...
Islet transplantation is a promising therapy for T1DM. Key factors influencing islet yield have been identified with conflicting results. In this study, we analyzed 276 isolations to identify variables and, additionally, size and distribution. Pearson correlation analyses demonstrated that BMI had positive pancreas size, actual count (AIC), equivalent (IEQ)/g (all p ≤ 0.009), while CIT negative AIC IEQ/g 0.003). mixed linear regression, also but only shorter digestion times (≤15 min); there...
Background and Aims A better understanding of the effects human adipocytes on breast cancer cells may lead to development new treatment strategies. We explored migration invasion both in vitro vivo. Methods To study reciprocal cells, we co-cultured mature a system devoid heterogeneous cell-cell contact. analyze factors that were secreted from affected invasive abilities detected different cytokines various co-culture media. communication vivo, chose 10 metastatic pathologic samples...
Direct‐acting antivirals (DAAs) have led to a high cure rate in treated patients with chronic hepatitis C virus (HCV) infection, but this still leaves large number of treatment failures secondary the emergence resistance‐associated variants (RAVs). To increase barrier resistance, complementary strategy is use neutralizing human monoclonal antibodies (HMAbs) prevent acute infection. However, earlier efforts selected RAVs animal and clinical studies. Therefore, we identified an HMAb that less...
Article13 January 2020Open Access Source DataTransparent process Inhibition of Sema4D/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy Jie-hong Wu Department Neurology, Union Hospital, Tongji Medical College, Huazhong University Science and Technology, Wuhan, China Search for more papers by this author Ya-nan Li An-qi Chen Can-dong Hong Chun-lin Zhang Hai-ling Wang Yi-fan Zhou Peng-Cheng Ophthalmology, Yong Aier School Wuhan Eye Central South University, Ling Mao...