A5024759532- Advanced Computational Techniques and Applications
- Remote Sensing and Land Use
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Additive Manufacturing and 3D Printing Technologies
- Total Knee Arthroplasty Outcomes
- Natural Fiber Reinforced Composites
- Sepsis Diagnosis and Treatment
- biodegradable polymer synthesis and properties
- Video Surveillance and Tracking Methods
- Advanced Sensor and Energy Harvesting Materials
- Remote-Sensing Image Classification
- Service-Oriented Architecture and Web Services
- Aortic Disease and Treatment Approaches
- Advanced Measurement and Detection Methods
- Cardiovascular Function and Risk Factors
- Advanced Image Fusion Techniques
- Polymer crystallization and properties
- Parallel Computing and Optimization Techniques
- Statistical Methods and Inference
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanocomposite Films for Food Packaging
- Knee injuries and reconstruction techniques
- Endoplasmic Reticulum Stress and Disease
- Graphene and Nanomaterials Applications
Liaoning Technical University
2016-2025
Donghua University
2014-2025
Anhui Medical University
2020-2025
Second Hospital of Anhui Medical University
2020-2025
Shanghai Sixth People's Hospital
2015-2025
Shanghai Jiao Tong University
2015-2025
Southern Medical University Shenzhen Hospital
2025
Anhui University
2024
Huazhong University of Science and Technology
2014-2024
Tongji Hospital
2014-2024
Bioprinting is an emerging technique for the fabrication of 3D cell-laden constructs. However, progress generating a complex physiological microenvironment has been hampered by lack advanced cell-responsive bioinks that enable bioprinting with high structural fidelity, particularly in case extrusion-based bioprinting. Herein, this paper reports novel strategy to directly bioprint gelatin methacryloyl (GelMA) constructs using GelMA physical gels (GPGs) achieved through simple cooling process....
The development of a multimaterial extrusion bioprinting platform is reported. This capable depositing multiple coded bioinks in continuous manner with fast and smooth switching among different reservoirs for rapid fabrication complex constructs, through digitally controlled from single printhead consisting bundled capillaries synergized programmed movement the motorized stage.
Bioinks with shear-thinning/rapid solidification properties and strong mechanics are usually needed for the bioprinting of three-dimensional (3D) cell-laden constructs. As such, it remains challenging to generate soft constructs from bioinks at low concentrations that favorable cellular activities. Herein, we report a strategy fabricate tunable 3D microenvironments achieved by gelatin methacryloyl (GelMA)/alginate core/sheath microfibers, where alginate sheath serves as template support...
Abstract Hydrogels with adhesive properties have potential for numerous biomedical applications. Here, the design of a novel, intrinsically hydrogel and its use in developing internal therapeutic bandages is reported. The involves incorporation “triple hydrogen bonding clusters” (THBCs) as side groups into matrix. THBC through unique “load sharing” effect an increase bond density results strong adhesions to range surfaces, including glass, plastic, wood, poly(tetrafluoroethylene) (PTFE),...
Transplantation of stem cell-derived β (SC-β) cells represents a promising therapy for type 1 diabetes (T1D). However, the delivery, maintenance, and retrieval these remain challenge. Here, we report design safe functional device composed highly porous, durable nanofibrous skin an immunoprotective hydrogel core. The consists electrospun medical-grade thermoplastic silicone-polycarbonate-urethane is soft but tough (~15 megapascal at rupture strain >2). Tuning nanofiber size to less than ~500...
A novel fibrous conduit consisting of well-aligned nanofibers with longitudinal nanogrooves on the fiber surface was prepared by electrospinning and subjected to an in vivo nerve regeneration study rats using a sciatic injury model. For comparison, having similar alignment structure without groove autograft were also conducted same test. The electrophysiological, walking track, gastrocnemius muscle, triple-immunofluorescence, immunohistological analyses indicated that grooved fibers...
The Trochanteric Fixation Nail System (TFN) was designed with a helical blade to improve resistance cutout. We evaluated the incidence, modes, and predictors of failure for intertrochanteric hip fractures treated this device.A retrospective review 341 TFN conducted. Fractures were classified from injury films using Arbeitsgemeinschaft für Osteosynthesefragen/Orthopedic Trauma Association (AO/OTA) classification, quality reduction hardware placement on initial postoperative films.Two hundred...
Embedded extrusion bioprinting allows for the generation of complex structures that otherwise cannot be achieved with conventional layer-by-layer deposition from bottom, by overcoming limits imposed gravitational force. By taking advantage a hydrogel bath, serving as sacrificial printing environment, it is feasible to extrude bioink in freeform until entire structure deposited and crosslinked. The bioprinted can subsequently released supporting used further applications. Combining this...
Abstract Oleaginous microalgae hold great promises for biofuel production. However, commercialization of microalgal biofuels remains impracticable due to the lack suitable industrial strains with high growth rate and lipid productivity. Engineering metabolic pathways is a potential strategy improvement production lipids also value‐added products in microalgae. Malonyl CoA‐acyl carrier protein transacylase (MCAT) has been reported be involved fatty acid biosynthesis. Here, we identified...
In article number 1805510, Yu Shrike Zhang and co-workers systematically review the history of 3D bioprinting its recent advances in instrumentation methods. The requirements for bioinks cells to achieve optimal fabrication biomimetic constructs, emerging evolutions future directions bioprinting, translational potential bioprinted tissues various categories, exemplary commercially available platforms are further discussed.
A cell encapsulation system generates oxygen from carbon dioxide for self-oxygenation.
Encapsulation of insulin-producing cells is a promising strategy for treatment type 1 diabetes. However, engineering an encapsulation device that both safe (i.e., no cell escape and breakage) functional low foreign-body response (FBR) high mass transfer) remains challenge. Here, family zwitterionic polyurethanes (ZPU) with sulfobetaine groups in the polymer backbone developed, which are fabricated into devices tunable nanoporous structures via electrospinning. The ZPU hydrophilic...
Previous studies reported that anterior knee pain (AKP) occurs with an incidence of 32% after opening-wedge high tibial osteotomy (OWHTO). However, the biomechanical effects this procedure on patellofemoral joints (PFJs) remain unclear. We aimed to quantify changes in kinematics and cartilage conditions PFJ during stair climbing before OWHTO. recruited 15 patients who underwent unilateral All performed continuous under surveillance a dual fluoroscopic imaging system determine accurate...
Quantitative knowledge on the anatomy of medial collateral ligament (MCL) is important for treatment MCL injury and release during total knee arthroplasty (TKA). The objective this study was to quantitatively determine morphology human knees. 10 cadaveric knees were dissected investigate anatomy. specimens fixed in full extension position maintained dissection morphometric measurements. outlines insertion sites superficial (sMCL) deep (dMCL) digitized using a 3D digitizing system. areas...
Abstract Keratins extracted from human hair have emerged as a promising biomaterial for various biomedical applications, partly due to their wide availability, low cost, minimal immune response, and the potential engineer autologous tissue constructs. However, fabrication of keratin‐based scaffolds typically relies on limited crosslinking mechanisms, such via physical interactions or disulfide bond formation, which are time‐consuming result in relatively poor mechanical strength stability....
This paper proposes a model-free and data-adaptive feature screening method for ultra-high dimensional datasets. The proposed is based on the projection correlation which measures dependence between two random vectors. does not require specifying regression model applies to data in presence of heavy-tailed errors multivariate response. It enjoys both sure rank consistency properties under weak assumptions. Further, two-step approach control false discovery rate (FDR) with help knockoff...
Tailoring the surface morphology of nanofibers determines its application to an excessive extent. At present, different structures have been produced such as wrinkled, grooved, porous, rough, etc. Amongst them, wrinkled attracted attention researchers due their exceptional structure and properties coarse surface, high energy, specific area, excellent mechanical properties, good piezoelectricity resulting in serving successfully various fields energy harvesting, air filtration, water gas...