A5100652599- Acupuncture Treatment Research Studies
- Sarcoma Diagnosis and Treatment
- Pain Mechanisms and Treatments
- Ophthalmology and Eye Disorders
- Alzheimer's disease research and treatments
- Botulinum Toxin and Related Neurological Disorders
- Management of metastatic bone disease
- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Bone Tumor Diagnosis and Treatments
- Autophagy in Disease and Therapy
- Neurological Disease Mechanisms and Treatments
- Sirtuins and Resveratrol in Medicine
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Glaucoma and retinal disorders
- Cerebrovascular and Carotid Artery Diseases
- Lung Cancer Treatments and Mutations
- Ovarian cancer diagnosis and treatment
- Healthcare and Venom Research
- Retinal Imaging and Analysis
- Cancer-related molecular mechanisms research
- Air Quality and Health Impacts
- Cardiovascular Health and Disease Prevention
Wuhan University of Science and Technology
2023-2025
Peking University
2014-2025
Guangdong Academy of Medical Sciences
2025
Southern Medical University
2013-2025
Guangdong Provincial People's Hospital
2025
Shanghai Chest Hospital
2024-2025
Shanghai Jiao Tong University
2013-2025
Shanghai Veterinary Research Institute
2024-2025
Chinese Academy of Agricultural Sciences
2024-2025
Zhengzhou University
2019-2024
BackgroundStroke is a leading cause of death and disability worldwide. Despite considerable improvements in diagnosis treatment, little known about the short-term long-term prognosis after first stroke low-income middle-income countries, including China. We aimed to assess risk recurrent mortality for each major pathological types.MethodsThis population-based cohort study included adults aged 35–74 years without who were recruited China Kadoorie Biobank (CKB). A baseline survey was conducted...
Emerging evidence suggests a potential role of neutrophil extracellular traps (NETs) in linking sterile inflammation and thrombosis. We hypothesized that NETs would be induced during myocardial ischemia-reperfusion (I/R), NET-mediated microthrombosis may contribute to "no-reflow". Male Wistar rats were randomly divided into I/R control, DNase (DNase I, 20 μg/rat), recombinant tissue-type plasminogen activator (rt-PA, 420 + rt-PA, sham control groups after 45-min ischemia. In situ NET...
Aims The aims of this retrospective study were to report the feasibility using 3D-printing technology for patients with a pelvic tumour who underwent reconstruction. Patients and Methods A total 35 resection reconstruction 3D-printed endoprostheses between September 2013 December 2015. According Enneking’s classification bone defects, there three Type I lesions, 12 II+III five I+II two I+II+III ten type I+II+IV lesions I+II+III+IV lesions. an iliac prosthesis, standard hemipelvic prosthesis...
Epidemiological studies reported associations between ozone (O3) exposure and cardiovascular diseases, yet the biological mechanisms remain underexplored. Hypoxia is a shared pathogenesis of O3-associated diseases; therefore, we hypothesized that O3 may induce changes in hypoxia-related markers, leading to adverse effects. This study aimed investigate short-term with hypoxic biomarkers arterial stiffness. We conducted panel involving 210 young healthy residents 2 cities at different...
Encapsulation of insulin-producing cells is a promising strategy for treatment type 1 diabetes. However, engineering an encapsulation device that both safe (i.e., no cell escape and breakage) functional low foreign-body response (FBR) high mass transfer) remains challenge. Here, family zwitterionic polyurethanes (ZPU) with sulfobetaine groups in the polymer backbone developed, which are fabricated into devices tunable nanoporous structures via electrospinning. The ZPU hydrophilic...
A diameter of 50 or 55 mm is the primary clinical criterion for assessing abdominal aortic aneurysm (AAA) rupture risk. However, although larger diameters may induce higher risk, not all AAAs exceeding intervention threshold will rupture, highlighting need indicators besides to help prediction and treatment AAA ≥ mm. The study aims combine computation, experiment, statistics establish models explore optimal predictors with different by anatomical hemodynamic characteristics. Through...
Context: The development of thyroid-associated ophthalmopathy (TAO) is associated with self-immune dysfunction. Recent findings in TAO and Graves' disease indicate that IL-17A may also be involved the autoimmunity TAO. Objective: We sought to investigate pathogenic function IL-17A-producing T cells Design/Setting/Participants: Blood samples orbital fibroblasts (OFs) were collected from patients healthy subjects. Main Outcome Measures: Flow cytometry, real-time PCR, cytokine-specific ELISA,...
Abstract Context T helper (Th)17 cells are correlated with many human autoimmune disorders, including Graves disease, and may play key roles in the pathogenesis of orbitopathy (GO). Objective To study phenotype Th17 patients GO healthy subjects, investigate fibrosis adipogenesis orbital fibroblasts (OFs) modulated by interleukin (IL)-17A, determine interaction between OFs. Design/Setting/Participants Blood samples tissues from controls were collected. Main Outcome Measures We conducted...
To investigate whether transcriptional factor EB (TFEB) participates in amyloid-β(1-42) (Aβ(1-42))-induced pathogenesis of Alzheimer's disease (AD) and its underlying mechanisms. Three-month-old 8-month-old transgenic APP/PS1 AD mice age-matched wild were used this study. We found that the animals presented significantly higher deposition Aβ(1-42) expression TFEB targeted proteins, such as LAMP-1 cathepsin D, autophagy-associated LC3-II p62 brain tissues than others. In an vitro study,...
Voltage-gated potassium channels (Kv) are important regulators of neuronal excitability for its role regulating resting membrane potential and repolarization. Recent studies show that Kv participate in neuropathic pain, but the detailed underlying mechanisms far from being clear. In this study, we used siRNA, miR-137 agomir, antagomir to regulate expression Kv1.2 spinal cord dorsal root ganglia (DRG) naïve chronic constriction injury (CCI) rats. currents neuron DRG neurons were examined by...
BACKGROUND: Greenness, referring to a measurement of the density vegetated land (e.g., gardens, parks, grasslands), has been linked with many human health outcomes.However, evidence on greenness exposure and microbiota remains limited, inconclusive, drawn from specific regions, based only modest sample size.OBJECTIVES: We aimed study association between microbial diversity composition in large across 34 countries regions.METHODS: explored associations residential alpha-diversity,...
Acrylamide (AA) is a toxic food contaminant that has been reported to cause glucose metabolism disorders (GMD) at high doses. However, it unclear whether chronic low-dose AA can induce GMD and probiotics alleviate AA-induced GMD. Here, C57BL/6N mice were orally administered with 5 mg per kg bw for 10 weeks, followed by another 3 weeks of glucagon-like peptide-1 (GLP-1) analogue (dulaglutide) treatment. Chronic exposure increased the blood level decreased serum insulin GLP-1 levels, whereas...
Abstract Osteosarcoma (OS), the most common primary cancer of bone, exhibits a high propensity for local invasion and distant metastasis. This study sought to elucidate role S phase kinase-associated protein (Skp2) in osteosarcoma metastasis explore flavokawain A (FKA), natural chalcone from kava extract, as potential Skp2 targeting agent preventing progression. was found be overexpressed multiple cell lines, including 5 standard 8 patient-derived lines. Patients whose tumors expressed...
X-linked agammaglobulinemia (XLA) is a humoral primary immunodeficiency. XLA patients typically present with very low numbers of peripheral B cells and profound deficiency all immunoglobulin isotypes. Most carry mutations in Bruton tyrosine kinase (BTK) gene. The genetic background clinical features 174 Chinese were investigated. relationship between specific BTK gene severity manifestations was also examined. Mutations graded from mild to severe based on structural functional prediction...
The main purpose of this study was to investigate the effects HHP pressure on structure and physicochemical properties millet gliadin. its properties, structure, conformation were systematically studied by ultraviolet second derivative spectroscopy, fluorescence Fourier transform infrared particle size analysis. treatment changed spatial gliadin increased hydrophilicity gliadin, but it did not alter distribution subunits. surface charge protein aggregation degree protein, leading increase in...
The role of plan, do, check, act (PDCA) cycle quality management in reducing nosocomial infections endoscopy rooms remains unclear; we aimed to evaluate the effects PDCA control rooms.This present study was a before and after design. patients treated our room from 1 January 2019 31 December were included group, which managed according current department practice. 2020 including formulation cleaning disinfection process, establishment an infection team improvement inspection standards....