A5101529799- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Biofuel production and bioconversion
- Bioenergy crop production and management
- Genetic Associations and Epidemiology
- Genetics and Plant Breeding
- Evolution and Genetic Dynamics
- Agronomic Practices and Intercropping Systems
- Soil Carbon and Nitrogen Dynamics
- Genetic diversity and population structure
- Genetic Syndromes and Imprinting
- HIV Research and Treatment
- Forest Biomass Utilization and Management
- Advanced Fiber Laser Technologies
- Photorefractive and Nonlinear Optics
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Plant Taxonomy and Phylogenetics
- Metabolomics and Mass Spectrometry Studies
- Solid State Laser Technologies
- Morphological variations and asymmetry
- Cancer Mechanisms and Therapy
- Seed and Plant Biochemistry
- Intracerebral and Subarachnoid Hemorrhage Research
- Computational Drug Discovery Methods
Sahlgrenska University Hospital
2025
University of Gothenburg
2025
Loyola University Chicago
2025
Hunan Agricultural University
2022-2024
École Polytechnique
2021-2022
Institut Charles Viollette
2021-2022
Université de Lille
2022
Université de Picardie Jules Verne
2022
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2022
Stony Brook University
2013-2016
BackgroundStroke is a leading cause of death and disability worldwide. Despite considerable improvements in diagnosis treatment, little known about the short-term long-term prognosis after first stroke low-income middle-income countries, including China. We aimed to assess risk recurrent mortality for each major pathological types.MethodsThis population-based cohort study included adults aged 35–74 years without who were recruited China Kadoorie Biobank (CKB). A baseline survey was conducted...
There is a gap in our understanding of mechanisms promoting hepatocellular carcinoma (HCC), and this limits ability to provide targeted therapy interventions for HCC. In HCC samples, NAD-dependent deacetylase sirtuin 2 (SIRT2) levels are increased associated with significantly worse prognosis, but the role SIRT2 hepatocarcinogenesis remains controversial. To assess hepatocarcinogenesis, we used hepatocyte-specific knockout two plasmid overexpression models: MET/CAT AKT/Nras. RNA-sequencing...
In this article, we present a statistical model for mapping quantitative trait loci (QTL) that determine growth trajectories of two correlated traits during ontogenetic development. This is derived within the maximum likelihood context, incorporated by mathematical aspects processes to mean vector and structured antedependence (SAD) models approximate time-dependent covariance matrices longitudinal traits. It provides framework testing relative importance mechanisms, pleiotropy linkage, in...
BackgroundPrevious observational studies established a positive relationship between snoring and stroke. We aimed to investigate the causal effect of on stroke.MethodsBased 82,339 unrelated individuals with qualified genotyping data Asian descent from China Kadoorie Biobank (CKB), we conducted Mendelian randomization (MR) analysis Genetic variants identified in genome-wide association (GWAS) CKB UK (UKB) were selected for constructing genetic risk scores (GRS). A two-stage method was applied...
Analysis of population structure and organization with DNA-based markers can provide important information regarding the history evolution a species. Linkage disequilibrium (LD) analysis based on allelic associations between different loci is emerging as viable tool to unravel genetic basis differentiation. In this article, we derive EM algorithm obtain maximum-likelihood estimates linkage disequilibria dominant markers, study patterns diversity for diploid The was expanded estimate test...
Abstract Growth characteristics have a complex inheritance pattern, and the gene-environment interaction makes predicting tree responses to environmental change difficult. The primary goals of this study are evaluate variation in growth traits different white poplar clones measure inter-site ecological sensitivities. In experiment, total 30 were planted measured over 5 years for height (H) diameter at breast (DBH) four sites North China. ANOVA results showed that there significant...
Genetic interactions or epistasis may play an important role in the genetic etiology of drug response. With availability large-scale, high-density single nucleotide polymorphism markers, a great challenge is how to associate haplotype structures and complex response through its underlying pharmacodynamic mechanisms.We have derived general statistical model for detecting interactive network DNA sequence variants that encode processes based on map constructed by polymorphisms. The was...
To better utilize limited resources for their survival and reproduction, all organisms undergo developmental changes in both body size shape during ontogeny. The genetic analysis of change with increasing age, i.e., growth, has received considerable attention quantitative studies, but the architecture ontogenetic its associated allometry have been poorly understood partly due to lack analytical tools. In this article, we attempt construct a multivariate statistical framework studying...
HIV infection decreases thymic output and induces chronic T-cell activation.To examine the reconstitution of naive activated T cells.Extended immune phenotyping CD4(+) CD8(+) subsets was combined with receptor rearrangement excision circle (TREC) levels measures repertoire perturbations in subpopulation to define global effect HIV-1 on dynamics. Evaluations before after therapy were performed HIV-infected children compared those healthy individuals.Ten adolescents a broad range pretherapy...
The high growth (hg) mutation increases body size in mice by 30-50%. Given the complexity of genetic regulation animal growth, it is likely that effect this major locus mediated other quantitative trait loci (QTL) with smaller effects within a web gene interactions. In article, we extend our functional mapping model to characterize modifier QTL interact hg during ontogenetic growth. Our derived maximum-likelihood context, incorporated mathematical aspects laws and implemented EM algorithm....
Genomic imprinting is a phenomenon in which the same allele expressed differently, depending on its parental origin. Such phenomenon, also called parent-of-origin effect, has been recognized to play pivotal role embryological development and pathogenesis many species. Here we propose statistical design for detecting imprinted loci that control quantitative traits based random set of three-generation families from natural population humans. This provides pathway characterizing effects genes...
Viruses can be considered 'parasites' because they cannot survive outside of a host. The progression rate to AIDS caused by human immunodeficiency virus type-1 (HIV-1) is therefore consequence HIV-host cell interactions. In this article, we present an innovative statistical model for detecting the effects genetic interactions on HIV-1 dynamics triggered different quantitative trait loci (QTL) from HIV and genomes. Our integrates principles functional mapping longitudinal traits linkage...
Summary A linkage–linkage disequilibrium map that describes the pattern and extent of linkage dis-equilibrium (LD) decay with genomic distance has now emerged as a viable tool to unravel genetic structure population differentiation fine-map genes for complex traits. The prerequisite constructing such is simultaneous estimation LD between different loci. Here, we develop computational algorithm simultaneously estimating recombination fraction in natural outcrossing multilocus marker data,...
Abstract Perennial energy crops (PECs) such as Miscanthus spp. and switchgrass ( Panicum virgatum L.) may have particular influence on microbial communities their functions in soil organic carbon (C) utilization mineralization (C m ). In this study, long‐term effects of PECs C hydrolase activities were examined bulk rhizosphere soils grown a red South China. Long‐term cultivation (10 years) led to increases (SOC) the absolute soils. Total was correlated with dissolved nitrogen (N) The...
The biological and statistical advantages of functional mapping result from joint modeling the mean-covariance structures for developmental trajectories a complex trait measured at series time points. While an increased number points can better describe dynamic pattern development, significant difficulties in performing arise prohibitive computational times required as well structure high-dimensional covariance matrix. In this article, we develop model quantitative loci (QTL) that govern...
Whether there are different genes involved in response to environmental signals and how these interact determine the final expression of trait fundamental importance agricultural biological research. We present a statistical framework for mapping environment-induced (or quantitative loci, QTLs) major effects on that respond changing environments. This is constructed with maximum-likelihood-based mixture model, which mean covariance structure responses modelled. The means continuous states,...
Background The ultimate goal of genetic mapping quantitative trait loci (QTL) is the positional cloning genes involved in any agriculturally or medically important phenotype. However, only a small portion (≤ 1%) QTL detected have been characterized at molecular level, despite report hundreds thousands for different traits and populations. Methods/Results We develop statistical model detecting characterizing nucleotide structure organization haplotypes that underlie responsible an F2...
Abstract Determining the effect of perennial energy crop (PEC) cultivation on soil organic carbon (SOC) in marginal land is vital for neutrality and bioeconomy development. However, a comprehensive systematic evaluation response SOC content to different PECs its underlying drivers still lacking. We used data collected from infertile red topsoil (0–20 cm) after 10 years with Miscanthus (MS), Panicum virgatum (SG), Saccharum arundinaceum (SA) explore changes stock induced by PEC. The roles...