A5055087045- Genetic Associations and Epidemiology
- Nutritional Studies and Diet
- Diet and metabolism studies
- Birth, Development, and Health
- Gut microbiota and health
- Amyotrophic Lateral Sclerosis Research
- Tryptophan and brain disorders
- Sleep and related disorders
- Nutrition, Genetics, and Disease
- Obesity, Physical Activity, Diet
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Risk Factors
- Epigenetics and DNA Methylation
- Nutrition and Health in Aging
- Dietary Effects on Health
- Bioinformatics and Genomic Networks
- Health disparities and outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related molecular mechanisms research
- Sodium Intake and Health
- Gestational Diabetes Research and Management
- Frailty in Older Adults
Peking University
2020-2025
Beijing Academy of Artificial Intelligence
2021-2024
King University
2021-2023
Renmin University of China
2022
Peking University Third Hospital
2021
Abstract Background Growing evidence has shown that alterations in the gut microbiota composition were associated with a variety of neuropsychiatric conditions. However, whether such associations reflect causality remains unknown. We aimed to reveal causal relationships among microbiota, metabolites, and disorders including Alzheimer’s disease (AD), major depressive disorder (MDD), schizophrenia (SCZ). Methods A two-sample bi-directional Mendelian randomization analysis was performed by...
Abstract The connection between triglyceride-rich lipoproteins and cardiometabolic multimorbidity, characterized by the concurrence of at least two type 2 diabetes, ischemic heart disease, stroke, has not been definitively established. We aim to examine prospective associations serum remnant cholesterol, triglycerides, risks progression from first disease multimorbidity via multistate modeling in UK Biobank. also evaluate causality these Mendelian randomization using 13 biologically relevant...
Abstract Background Evidence is limited regarding the association of healthy lifestyle including sleep pattern with risk complicated type 2 diabetes mellitus (T2DM) among patients hypertension. We aimed to investigate associations an overall a subsequent development T2DM participants hypertension compared normotension, and estimate how much that could be prevented. Methods This study examined six factors cases (227,966) normotension (203,005) their interaction in UK Biobank. Low-risk were...
Abstract Background: Thyroid dysfunction is associated with cardiovascular diseases. However, the role of thyroid function in lipid metabolism remains partly unknown. The present study aimed to investigate causal association between and serum via a genetic analysis termed Mendelian randomization (MR). Methods: MR approach uses variant as instrumental variable epidemiological studies mimic randomized controlled trial. A two-sample was performed assess association, using summary statistics...
Dyslipidemia has been reported to contribute the psoriasis pathogenesis. Thus, evinacumab, a novel lipid-lowering drug targeting angiopoietin-like 3, may have therapeutic potential treat and/or manage psoriasis. Summary statistics were obtained from genome-wide association studies addressing (FinnGen Consortium; n=216,752) and serum lipid concentrations (United Kingdom Biobank; n=403,943-440,546). Two-sample Mendelian randomization analyses conducted evaluate associations of genetically...
The role that sleep patterns play in sepsis risk remains poorly understood. objective was to evaluate the association between various behaviours and incidence of sepsis. In this prospective cohort study, we analysed data from UK Biobank (UKB). A total 409,570 participants who were free at baseline included. We used a composite score considered following five behaviours: chronotype, duration, insomnia, snoring, daytime sleepiness. Cox proportional hazards regression analysis estimate...
Polygenic risk score (PRS) has been shown to be predictive of disease such as type 2 diabetes (T2D). However, the existing studies on genetic prediction for T2D only had limited power. To further improve capability PRS model in identifying individuals at high risk, we proposed a new three-step filtering procedure, which aimed include truly single-nucleotide polymorphisms (SNPs) and avoid unpredictive ones into model. First, filtered SNPs according marginal association p -values ( ≤ 5× 10 −2...
Abstract We aimed to investigate the causality between potentially modifiable risk factors and of intracranial aneurysm. Genetic instruments for 51 aneurysm data were obtained from recently published genome-wide association studies. applied two-sample Mendelian randomization methods their causal relationships. Genetically predicted cigarettes per day, smoking initiation, systolic blood pressure, hypertension body fat percentage significantly associated with an increased [odds ratios (OR)...
Growing evidence suggests a mutual interaction between gut microbiome alterations and ALS pathogenesis. However, previous studies were susceptible to potential confounding factors reverse causation bias, likely leading inconsistent biased results.To decipher the potentially relationship microbiota ALS, we used bidirectional two-sample MR approach examine associations ALS.Using inverse variance-weighted method, OTU10032 unclassified Enterobacteriaceae species-level OTU Acidaminococcaceae...
Background The evidence is equivocal on the association between meat consumption and ischemic heart disease (IHD) risk. To what extent variation of individuals' metabolic responses to same diet may account for this not fully understood. We aim identify metabolomic signatures characterizing unprocessed red processed whether such are associated with IHD Methods Results conducted a cohort study 92 246 individuals (mean age, 56.1 years; 55.1% women) using UK Biobank. During median follow-up 8.74...
Abstract Background Short‐term clinical trials have shown the effectiveness of low‐carbohydrate diets (LCDs) and low‐fat (LFDs) for weight loss cardiovascular benefits. We aimed to study long‐term associations among LCDs, LFDs, mortality middle‐aged older people. Methods This included 371,159 eligible participants aged 50–71 years. Overall, healthy unhealthy LCD LFD scores, as indicators adherence each dietary pattern, were calculated based on energy intake carbohydrates, fat, protein their...
Researchers have identified an association between lifestyle factors and colorectal cancer (CRC) risk. This study examined the relationship sleep patterns CRC events. 392,252 individuals were sampled from UK Biobank. Chronotype, duration, insomnia, snoring, excessive daytime sleepiness combined to measure a healthy score. A number of defined, along with for scores. Using Cox proportional hazards regression, computed hazard ratios (HRs) used examine associations patterns, lifestyles,...
Several observational studies have indicated an association between high serum levels of branched-chain amino acids (BCAAs) and increased risk cardiovascular disease (CVD). To assess whether theses associations reflect causality, we carried out two-sample Mendelian randomization (MR). Single-nucleotide polymorphisms (SNPs) associated with BCAA were evaluated in 10 studies, including 24,925 participants. The SNPs coronary artery (CAD) assessed using summary estimates from the...
A healthy sleep pattern has been related to a lower risk of type 2 diabetes mellitus (T2DM).We aimed identify the metabolomic signature for and assess its potential causality with T2DM.This study included 78 659 participants complete phenotypic data (sleep information measurements) from UK Biobank study. Elastic net regularized regression was applied calculate reflecting overall patterns. We also performed genome-wide association analysis one-sample mendelian randomization (MR) T2DM...
Abstract Observational studies have suggested that the use of antihypertensive drugs was associated with risk frailty; however, these findings may be biased by confounding and reverse causality. This study aimed to explore effect genetically predicted lifelong lowering blood pressure (BP) through different medications on frailty. One‐sample Mendelian randomization (MR) summary data‐based MR (SMR) were applied. We utilized two kinds genetic instruments proxy medications, including variants...
Abstract Background Accumulating evidences have suggested that high body fat percentage (BF%) often occurs in parallel with cardiovascular diseases (CVDs), implying a common etiology between them. However, the shared genetic underlying BF% and CVDs remains unclear. Methods Using large-scale genome-wide association study (GWAS) data, we investigated genetics ( N = 100,716) 10 CVD-related traits n 6968-977,323) linkage disequilibrium score regression, multi-trait analysis of GWAS,...
Accumulating evidence has shown that poor oral hygiene is associated with increased risk of cardiometabolic diseases in Western populations. However, its relevance about the relationships Chinese adults remains unclear. The China Kadoorie Biobank enrolled 512 715 aged 30-79 years during 2004-2008. Cox regression was used to estimate adjusted hazard ratios (HRs) for each disease measures hygiene. Overall 9.3% participants reported rarely or never brushing teeth at baseline. Participants who...
The objective of this study is to investigate the roles cardiometabolic factors (including blood pressure, lipids, thyroid function, body mass, and insulin sensitivity) in mediating causal effect type 2 diabetes (T2DM) on cardiovascular disease (CVD) outcomes.Two-step, two-sample multivariable Mendelian randomization (MVMR) study.International genome-wide association (GWAS) consortia data.Type diabetes, pressure: systolic pressure (SBP), diastolic (DBP); lipids: low-density lipoprotein...