A5052472773- Statistical Methods and Inference
- Genetic Associations and Epidemiology
- Sparse and Compressive Sensing Techniques
- Nutritional Studies and Diet
- Statistical Methods and Bayesian Inference
- Bayesian Modeling and Causal Inference
- Bayesian Methods and Mixture Models
- Advanced Causal Inference Techniques
- Text and Document Classification Technologies
- Dementia and Cognitive Impairment Research
- Urban Transport and Accessibility
- Obesity, Physical Activity, Diet
- Face and Expression Recognition
- COVID-19 Pandemic Impacts
- Air Quality and Health Impacts
- Health Systems, Economic Evaluations, Quality of Life
- Neurological Disease Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- COVID-19 epidemiological studies
- Health disparities and outcomes
- Coffee research and impacts
- Markov Chains and Monte Carlo Methods
- Lipoproteins and Cardiovascular Health
- Ophthalmology and Visual Impairment Studies
- Medical Imaging Techniques and Applications
Peking University
2016-2025
Chongqing Emergency Medical Center
2024
Chongqing University
2024
King University
2008-2023
Beijing University of Posts and Telecommunications
2023
Shandong University
2020
University of Macau
2019-2020
Zhuhai Institute of Advanced Technology
2019
Wuhan University
2019
University of California, Berkeley
2010-2014
We examined the causal direction between gut microbiota-dependent metabolite trimethylamine N-oxide (TMAO) or its predecessors and cardiometabolic diseases, such as risk of type 2 diabetes mellitus (T2DM), coronary artery disease (CAD), myocardial infarction (MI), stroke, atrial fibrillation (AF), chronic kidney (CKD). used genetic variants instruments to test associations. Genetically predicted higher TMAO carnitine were not associated with odds T2DM, AF, CAD, MI, CKD after Bonferroni...
Abstract The connection between triglyceride-rich lipoproteins and cardiometabolic multimorbidity, characterized by the concurrence of at least two type 2 diabetes, ischemic heart disease, stroke, has not been definitively established. We aim to examine prospective associations serum remnant cholesterol, triglycerides, risks progression from first disease multimorbidity via multistate modeling in UK Biobank. also evaluate causality these Mendelian randomization using 13 biologically relevant...
Abstract Background Major depressive disorder (MDD) is clinically documented to co-occur with multiple gastrointestinal disorders (GID), but the potential causal relationship between them remains unclear. We aimed evaluate of MDD 4 GID [gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), peptic ulcer (PUD), and non-alcoholic fatty liver (NAFLD)] using a two-sample Mendelian randomization (MR) design. Methods obtained genome-wide association data for from meta-analysis ( N...
Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been recognized as a novel lipid‐lowing target. Recent clinical studies suggested the value of inhibiting PCSK9 in decreasing vulnerability coronary plaques. However, evidence PCSK9‐regulated evolution unstable carotid plaques is unclear, which limited use inhibitor This study aimed to determine effect and molecular mechanisms on plaques, provide potential therapeutic targets for stabilizing Methods The expression...
Background The purpose of this study is to assess the burden thyroid cancer over course 30 years in 204 countries and territories. Methods Data from Global Burden Disease (GBD) 2019 database was analyzed extract information on prevalence, deaths, DALYs(disability-adjusted life-years), YLL(years life los), YLD(years lived with disability), their corresponding age-standardized rates at global, regional, national levels. primary focus examine trends 1990 2019, specifically looking Estimated...
Sign consistency of the Lasso requires stringent irrepresentable condition. This paper examines whether preconditioning can circumvent this Let $\mathbf{X}\in\mathbb{R}^{n\times p}$ and $Y\in\mathbb{R}^{n}$ satisfy standard linear regression equation. Instead computing with $(\mathbf{X},Y)$, first left multiplies by $F\in\mathbb{R}^{n\times n}$ then computes $(F\mathbf{X},FY)$. While others have proposed for other purposes, we provide results that show $F\mathbf{X}$ condition even when...
Low-dose CT plays a significant role in reducing radiation risks to patients. The main challenge is achieve better image quality while lowering the imaging dose. In this work, we propose hybrid deep learning approach that combines sinogram interpolation with denoising, referred as SIPID. Through alternatively training network and denoising network, proposed SIPID can more accurate reconstructions, compared pure denoising. We empirically achieved > 2dB improvement on PSNR based Residual U-net...
Background The evidence is equivocal on the association between meat consumption and ischemic heart disease (IHD) risk. To what extent variation of individuals' metabolic responses to same diet may account for this not fully understood. We aim identify metabolomic signatures characterizing unprocessed red processed whether such are associated with IHD Methods Results conducted a cohort study 92 246 individuals (mean age, 56.1 years; 55.1% women) using UK Biobank. During median follow-up 8.74...
Summary A surrogate end point is often used to evaluate the effects of treatments or exposures on true in medical researches. Various criteria for statistical surrogate, principal and strong have been proposed. We first illustrate that, with a that defined by these criteria, it possible treatment has positive effect which turn point, but negative point. define such phenomenon as paradox. The paradox also means sign unpredictable signs both Then we propose two notions consistent strictly...
Background Ambient fine particulate matter with aerodynamic diameter less than 2.5 µm (PM ) has been associated deteriorated respiratory health, but evidence on particles in smaller sizes and childhood health limited. Methods We collected time-series data daily emergency room visits (ERVs) among children under 14 years old Beijing, China, during 2015–2017. Concurrently, size-fractioned number concentrations of size ranges 5–560 nm (PNC mass PM , black carbon (BC) nitrogen dioxide (NO 2 were...
Background Finding effective and safe therapeutic drugs for atrial fibrillation (AF) is an important concern clinicians. Proteome-wide Mendelian randomization analysis provides new ideas finding potential drug targets. Methods Results Using a proteome-wide approach, we assessed the genetic predictive causality between thousands of proteins AF risk found that genetically predicted plasma levels phosphomevalonate kinase, tumor necrosis factor ligand superfamily member 12, sulfhydryl oxidase 2,...
A healthy sleep pattern has been related to a lower risk of type 2 diabetes mellitus (T2DM).We aimed identify the metabolomic signature for and assess its potential causality with T2DM.This study included 78 659 participants complete phenotypic data (sleep information measurements) from UK Biobank study. Elastic net regularized regression was applied calculate reflecting overall patterns. We also performed genome-wide association analysis one-sample mendelian randomization (MR) T2DM...
Abstract Observational studies have suggested that the use of antihypertensive drugs was associated with risk frailty; however, these findings may be biased by confounding and reverse causality. This study aimed to explore effect genetically predicted lifelong lowering blood pressure (BP) through different medications on frailty. One‐sample Mendelian randomization (MR) summary data‐based MR (SMR) were applied. We utilized two kinds genetic instruments proxy medications, including variants...
The oldest-old (aged 80 or older) are the most rapidly growing age group, and they more likely to suffer from cognitive impairment, leading severe medical economic burdens. influence of intergenerational relationships on cognition among Chinese adults is not clear. We aim examine association with impairment aged older.This was a prospective cohort study, data were obtained Longitudinal Healthy Longevity Survey, 14,180 participants older at least one follow-up survey 1998 2018. Cognitive...
Graphical models are popular statistical tools which used to represent dependent or causal complex systems. Statistically equivalent directed graphical said belong a Markov class. It is of great interest describe and understand the space such classes. However, with currently known algorithms, sampling over classes only feasible for graphs fewer than approximately 20 vertices. In this paper, we design reversible irreducible chains on by proposing perfect set operators that determine...
Late-onset Alzheimer's disease (AD) is associated with sleep-related phenotypes (SRPs). The fact that whether they share a common genetic etiology remains largely unknown. We explored the shared genetics and causality between AD SRPs by using high-definition likelihood (HDL), cross-phenotype association study (CPASSOC), transcriptome-wide (TWAS), bidirectional Mendelian randomization (MR) in summary-level data for (N = 455,258) seven (sample size ranges from 359,916 to 1,331,010). strong...