A5056924241- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Pancreatic and Hepatic Oncology Research
- Climate variability and models
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- Luminescence Properties of Advanced Materials
- Advanced Nanomaterials in Catalysis
- Melanoma and MAPK Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Perovskite Materials and Applications
- Peptidase Inhibition and Analysis
- Plant Water Relations and Carbon Dynamics
- CAR-T cell therapy research
- Esophageal Cancer Research and Treatment
- Legal Education and Practice Innovations
- Gastrointestinal Tumor Research and Treatment
- Cancer, Lipids, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Extracellular vesicles in disease
- Brain Metastases and Treatment
Anhui Normal University
2023-2025
Microbiology Institute of Shaanxi
2021-2025
Institute of Microbiology
2021-2025
Chinese Academy of Sciences
2010-2025
Annoroad Gene Technology (China)
2021-2025
China University of Mining and Technology
2025
Hebei Medical University
2019-2024
Second Hospital of Hebei Medical University
2019-2024
Institute of Geographic Sciences and Natural Resources Research
2020-2024
Children's Hospital of Fudan University
2008-2024
Importance Uninterrupted targeted therapy until disease progression or intolerable toxic effects is currently the routine for advanced non−small cell lung cancer (NSCLC) involving driver gene variations. However, drug resistance inevitable. Objective To assess clinical feasibility of adaptive de-escalation tyrosine kinase inhibitor (TKI) treatment guided by circulating tumor DNA (ctDNA) achieving complete remission after local consolidative (LCT) in patients with NSCLC. Design, Setting, and...
The most deadly phase in cancer progression is metastatic conversion. Epithelial-to-mesenchymal transition (EMT) a key process by which cells acquire invasive and phenotypes. In order to spawn macroscopic metastases, disseminated would seem require self-renewal capability. However, the underlying mechanism defining these processes poorly understood. One possible metastasis fusion between myeloid cells. this study, we found that spontaneously-formed tumorigenic hybrids bone marrow-derived...
Abstract Lessons Learned Background We conducted a phase Ib study of radiotherapy plus programmed cell death protein 1 (PD-1) monoclonal antibody camrelizumab as first-line treatment for locally advanced esophageal squamous carcinoma (ESCC). Methods planned to enroll 20 patients with newly diagnosed ESCC. Patients received 60 Gy radiation (2.0 Gy/fraction, 5 fractions/week), (200 mg every 2 weeks) starting and continuing 32 weeks (i.e., 16 cycles). The primary endpoints were safety...
BackgroundCirculating tumor DNA (ctDNA) isolated from plasma contains genetic mutations that can be representative of those found in primary tissue DNA. These samples provide insights into tumoral heterogeneity patients with advanced gastric cancer (AGC). Although trastuzumab has been shown to effective first-line therapy for metastatic overexpression human epidermal growth factor receptor 2 (HER2), the mechanism AGC resistance is incompletely understood.MethodsIn this prospective study, we...
In this study, we investigated the effect of fucoidan polysaccharide sulfuric acid ester (FPS) from Laminaria japonica Aresch (Laminariaceae) on hyperlipidemic rats. FPS notably reduced concentration serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL-C) rats increased high-density (HDL-C) activities lipase (LPL), hepatic (HL), lecithin acyltransferase (LCAT).
Abstract One of the most encouraging developments in oncology has been success BRAF inhibitors BRAF-mutant melanoma. However, contrast to its striking efficacy melanomas, inhibitor monotherapy is ineffective colorectal cancer. Although many studies on resistance cancer have focused mechanisms underlying reactivation EGFR/RAS/RAF/MEK/ERK pathway, current study focuses identifying novel adaptive signaling mechanisms, a fresh angle inhibition. We found that treatment with (both and...
CCND1 amplification relevant to malignant biological behavior exist in solid tumors. The prevalence and utility of as a biomarker for the clinical response treatment with immune checkpoint inhibitors (ICIs) is unknown. We examined its potential efficacy ICIs therapy tumors using local database (n=6536), TCGA (n=10606) MSKCC (n=10109). Comprehensive profiling was performed determine correlation prognosis ICIs. A occurs many cancer types, correlates shorter overall survival, inferior outcomes...
The current standard of care for locally advanced gastric cancer (GC) involves neoadjuvant chemotherapy followed by radical surgery. Recently, treatment this condition has involved the exploration immunotherapy plus as a potential approach. However, efficacy remains uncertain.
About 76% of patients with lung adenocarcinoma harbor activating mutations in the receptor tyrosine kinase (RTK)/RAS/RAF pathways, leading to aberrant activation mitogen-activated protein (MAPK) pathways particularly MAPK/ERK pathway. However, many adenocarcinomas lacking these genomic also display significant MAPK pathway activation, suggesting that additional alterations remain undetected. This study has identified serine/threonine 4 (MAP4K4) as a novel positive regulator signaling...
Developing a biocompatible nanotheranostic platform integrating diagnostic and therapeutic functions is great prospect for cancer treatment. However, it still challenge to synthesize agents using an ultra-facile method. In the research reported here, ultrasmall polyethylenimine-protected silver bismuth sulfide (PEI-AgBiS2) nanodots were successfully synthesized environmentally friendly strategy (1 min only at room temperature), which could be described as "rookie method". PEI-AgBiS2 show...
Previous studies found that lung adenocarcinomas (LUAD) with EGFR-positive and ALK-positive were less responsive to immunotherapy, which may be associated a suppressive tumor immune microenvironment (TIME). Given the discordance in TIME between primary cancer brain metastasis, it is urgent explore patients EGFR/ALK-positive LUAD metastases (BMs).The transcriptome feature of formalin-fixed paraffin-embedded samples BMs paired from 70 was illustrated by RNA-sequencing. Six them available for...
Polyvinylpyrrolidone-modified CuS nanocrystals (CuS NCs) with high photothermal conversion efficiency (46%) and pH near-infrared (NIR) light-triggered degradation properties are a promising nanotheranostic platform for in situ magnetic resonance imaging (MRI)-guided synergistic photodynamic therapy. On the one hand, (102) surface of NCs has small bandgap based on density functional theory, which leads to efficiency. other S vacancy formation energy is favourable. entry into tumor cells...
Circulating tumor DNA (ctDNA) has potential as a promising biomarker for molecular residual disease (MRD) detection in lung cancer. As the next‐generation sequencing standardized panel ctDNA emerges, its clinical utility needs to be validated. We prospectively recruited 184 resectable cancer patients from four medical centers. Serial postoperative ctDNAs were analyzed by panel. A total of 427 plasma samples 177 eligible enrolled. positivity after surgery was an independent predictor...
Abstract Background Exploring predictive biomarkers and therapeutic strategies of ICBs has become an urgent need in clinical practice. Increasing evidence shown that ARID1A deficiency might play a critical role sculpting tumor environments various tumors be used as pan-cancer for immunotherapy outcomes. The current study aims to explored the immune-modulating Hepatitis B virus (HBV) related hepatocellular carcinoma (HBV-HCC) its potential immunotherapeutic implications. Methods In study, we...
Background: This study aimed to investigate glycogen metabolism in gastric cancer (GC) and develop a glycogen-based riskScore model for predicting GC prognosis. Methods: Patients' expression profiles 33 tumor types were retrieved from TCGA. Four bulk one single-cell sequencing datasets obtained GEO database. also enrolled bladder urothelial carcinoma immunotherapeutic IMvigor210 cohort. The ssGSEA method was conducted assess biosynthesis degradation level. Consensus clustering analysis...
The acidic taste of Mei fruit (Prunus mume) is a major contributor to its quality, but formation mechanism remains unclear. Here, we unraveled the networks organic acid and flavonoid metabolism in two fruit. results showed that differentially expressed genes were mainly concentrated processes carbohydrate derivative binding, carboxylic acid, metabolism. While accumulated metabolites associated with flavone flavonol biosynthesis amino carbon Moreover, identified key metabolites, such as...